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Browsing publications by Dr Sally Coulthard.

Newcastle AuthorsTitleYearFull text
Dr Chris Redfern
Dr Sally Coulthard
Increased DNA-incorporated thiopurine metabolite as a possible mechanism for leukocytopenia through cell apoptosis in inflammatory bowel disease patients with NUDT15 mutation2021
Dr Tom Chamberlain
Dr Sally Coulthard
Mohammad Alshabeeb
Professor Ann Daly
Drugā€Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles2019
Dr Sally Coulthard
Dr Chris Redfern
Metabolites of endophytic fungi from Australian native plants as potential anticancer agents2018
Dr Sally Coulthard
Sarah McGarrity
Dr Kiran Sahota
Phil Berry
Dr Chris Redfern
et al.
Three Faces of Mercaptopurine Cytotoxicity in vitro: Methylation, Nucleotide Homeostasis and Deoxythioguanosine in DNA2018
Dr Sally Coulthard
Professor Chris Day
Professor Ann Daly
Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study2017
Dr Sally Coulthard
Phil Berry
Sarah McGarrity
Dr Chris Redfern
Azathioprine with Allopurinol: Lower Deoxythioguanosine in DNA and Transcriptome Changes Indicate Mechanistic Differences to Azathioprine Alone2017
Dr Sally Coulthard
Phil Berry
Sarah McGarrity
Dr Chris Redfern
A Novel Assay for The Direct Detection of Deoxythioguanosine (DTG) in DNA from Patients On Azathioprine Using Liquid Chromatography and Tandem Mass Spectrometry (LC-MS/MS)2016
Dr Sally Coulthard
Phil Berry
Sarah McGarrity
Abdul-Haq Ansari
Dr Chris Redfern
et al.
Deoxythioguanosine (DTG) in DNA as a Pharmacological Endpoint of Thiopurine Treatment in Inflammatory Bowel Disease Patients2016
Dr Sally Coulthard
Professor Ann Daly
HLA-DRB1*16:01-DQB1*05:02 is a novel genetic risk factor for flupirtine-induced liver injury2016
Dr Sally Coulthard
Phil Berry
Sarah McGarrity
Dr Chris Redfern
Liquid chromatography-mass spectrometry for measuring deoxythioguanosine in DNA from thiopurine-treated patients2016
Dr Sally Coulthard
Phil Berry
Sarah McGarrity
Dr Chris Redfern
Liquid chromatography-mass spectrometry for measuring deoxythioguanosine in DNA from thiopurine-treated patients2016
Dr Sally Coulthard
Professor Ann Daly
Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting2016
Dr Sally Coulthard
Phil Berry
Sarah McGarrity
Dr Chris Redfern
Direct Detection of Thiopurine Metabolites in Erythrocytes and Leukocytes Using a Novel LCMS/MS Method to Interrogate Drug Response and in vivo Metabolism2014
Dr Sally Coulthard
Nomenclature for alleles of the thiopurine methyltransferase gene2013
Professor Ann Daly
Professor Gareth Veal
Dr David Jamieson
Dr Sally Coulthard
Pharmacogenomics research at Newcastle University2012
Dr Sally Coulthard
Dr Chris Redfern
Svante Vikingsson
Dr Malin Lindqvist Appell
Dr Andrew Hall
et al.
Increased Sensitivity to Thiopurines in Methylthioadenosine Phosphorylase-Deleted Cancers2011
Tomasz Zaremba
Huw Thomas
Mike Cole
Dr Sally Coulthard
Professor Ruth Plummer
et al.
Poly(ADP-ribose) polymerase-1 (PARP-1) pharmacogenetics, activity and expression analysis in cancer patients and healthy volunteers2011
Dr Sally Coulthard
Dr Chris Redfern
Dr Linda Hogarth
Increased sensitivity to thiopurines in methylthioadenosine phosphorylase-deleted cancers [abstract]2010
Dr Sally Coulthard
Thiopurines: Factors influencing toxicity and response2010
Professor Ruth Plummer
Melanie Griffin
Dr Sally Coulthard
Julieann Sludden
Professor Alan Calvert
et al.
Phase I Study of MG98, an Oligonucleotide Antisense Inhibitor of Human DNA Methyltransferase 1, Given as a 7-Day Infusion in Patients with Advanced Solid Tumors2009
Tomasz Zaremba
Professor Ruth Plummer
Dr Sally Coulthard
Mike Cole
Professor Nicola Curtin
et al.
Poly(ADP-ribose) polymerase-1 polymorphisms, expression and activity in a panel of human tumor cell lines [abstract]2009
Tomasz Zaremba
Mike Cole
Dr Sally Coulthard
Professor Ruth Plummer
Professor Nicola Curtin
et al.
