Lookup NU author(s): Dr Gendie Lash,
Dr Katsuhiko Naruse,
Professor Stephen Robson,
Dr Roger Searle,
Dr Judith Bulmer
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Angiogenesis is a key feature of placental and uterine development in early pregnancy. We hypothesized that trophoblast cells produce angiogenic growth factors, and that expression differs between villous cytotrophoblast (CTB) and extravillous trophoblast (EVT) cells. Fourteen angiogenic growth factors were measured by multiplex growth factor analysis or ELISA in tissue culture supernatants from EVT and CTB from pregnancies at 8-10 and 12-14 weeks' gestation. Gestational age and cell type differences were observed. EVT and CTB are major producers of angiogenic growth factors that likely contribute to placental vascular development and spiral artery remodeling. (C) 2010 Elsevier Ltd. All rights reserved.
Author(s): Lash GE, Naruse K, Innes BA, Robson SC, Searle RF, Bulmer JN
Publication type: Article
Publication status: Published
Print publication date: 24/03/2010
ISSN (print): 0143-4004
ISSN (electronic): 1532-3102
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