Publications by Professor Helen Arthur - ePrints

Browsing publications by Professor Helen Arthur.

Newcastle Authors	Title	Year
Professor Helen Arthur	ANG2 Blockade Diminishes Proangiogenic Cerebrovascular Defects Associated With Models of Hereditary Hemorrhagic Telangiectasia	2023
Professor Helen Arthur	Therapeutic targeting of vascular malformation in a zebrafish model of hereditary haemorrhagic telangiectasia	2023
Professor Helen Arthur	An update on preclinical models of hereditary haemorrhagic telangiectasia: Insights into disease mechanisms	2022
Dr Anna Walaszczyk Dr Emily Dookun Dr Rachael Redgrave Dr Pawel Palmowski Dr Simon Tual-Chalot et al.	Therapeutic potential of navitoclax in age-related cardiovascular diseases	2022
Emily Dookun Dr Joao Passos Professor Helen Arthur Professor Gavin Richardson	Therapeutic Potential of Senolytics in Cardiovascular Disease	2022
Dr Esha Singh Dr Helen Phillips Professor Helen Arthur	Dynamic changes in endoglin expression in the developing mouse heart	2021
Nina Jordan Dr Sam Tingle Victoria Shuttleworth Katie Cooke Dr Rachael Redgrave et al.	MiR-126-3p Is Dynamically Regulated in Endothelial-to-Mesenchymal Transition during Fibrosis	2021
Dr Sarah Marsh Dr Catherine Park Dr Rachael Redgrave Dr Esha Singh Lilia Draganova et al.	Rapid fall in circulating non-classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury	2021
Dr Esha Singh Dr Rachael Redgrave Dr Helen Phillips Professor Helen Arthur	Arterial endoglin does not protect against arteriovenous malformations	2020
Dr Carmen Martin-Ruiz Professor Thomas von Zglinicki Professor Gavin Richardson Lilia Draganova Dr Rachael Redgrave et al.	CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians	2020
Dr Simon Tual-Chalot Dr Rachael Redgrave Dr Esha Singh Dr Benjamin Davison Dr Catherine Park et al.	Loss of endothelial Endoglin promotes high-output heart failure through peripheral arteriovenous shunting driven by VEGF signalling	2020
Professor Helen Arthur	Oncogenes in brain arteriovenous malformations	2020
Professor Helen Arthur	Overexpression of Activin Receptor-Like Kinase 1 in Endothelial Cells Suppresses Development of Arteriovenous Malformations in Mouse Models of Hereditary Hemorrhagic Telangiectasia	2020
Dr Catherine Park Dr Suzanne Cormack Dr Stephen Boag Dr Karim Bennaceur Professor Gavin Richardson et al.	Role of CMV-serostatus and CX3CR1 on lymphocyte kinetics and left ventricular remodelling in patients with acute myocardial infarction	2020
Dr Kate Bailey Dr Guy MacGowan Dr Simon Tual-Chalot Lauren Charlotte Phillips Phillips Professor Deborah Henderson et al.	Disruption of embryonic ROCK signalling reproduces the sarcomeric phenotype of Hypertrophic Cardiomyopathy	2019
Rhys Anderson Anthony Lagnado Damien Maggiorani Dr Anna Walaszczyk Emily Dookun et al.	Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence	2019
Emily Dookun Dr Anna Walaszczyk Dr Rachael Redgrave Dr Simon Tual-Chalot Oliver Yausep et al.	Navitoclax eliminates senescence attenuating remodelling and improving outcome to cardiac ischemia-reperfusion injury	2019
Dr Anna Walaszczyk Emily Dookun Dr Rachael Redgrave Dr Simon Tual-Chalot Professor Ioakim Spyridopoulos et al.	Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction.	2019
Dr Rachael Redgrave Professor Helen Arthur	Role of soluble endoglin in BMP9 signaling	2019
Oliver Yausep Emily Dookun Dr Anna Walaszczyk Dr Rachael Redgrave Dr Simon Tual-Chalot et al.	The Effects of Senolytics on Murine Cardiac Function and Morphology Post-Ischemia Reperfusion Injury	2019
Emily Dookun Dr Anna Walaszczyk Dr Rachael Redgrave Dr Simon Tual-Chalot Oliver Yausep et al.	Accumulation of cardiomyocyte senescence following ischaemia-reperfusion injury (IRI); a potential therapeutic target?	2018
Emily Dookun Dr Anna Walaszczyk Dr Rachael Redgrave Dr Simon Tual-Chalot Oliver Yausep et al.	Cardiomyocyte Senescence accumulates following Myocardial Infarction and Ischaemia-Reperfusion Injury.	2018
Dr Simon Tual-Chalot Professor Helen Arthur	Decreased Expression of Vascular Endothelial Growth Factor Receptor 1 Contributes to the Pathogenesis of Hereditary Hemorrhagic Telangiectasia Type 2	2018
