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Lookup NU author(s): Professor Chris Day
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While the majority of those with non-alcoholic fatty liver disease (NAFLD) will have simple hepatic steatosis, a minority will develop progressive steatohepatitis. Family studies and inter-ethnic variations in susceptibility suggest that genetic factors may be important in determining disease risk. Although no genetic associations with advanced NAFLD have been replicated in large studies, preliminary data suggest that polymorphisms in genes controlling lipid metabolism, pro-inflammatory cytokines, fibrotic mediators and oxidative stress may be associated with steatohepatitis and/or fibrosis. Recent whole genome-wide scans have identified genes contributing to inherited susceptibility to steatosis and it seems likely that similar approaches will identify genes associated with disease progression in the near future. Copyright (C) 2010 S. Karger AG, Basel
Author(s): Day CP
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: Digestive Diseases: Falk Workshop on Immunology and Liver Disease
Year of Conference: 2010
Pages: 255-260
ISSN: 0257-2753
Publisher: S. Karger AG
URL: http://dx.doi.org/10.1159/000282098
DOI: 10.1159/000282098
Library holdings: Search Newcastle University Library for this item
ISBN: 14219875
