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Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci
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A large series of plasma cell dyscrasias (n=2207) was examined for translocations which deregulate the MAF genes, t(14;20)(q32;q12) and t(14;16)(q32;q23), and their disease behavior was compared to a group characterized by the t(4;14)(p16;q32) where CCND2 is also up-regulated. The t(14;20) showed low prevalence in myeloma (27/1830, 1.5%) and smoldering myeloma (1/148, <1%) with a higher incidence in MGUS (9/193, 5% P=0.005). Strong associations. with del(13) (76%), non-hyperdiploidy (83%) and gain of 1q (58%) were seen but no association with an IgA M-protein or absence of bone disease was noted. All three translocations were associated with poor outcome in myeloma, but strikingly all t(14;20) MGUS/smoldering myeloma cases (n=10) had stable, low level disease. In contrast, the 10 t(14;16) and 25 t(4;14) MGUS/smoldering myeloma cases were associated with both evolving and non-evolving disease. None of the associated genetic abnormalities helped to predict for progression from MGUS or smoldering myeloma. (Clinicaltrials.gov identifier: ISRCTN 68454111; UKCRN ID 1176)
Author(s): Ross FM, Chiecchio L, Dagrada G, Protheroe RKM, Stockley DM, Harrison CJ, Cross NCP, Szubert AJ, Drayson MT, Morgan GJ, UK Myeloma Forum
Publication type: Article
Publication status: Published
Journal: Haematologica: The Haematology Journal
Year: 2010
Volume: 95
Issue: 7
Pages: 1221-1225
Print publication date: 21/04/2010
ISSN (print): 0390-6078
ISSN (electronic): 1592-8721
Publisher: Fondazione Ferrata Storti
URL: http://dx.doi.org/10.3324/haematol.2009.016329
DOI: 10.3324/haematol.2009.016329
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