Professor Helen Arthur	Executive summary of the 12th HHT international scientific conference	2018
Dr Anna Walaszczyk Emily Dookun Dr Rachael Redgrave Dr Simon Tual-Chalot Rhys Anderson et al.	Senescence as a therapeutic target for myocardial ageing	2018
Dr Anna Walaszczyk Emily Dookun Dr Rachael Redgrave Professor Ioakim Spyridopoulos Professor Helen Arthur et al.	Senescence contributes age related cardiac dysfunction	2018
Dr Anna Walaszczyk Emily Dookun Dr Rachael Redgrave Professor Ioakim Spyridopoulos Professor Helen Arthur et al.	Senescence contributes to reduced survival and impaired cardiac function following myocardial infraction in aged mice.	2018
Eunate Gallardo Vara Dr Simon Tual-Chalot Professor Helen Arthur	Soluble endoglin regulates expression of angiogenesis-related proteins and induction of arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia	2018
Dr Rachael Redgrave Dr Simon Tual-Chalot Dr Benjamin Davison Dr Esha Singh Dr Darroch Hall et al.	Cardiosphere-Derived Cells Require Endoglin for Paracrine-Mediated Angiogenesis	2017
Professor Helen Arthur	Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling	2017
Professor Helen Arthur	Inhibiting DPP4 in a mouse model of HHT1 results in a shift towards regenerative macrophages and reduces fibrosis after myocardial infarction	2017
Professor Ioakim Spyridopoulos Professor Helen Arthur	Microvessels of the heart: Formation, regeneration and dysfunction	2017
Dr Sarah Marsh Professor Helen Arthur Professor Ioakim Spyridopoulos	The secret life of nonclassical monocytes	2017
Professor Helen Arthur	Endoglin is required in Pax3-derived cells for embryonic blood vessel formation	2016
Professor Helen Arthur	Interaction Between ALK1 Signaling and Connexin40 in the Development of Arteriovenous Malformations	2016
Dr Simon Tual-Chalot Dr Rachael Redgrave Professor Helen Arthur	Loss of Endothelial Endoglin Leads to Heart Failure	2016
Professor Helen Arthur	Mice Lacking Endoglin in Macrophages Show an Impaired Immune Response	2016
Dr Marwa Mahmoud Professor Helen Arthur	Modulation of endoglin expression in islets of langerhans by VEGF reveals a novel regulator of islet endothelial cell function	2016
Professor Helen Arthur	Persistent infiltration and pro-inflammatory differentiation of monocytes causing unresolved inflammation in brain arteriovenous malformation	2016
Professor Bob Anderson Dr Simon Tual-Chalot Dr Rachael Redgrave Rebecca Dodds Dr Andrew Owens et al.	The role of cardiomyocyte senescence and regeneration in Ageing	2016
Dr Rachael Redgrave Dr Simon Tual-Chalot Dr Benjamin Davison Liz Greally Dr Mauro Santibanez Koref et al.	Using MRI to predict future adverse cardiac remodelling in a male mouse model of myocardial infarction	2016
Dr Simon Tual-Chalot Dr Benjamin Davison Dr Rachael Redgrave Professor Helen Arthur	Endoglin is required to maintain normal cardiac function in adult life	2015
Professor Helen Arthur	Executive summary of the 11th HHT international scientific conference	2015
Dr Simon Tual-Chalot Professor Helen Arthur	Mouse models of hereditary hemorrhagic telangiectasia: recent advances and future challenges	2015
Professor Helen Arthur	Common and Distinctive Pathogenetic Features of Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia 1 and Hereditary Hemorrhagic Telangiectasia 2 Animal Models-Brief Report	2014
Professor Helen Arthur	ENDOGLIN Is Dispensable for Vasculogenesis, but Required for Vascular Endothelial Growth Factor-Induced Angiogenesis	2014
Dr Simon Tual-Chalot Dr Marwa Mahmoud Kathleen Allinson Dr Rachael Redgrave Professor Helen Arthur et al.	Endothelial Depletion of Acvrl1 in Mice Leads to Arteriovenous Malformations Associated with Reduced Endoglin Expression	2014
Dr Simon Tual-Chalot Dr Rachael Redgrave Professor Helen Arthur	Endothelial expression of endoglin and Acvrl1 are required for normal vascular patterning during developmental angiogenesis and for maintaining adult vessel integrity	2014
Sarah Thompson Dr Rachael Redgrave Emeritus Professor John Kirby Professor Helen Arthur Professor Simi Ali et al.	Modulation of wound healing post-myocardial infarction	2014