Poly(ADP-ribose) polymerase-1 polymorphisms, expression and activity in selected human tumour cell lines2009
Dr Sally Coulthard
Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Munster protocols2009
Tomasz Zaremba
Mike Cole
Dr Sally Coulthard
Professor Ruth Plummer
Professor Nicola Curtin
et al.
Poly(ADP-ribose) polymerase-1 (PARP-1) genomics in relation to activity in healthy volunteers and cancer patients2008
Dr Linda Hogarth
Dr Chris Redfern
Dr Andrew Hall
Dr Holly Anderson
Marian Case
et al.
The effect of thiopurine drugs on DNA methylation in relation to TPMT expression2008
Mark Leslie
Marian Case
Dr Andrew Hall
Dr Sally Coulthard
Expression levels of asparagine synthetase in blasts from children and adults with acute lymphoblastic leukaemia2006
Dr Sally Coulthard
Dr Linda Hogarth
The thiopurines: An update2005
Dr Sally Coulthard
Dr Linda Hogarth
Old drugs-current perspectives2004
Dr Sally Coulthard
Dr Andrew Hall
Dr Linda Hogarth
The clinical impact of thiopurine methyltransferase polymorphisms on thiopurine treatment2004
Professor Gareth Veal
Dr Sally Coulthard
Professor Alan Boddy
Chemotherapy individualization2003
Dr Andrew Hall
Dr Sally Coulthard
Professor Julie Irving
Molecular diagnostics: a healthcare perspective2003
Mark Leslie
Marian Case
Dr Andrew Hall
Dr Sally Coulthard
Potential use of asparagine synthetase levels in the individualisation of L-asparaginase therapy2003
Dr Linda Hogarth
Dr Sally Coulthard
Dr Andrew Hall
Lindi Skitt
The effect of thiopurine methyltransferase on the cytotoxic action of thiopurine drugs2003
Nadia Thornton
Dr Andrew Hall
Dr Sally Coulthard
The use of real-time PCR to validate methylthioadenosine phosphorylase and p16 deletions as a new drug target in childhood acute lymphoblastic leukaemia2003
Dr Sally Coulthard
Dr Linda Hogarth
Dr Margaret Little
Elizabeth Matheson
Dr Chris Redfern
et al.
The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs2002
Dr Linda Hogarth
Dr Margaret Little
Lynne Minto
Dr Chris Redfern
Dr Andrew Hall
et al.
High thiopurine methyltransferase expression confers different levels of resistance with 6-thioguanine compared to 6-mercaptopurine.2001
Dr Linda Hogarth
Dr Margaret Little
Lynne Minto
Dr Chris Redfern
Dr Andrew Hall
et al.
In vitro evidence for differences in 6-mercaptopurine versus 6-thioguanine metabolism depending on TPMT status2001
Mark Leslie
Marian Case
Dr Andrew Hall
Dr Sally Coulthard
Measurement of aspargine synthetase mRNA levels by real-time PCR2001
Dr Sally Coulthard
Dr Andrew Hall
Recent advances in the pharmacogenomics of thiopurine methyltransferase2001
Dr Andrew Hall
Dr Peter Hamilton
Lynne Minto
Dr Sally Coulthard
The use of denaturing high-pressure liquid chromatography for the detection of mutations in thiopurine methyltransferase2001
Dr Sally Coulthard
Dr Christopher Howell
Lynne Minto
Dr Peter Middleton
Professor Graham Jackson
et al.
A comparison of molecular and enzyme-based assays for the detection of thiopurine methyltransferase mutations2000
Dr Sally Coulthard
Dr Linda Hogarth
Lynne Minto
Dr Chris Redfern
Dr Andrew Hall
et al.
High thiopurine methyltransferase expression confers different levels of resistance with 6-thioguanine compared to 6-mercaptopurine2000
Dr Sally Coulthard
Dr Christopher Howell
Jill Robson
Dr Andrew Hall
The relationship between thiopurine methyltransferase activity and genotype in blasts from patients with acute leukemia1998
Dr Sally Coulthard
Dr Anne Lennard
Abnormalities of chromosome band 8p11 in leukemia: Two clinical syndromes can be distinguished on the basis of MOZ involvement1997
Dr David Wilson
Ian Cross
Professor Judith Goodship
Dr Sally Coulthard
Dr Hugh Bain
et al.
DiGeorge syndrome with isolated aortic coarctation and isolated ventricular septal defect in three sibs with a 22q11 deletion of maternal origin1991