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Pathogenesis of Arteriovenous Malformations in the Absence of Endoglin

Lookup NU author(s): Dr Marwa Mahmoud, Kathleen Allinson, Dr Jason Zhai, Rachael Oakenfull, Professor Helen Arthur

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Abstract

Rationale: Arteriovenous malformations (AVMs) result in anomalous direct blood flow between arteries and veins, bypassing the normal capillary bed. Depending on size and location, AVMs may lead to severe clinical effects including systemic cyanosis (pulmonary AVMs), hemorrhagic stroke (cerebral AVMs) and high output cardiac failure (hepatic AVMs). The factors leading to AVM formation are poorly understood, but patients with the familial disease hereditary hemorrhagic telangiectasia (HHT) develop AVMs at high frequency. As most HHT patients have mutations in ENG (endoglin) or ACVRL1 (activin receptor-like kinase 1), a better understanding of the role of these genes in vascular development is likely to reveal the etiology of AVM formation. Objective: Using a mouse with a conditional mutation in the Eng gene, we investigated the sequence of abnormal cellular events occurring during development of an AVM. Methods and Results: In the absence of endoglin, subcutaneous Matrigel implants in adult mice were populated by reduced numbers of new blood vessels compared with controls, and resulted in local venous enlargement (venomegaly). To investigate abnormal vascular responses in more detail, we turned to the more readily accessible vasculature of the neonatal retina. Endoglin-deficient retinas exhibited delayed remodeling of the capillary plexus, increased proliferation of endothelial cells and localized AVMs. Muscularization of the resulting arteriovenous shunts appeared to be a secondary response to increased blood flow. Conclusions: AVMs develop when an angiogenic stimulus is combined with endoglin depletion. Moreover, AVM formation appears to result from the combination of delayed vascular remodeling and an inappropriate endothelial cell proliferation response in the absence of endoglin. (Circ Res. 2010;106:1425-1433.)


Publication metadata

Author(s): Mahmoud M, Allinson KR, Zhai ZH, Oakenfull R, Ghandi P, Adams RH, Fruttiger M, Arthur HM

Publication type: Article

Publication status: Published

Journal: Circulation Research

Year: 2010

Volume: 106

Issue: 8

Pages: 1425-1433

Print publication date: 01/04/2010

ISSN (print): 0009-7330

ISSN (electronic): 1524-4571

Publisher: Lippincott Williams & Wilkins

URL: http://dx.doi.org/10.1161/CIRCRESAHA.109.211037

DOI: 10.1161/CIRCRESAHA.109.211037


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