Professor Helen Arthur	Novel Brain Arteriovenous Malformation Mouse Models for Type 1 Hereditary Hemorrhagic Telangiectasia	2014
Dr Jason Zhai Ross Cordiner Professor Helen Arthur	Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination	2013
Dr Jason Zhai Professor Helen Arthur	LRG1 promotes angiogenesis by modulating endothelial TGFß signalling	2013
Dr Ingrid Ehrmann Caroline Dalgliesh Dr Marina Danilenko Moira Crosier Lynne Overman et al.	The Tissue-Specific RNA Binding Protein T-STAR Controls Regional Splicing Patterns of Neurexin Pre-mRNAs in the Brain	2013
Dr Simon Tual-Chalot Kathleen Allinson Professor Helen Arthur	Whole Mount Immunofluorescent Staining of the Neonatal Mouse Retina to Investigate Angiogenesis In vivo	2013
Dr Sarah Watkins Dr Gillian Borthwick Rachael Oakenfull Dr Andrew Robson Professor Helen Arthur et al.	Angiotensin II-induced cardiomyocyte hypertrophy in vitro is TAK1-dependent and Smad2/3-independent	2012
Dr Rachael Redgrave Dr Benjamin Davison Dr Muhammad Amirrasouli Professor Bernard Keavney Professor Andrew Blamire et al.	Cardiosphere-Derived Cell Transplantation Rescues Cardiac Function Post-MI Independently of Endoglin Expression	2012
Kathleen Allinson Professor Helen Arthur	Endothelial Expression of TGF beta Type II Receptor Is Required to Maintain Vascular Integrity during Postnatal Development of the Central Nervous System	2012
Professor Helen Arthur	Minimal Homozygous Endothelial Deletion of Eng with VEGF Stimulation Is Sufficient to Cause Cerebrovascular Dysplasia in the Adult Mouse	2012
Dr Elise Glen Dr Ana Topf Dr Darroch Hall Dr John O'Sullivan Linda Sneddon et al.	Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation	2012
Dr Marwa Mahmoud Professor Helen Arthur	Angiogenesis Regulation by TGFbeta signalling: clues from an inherited vascular disease	2011
Dr Benjamin Davison Dr Rachael Redgrave Professor Bernard Keavney Professor Andrew Blamire Professor Helen Arthur et al.	In vivo depletion of endoglin results in significant left ventricular remodelling	2011
Dr Elise Glen Dr Ana Topf Dr Darroch Hall Dr John O'Sullivan Linda Sneddon et al.	Non-synonymous SMAD6 mutations impaired inhibition of BMP signalling in patients with congenital cardiovascular malformation	2011
Professor Helen Arthur Dr Simon Bamforth	TGF beta Signaling and Congenital Heart Disease: Insights from Mouse Studies	2011
Dr Sarah Watkins Dr Gillian Borthwick Professor Helen Arthur	The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro	2011
Professor Helen Arthur	VEGF Induced More Severe Cerebrovascular Dysplasia in the Adult Mouse Brain with Regional Deletion of Alk1 Compared to Endoglin	2011
Dr Marwa Mahmoud Kathleen Allinson Dr Jason Zhai Rachael Oakenfull Professor Helen Arthur et al.	Pathogenesis of Arteriovenous Malformations in the Absence of Endoglin	2010
Professor Helen Arthur	Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia	2010
Dr Andrew Robson Kathleen Allinson Professor Bob Anderson Professor Deborah Henderson Professor Helen Arthur et al.	The TGF beta Type II Receptor Plays a Critical Role in the Endothelial Cells During Cardiac Development	2010
Dr Honey Thomas Professor John Dark Professor Helen Arthur Professor Bernard Keavney	Circulating endothelial progenitor cell numbers are not associated with donor organ age or allograft vasculopathy in cardiac transplant recipients	2009
Dr Marwa Mahmoud Dr Gillian Borthwick Professor Helen Arthur	Endoglin and activin receptor-like-kinase 1 are co-expressed in the distal vessels of the lung: implications for two familial vascular dysplasias, HHT and PAH	2009
Dr Honey Thomas Dr Peter Avery Dr Javed Ahmed Dr Richard Edwards Professor Azfar Zaman et al.	Local vessel injury following percutaneous coronary intervention does not promote early mobilisation of endothelial progenitor cells in the absence of myocardial necrosis	2009
Dr Rachael Redgrave Dr Michael Cunnington Dr Peter Avery Professor Bernard Keavney Professor Helen Arthur et al.	Circulating endothelial progenitor cells exhibit diurnal variation	2008
