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Thiopurines: Factors influencing toxicity and response

Lookup NU author(s): Dr Sally Coulthard

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Abstract

Thiopurines are the backbone of current anti-leukemia regimens and have also been effective immunosuppressive agents for the past half a century. Extensive research on their mechanism of action has been undertaken, yet many issues remain to be addressed to resolve unexplained cases of thiopurine toxicity or treatment failure. The aim of this review is to summarize current knowledge of the mechanism of thiopurine action in experimental models and put into context with clinical observations. Clear understanding of their metabolism will contribute to maximizing efficacy and minimizing toxicity by individually tailoring therapy according to the expression profile of relevant factors involved in thiopurine activation pathway. (C) 2010 Published by Elsevier Inc.

Publication metadata

Author(s): Fotoohi AK, Coulthard SA, Albertioni F

Publication type: Article

Publication status: Published

Journal: Biochemical Pharmacology

Year: 2010

Volume: 79

Issue: 9

Pages: 1211-1220

Print publication date: 01/05/2010

ISSN (print): 0006-2952

ISSN (electronic): 1873-2968

Publisher: Elsevier Inc.

URL: http://dx.doi.org/10.1016/j.bcp.2010.01.006

DOI: 10.1016/j.bcp.2010.01.006

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