Browse by author
Lookup NU author(s): Dr Sally Coulthard
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Thiopurines are the backbone of current anti-leukemia regimens and have also been effective immunosuppressive agents for the past half a century. Extensive research on their mechanism of action has been undertaken, yet many issues remain to be addressed to resolve unexplained cases of thiopurine toxicity or treatment failure. The aim of this review is to summarize current knowledge of the mechanism of thiopurine action in experimental models and put into context with clinical observations. Clear understanding of their metabolism will contribute to maximizing efficacy and minimizing toxicity by individually tailoring therapy according to the expression profile of relevant factors involved in thiopurine activation pathway. (C) 2010 Published by Elsevier Inc.
Author(s): Fotoohi AK, Coulthard SA, Albertioni F
Publication type: Article
Publication status: Published
Journal: Biochemical Pharmacology
Print publication date: 01/05/2010
ISSN (print): 0006-2952
ISSN (electronic): 1873-2968
Publisher: Elsevier Inc.
Altmetrics provided by Altmetric