Dr Rachael Redgrave Dr Michael Cunnington Professor Bernard Keavney Professor Helen Arthur	Circulating endothelial progenitor cells from healthy individuals exhibit diurnal variation	2008
Dr Honey Thomas Professor Helen Arthur Professor Bernard Keavney	Investigation of relationships between circulating endothelial progenitor cell numbers, cardiac allograft vasculopathy and donor heart age in cardiac transplant recipients	2008
Professor Helen Arthur	Extracellular control of TGFβ signalling in vascular development and disease	2007
Kathleen Allinson Professor Helen Arthur	Generation of a floxed allele of the mouse endoglin gene	2007
Dr Sarah Watkins Dr Leon Jonker Professor Helen Arthur	A direct interaction between TGFβ activated kinase 1 and the TGFβ type II receptor: Implications for TGFβ signalling and cardiac hypertrophy	2006
Professor Helen Arthur	Endoglin has a crucial role in blood cell-mediated vascular repair	2006
Dr Gillian Borthwick Dr Sarah Johnson Professor Sir John Burn Professor Helen Arthur	Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a Cox-independent mechanism	2006
Professor Helen Arthur	TGF-beta in endothelial cell function and vascular development	2005
Dr Sarah Watkins Dr Leon Jonker Professor Helen Arthur	TGFbeta typeII receptor interacts with TGFbeta activated kinase (TAK1): Implications for controlling cardiac hypertrophy	2005
Dr Sarah Johnson Professor Helen Arthur Professor Sir John Burn	Bowel cancer prevention: Aspirin induces Cox-2 independent endothelial cell apoptosis facilitating angiogenesis arrest	2004
Dr Leon Jonker Professor Helen Arthur	Defective paracrine signalling by TGFβ in yolk sac vasculature of endoglin mutant mice: A paradigm for hereditary haemorrhagic telangiectasia	2004
Dr Leon Jonker Professor Helen Arthur	Endoglin promotes endothelial cell proliferation and TGF-β/ALK1 signal transduction	2004
Professor Helen Arthur	Vascular Endothelial Growth Factor Induces Abnormal Microvasculature in the Endoglin Heterozygous Mouse Brain	2004
Sanjay Chaudhri Professor Helen Arthur Dr Mark Bennett Alan Horgan	Angiogenesis in rectal cancer: Can preoperative endoscopic biopsies predict tumour behaviour?	2003
Professor Helen Arthur	Investigation of TGF-beta plasma levels as a modifier of the phenotype of hereditary hemorrhagic telangiectasia	2003
Evelyn Torsney Dr Richard Charlton Professor Sir John Burn Professor Helen Arthur	Mouse model for hereditary hemorrhagic telangiectasia has a generalized vascular abnormality	2003
Professor Helen Arthur Professor Sir John Burn Ronald Wilson	Non steroidal anti-inflammatory drugs and colorectal cancer prevention: Evidence for a cox-2 independent anti-angiogenic effect	2003
Dr Christopher Kettle Dr Trevor Jowett Professor Helen Arthur	The pattern of segment formation, as revealed by engrailed expression, in a centipede with a variable number of segments	2003
Professor Helen Arthur Evelyn Torsney Professor Sir John Burn	The role of endoglin in cardiovascular development	2003
Dr Leon Jonker Professor Helen Arthur	Endoglin expression in early development is associated with vasculogenesis and angiogenesis	2002
Evelyn Torsney Dr Richard Charlton Professor Helen Arthur	Inducible expression of human endoglin during inflammation and wound healing in vivo	2002
Evelyn Torsney Dr Richard Charlton Professor Helen Arthur	Endoglin, a gene required for murine embryonic vasculogenesis, is upregulated in angiogenesis in human inflammatory disease: Studies using a 'knockout' mouse model (the 'Cookson Mouse')	2001
Evelyn Torsney Dr Richard Charlton Professor Helen Arthur	An antibody to Endoglin/CD105 (SN6h): A marker for endothelial cells in chronic inflammatory disease	2000
Professor Helen Arthur Glenn Renforth Dr David Wilson Evelyn Torsney Dr Trevor Jowett et al.	Endoglin, an ancillary TGFβ receptor, is required for extraembryonic angiogenesis and plays a key role in heart development	2000
Professor Helen Arthur Dr David Wilson Evelyn Torsney Glenn Renforth Professor Sir John Burn et al.	Progress towards developing a mouse model of Hereditary Haemorrhagic Telangiectasia	1999