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Lookup NU author(s): Professor Chris Day
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Abdominal obesity represents a public health concern because its prevalence is reaching epidemic proportions worldwide, and it is associated with an increased risk of cardiovascular morbidity and mortality and other pathological conditions. A large body of evidence suggests that abdominal obesity is associated with a prothrombotic tendency, which may, at least in part, contribute to the increased risk of atherothrombosis in these individuals. This review briefly summarizes the evidence of direct and indirect effects of the accumulation of excess lipid in visceral adipose tissue on coagulation and fibrinolysis. In addition, this article critically appraises the rapidly expanding body of experimental and clinical data that support a potential direct contribution for the accumulation of excess lipid in the liver (i.e., nonalcoholic fatty liver disease, a very frequent pathological condition in subjects with abdominal obesity) in the pathogenesis of the obesity-induced disorders of coagulation and fibrinolysis.
Author(s): Targher G, Zoppini G, Moghetti P, Day CP
Publication type: Article
Publication status: Published
Journal: Seminars in Thrombosis and Hemostasis
Year: 2010
Volume: 36
Issue: 1
Pages: 41-48
Print publication date: 01/02/2010
ISSN (print): 0094-6176
ISSN (electronic): 1098-9064
Publisher: Thieme Medical Publishers
URL: http://dx.doi.org/10.1055/s-0030-1248723
DOI: 10.1055/s-0030-1248723
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