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Browsing publications by Professor Christine Harrison FRCPath FMedSci.

Newcastle AuthorsTitleYearFull text
Dr Carmela Ciardullo
Dr Katarzyna Szoltysek
Dr Peixun Zhou
Dr Elaine Willmore
Dr Amir Enshaei
et al.
Low BACH2 expression predicts adverse outcome in chronic lymphocytic leukaemia2022
Professor Anthony Moorman
Dr Grace Antony
Ellie Butler
Dr Amir Enshaei
Professor Christine Harrison FRCPath FMedSci
et al.
Time to Cure for Childhood and Young Adult Acute Lymphoblastic Leukemia Is Independent of Early Risk Factors: Long-Term Follow-Up of the UKALL2003 Trial2022
Professor Christine Harrison FRCPath FMedSci
Cytogenetics of pediatric acute myeloid leukemia: A review of the current knowledge2021
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study2021
Professor Christine Harrison FRCPath FMedSci
Prevention of childhood leukaemia by lifestyle changes2021
Dr Amir Enshaei
Professor Christine Harrison FRCPath FMedSci
Claire Schwab
Professor Anthony Moorman
A validated novel continuous prognostic index to deliver stratified medicine in pediatric acute lymphoblastic leukemia2020
Professor Anthony Moorman
Claire Schwab
Emily Winterman
Dr Frederik van Delft
Professor Christine Harrison FRCPath FMedSci
et al.
Adjuvant tyrosine kinase inhibitor therapy improves outcome for children and adolescents with acute lymphoblastic leukaemia who have an ABL-class fusion2020
Dr Matthew Bashton
Robin Hollis
Dr Sarra Ryan
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
et al.
Concordance of copy number abnormality detection using SNP arrays and Multiplex Ligation-dependent Probe Amplification (MLPA) in acute lymphoblastic leukaemia2020
Dr Katarzyna Szoltysek
Dr Carmela Ciardullo
Dr Peixun Zhou
Dr Anna Walaszczyk
Dr Elaine Willmore
et al.
Dap kinase-related apoptosis-inducing protein kinase 2 (Drak2) is a key regulator and molecular marker in chronic lymphocytic leukemia2020
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
Design of a Comprehensive Fluorescence in Situ Hybridization Assay for Genetic Classification of T-Cell Acute Lymphoblastic Leukemia2020
Professor Christine Harrison FRCPath FMedSci
MLPA and DNA index improve the molecular diagnosis of childhood B-cell acute lymphoblastic leukemia2020
Dr Matthew Bashton
Professor Christine Harrison FRCPath FMedSci
IKZF1 Deletions with COBL Breakpoints Are Not Driven by RAG-Mediated Recombination Events in Acute Lymphoblastic Leukemia2019
Professor James Allan
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Author correction: Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia2019
Alex Newman
Dr Masood Zaka
Dr Peixun Zhou
Dr Amy Erhorn
Amy Barnard
et al.
Biallelic Inactivation of TP53 is Associated with an Increased Risk of Relapse in Paediatric B-Cell Non-Hodgkin Lymphoma(B-NHL)2019
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia2019
Dr Paul Sinclair
Dr Sarra Ryan
Dr Matthew Bashton
Shaun Hollern
Rebecca Hanna
et al.
SH2B3 inactivation through CN-LOH-12q is uniquely associated with B-cell precursor ALL with iAMP21 or other chromosome 21 gain2019
Dr Helen Blair
Professor Christine Harrison FRCPath FMedSci
Dr Lisa Russell
Single cell analysis identifies CRLF2 rearrangements as both early and late events in Down syndrome and non-Down syndrome acute lymphoblastic leukaemia2019
Dr Tom Creasey
Dr Amir Enshaei
Kathryn Watts
Gavin Cuthbert
Claire Schwab
et al.
Single Nucleotide Polymorphism Array-Based Signature of Genetic Ploidy Groups in Acute Lymphoblastic Leukemia2019
Dr Lina Hamadeh
Dr Amir Enshaei
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
et al.
