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Lookup NU author(s): Mike Cole,
Professor Alan Boddy,
Dr Pamela Kearns,
Professor Andrew Pearson,
Professor Gareth Veal
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Pharmacological studies of anti-cancer agents in children are essential to determine their clinical safety and efficacy, both of which can differ considerably from that observed in adults. However, the potential clinical impact of taking blood samples, in addition to those required for standard clinical practice is commonly a concern for both medical and allied staff and parents. Frequently quoted safe limits of 3%-5% of total blood volume taken on any one study day are not based on published data and may not be acceptable for all patients. This article reviews some of the reasons why clinical pharmacology data for anti-cancer drugs is often lacking in a paediatric patient population, summarises data from a retrospective study investigating the potential impact of repeated blood sampling for research purposes and discusses how this issue may be more systematically addressed in future studies. Research involving children with cancer should be limited to those studies addressing key scientific questions and should be designed to limit both the number and volume of blood samples required. © 2005 Wiley-Liss, Inc.
Author(s): Pearson ADJ; Veal GJ; Boddy AV; Kearns P; Cole M; Parry A; Price L; Teh KH
Publication type: Article
Publication status: Published
Journal: Pediatric Blood and Cancer
Date deposited: 04/08/2010
ISSN (print): 1545-5009
ISSN (electronic): 1545-5017
Publisher: John Wiley & Sons, Inc.
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