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MYCN oncoprotein targets and their therapeutic potential

Lookup NU author(s): Dr Emma Bell, Dr Lindi Chen, Professor John LunecORCiD, Professor Deborah Tweddle

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Abstract

The MYCN oncogene encodes a transcription factor which is amplified in up to 40% of high risk neuroblastomas. MYCN amplification is a well-established poor prognostic marker in neuroblastoma, however the role of MYCN expression and the mechanisms by which it acts to promote an aggressive phenotype remain largely unknown. This review discusses the current evidence identifying the direct and indirect downstream transcriptional targets of MYCN from recent studies, with particular reference to how MYCN affects the cell cycle, DNA damage response, differentiation and apoptosis in neuroblastoma. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Bell E, Chen LD, Liu T, Marshall GM, Lunec J, Tweddle DA

Publication type: Review

Publication status: Published

Journal: Cancer Letters

Year: 2010

Volume: 293

Issue: 2

Pages: 144-157

Print publication date: 01/07/2010

ISSN (print): 0304-3835

ISSN (electronic): 1872-7980

Publisher: ELSEVIER IRELAND LTD

URL: http://dx.doi.org/10.1016/j.canlet.2010.01.015

DOI: 10.1016/j.canlet.2010.01.015

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