Validation of the United Kingdom copy-number alteration classifier in 3239 children with B-cell precursor ALL2019
Dr Ruth Cranston
Dr Paul Sinclair
Dr Matthew Bashton
Dr Matthew Selby
Professor Christine Harrison FRCPath FMedSci
et al.
A Genome-Wide CRISPR Screen Implicates MYC Dysregulation in TCF3-PBX1 B-ALL2018
Alex Newman
Dr Masood Zaka
Dr Peixun Zhou
Dr Amy Erhorn
Dr Rachel Crossland
et al.
Biallelic inactivation of TP53 is associated with an increased risk of relapse in paediatric B-cell non-Hodgkin lymphoma (B-NHL)2018
Dr Paul Sinclair
Dr Helen Blair
Dr Sarra Ryan
Dr Lars Buechler
Joanna Cheng
et al.
Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 212018
Professor James Allan
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia2018
Alex Newman
Dr Peixun Zhou
Dr Masood Zaka
Professor Christine Harrison FRCPath FMedSci
Dr Simon Bomken
et al.
Genomic landscape of adult and paediatric B-cell Non-Hodgkin lymphoma2018
Professor Christine Harrison FRCPath FMedSci
Dr Simona Constantinescu
Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL2018
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL2018
Dr Luca Ermini
Dr Frederik van Delft
Dr Sarah Jenkinson
Professor Christine Harrison FRCPath FMedSci
The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia2018
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling2018
Professor Anthony Moorman
Professor Julie Irving
Professor James Allan
Professor Christine Harrison FRCPath FMedSci
A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.12017
Dr Britta Vormoor
Professor Gareth Veal
Melanie Griffin
Professor Julie Irving
Lynne Minto
et al.
A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia2017
Dr Lucy Chilton
Professor Christine Harrison FRCPath FMedSci
Daniel Murdy
Professor Anthony Moorman
Clinical relevance of failed and missing cytogenetic analysis in acute myeloid leukaemia2017
Zach Dixon
Dr Lindsay Nicholson
Elizabeth Matheson
Dr Paul Sinclair
Professor Christine Harrison FRCPath FMedSci
et al.
CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response2017
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
Digital Multiplex Ligation-Dependent Probe Amplification for Detection of Key Copy Number Alterations in T- and B-Cell Lymphoblastic Leukemia2017
Dr Amir Enshaei
Professor Christine Harrison FRCPath FMedSci
Dr Sujith Samarasinghe
Claire Schwab
Professor Anthony Moorman
et al.
Genotype-Specific Minimal Residual Disease Interpretation Improves Stratification in Pediatric Acute Lymphoblastic Leukemia2017
Claire Schwab
Dr Lucy Chilton
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Intragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia?2017
Professor Christine Harrison FRCPath FMedSci
Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukemia2017
Professor Anthony Moorman
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
Dr Sujith Samarasinghe
Use of minimal residual disease assessment to redefine induction failure in pediatric acute lymphoblastic leukemia2017
Claire Schwab
Sarra Ryan
Dr Lucy Chilton
Alannah Elliott
James Murray
et al.
EBF1-PDGFRB fusion in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL): genetic profile and clinical implications2016
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Acute lymphoblastic leukaemia2016
Dr Carmela Ciardullo
Dr Elaine Willmore
Dr Amir Enshaei
Dr Peixun Zhou
Dr Vikki Rand
et al.
BACH2 and BCL6 Cooperatively Fuction as Tumour Suppressors in CLL2016
Dr Lisa Russell
Lisa Jones
Dr Amir Enshaei
Dr Stefano Tonin
Sarra Ryan
et al.
Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia2016
Professor Christine Harrison FRCPath FMedSci
Chronic Myeloid Leukemia: Reminiscences And Dreams2016
Professor Christine Harrison FRCPath FMedSci
Claire Schwab
Constitutional abnormalities of chromosome 21 predispose to iAMP21-acute lymphoblastic leukaemia2016
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemia2016
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
Genetic characterization and therapeutic targeting of MYC translocated pediatric T-cell acute lymphoblastic leukemia2016
Dr Carmela Ciardullo
Dr Elaine Willmore
Dr Peixun Zhou
Dr Vikki Rand
Professor Christine Harrison FRCPath FMedSci
et al.
Impact of the apoptotic regulator DRAK2 in chronic lymphocytic leukemia2016
Dr Carmela Ciardullo
Dr Peixun Zhou
Dr Elaine Willmore
Professor Christine Harrison FRCPath FMedSci
Emeritus Professor Andy Hall
et al.
Impact of the apoptotic regulator DRAK2 in chronic lymphocytic leukemia2016
Professor Julie Irving
Dr Amir Enshaei
Dr Amy Erhorn
Lynne Minto
Claire Schwab
et al.
Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukaemia2016
Dr Lucy Chilton
Professor Christine Harrison FRCPath FMedSci
The prognostic significance of trisomy 4 in acute myeloid leukaemia is dependent on age and additional abnormalities2016
Dr Sarra Ryan
Elizabeth Matheson
Dr Paul Sinclair
Dr Matthew Bashton
Claire Schwab
et al.
The role of the RAS pathway in iAMP21-ALL2016
Professor Christine Harrison FRCPath FMedSci
Blood Spotlight on iAMP21 acute lymphoblastic leukemia (ALL), a high-risk pediatric disease2015
Dr Mark Wade
Dr Nicola Sunter
Dr Sarah Fordham
Anna Long
Dino Mašić
et al.
c-MYC is a radiosensitive locus in human breast cells2015
Dr Paul Sinclair
Joanna Cheng
Prahlad Raninga
Rebecca Hanna
Shaun Hollern
et al.
A Targeted Functional Clone Tracking Assay for the Identification of Tumour Suppressor Genes in BCP- ALL Implicates the Transcription Factors FOXO3 and PRDM12015
Professor Christine Harrison FRCPath FMedSci
Acute lymphoblastic leukemia2015
Professor Christine Harrison FRCPath FMedSci
Acute myeloid leukemia2015
Professor Christine Harrison FRCPath FMedSci
Advances in the Genetics of Childhood Leukaemia: a Success Story2015
Dr Al Gabriel
Dr Amir Enshaei
Jennifer Taylor
Dr Amy Erhorn
Claire Schwab
et al.
Age specific incidence of partner gene and secondary abnormalities in MLL positive acute lymphoblastic leukaemia (ALL)2015
Dr Lisa Russell
Lisa Jones
Dr Amir Enshaei
Jamie Rutherford
Dr Stefano Tonin
et al.
Clincial and Genetic Landscapes Differ Between IGH-CRLF2 and P2RY8-CRLF2 Acute Lymphoblastic Leukaemia2015
Dr Lisa Russell
Lisa Jones
Dr Amir Enshaei
Dr Stefano Tonin
Dr Sarra Ryan
et al.
Clincial and Genetic Landscapes Differ Between IGH-CRLF2 and P2RY8-CRLF2 Acute Lymphoblastic Leukaemia2015
Professor Christine Harrison FRCPath FMedSci
Clinical Impact of Additional Cytogenetic Aberrations, cKIT and RAS Mutations, and Treatment Elements in Pediatric t(8;21)-AML: Results From an International Retrospective Study by the International Berlin-Frankfurt-Munster Study Group2015
Professor Anthony Moorman
Professor Julie Irving
Dr Amir Enshaei
Dr Amy Erhorn
Lynne Minto
et al.
Composite Index for Risk Prediction in Relapsed Childhood Acute Lymphoblastic Leukaemia2015
Dr Al Gabriel
Fadhel Alsaid Naji
Dr Ed Schwalbe
Dr Sirintra Nakjang
Dr Simon Cockell
et al.
Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia2015
Dr Dino Masic
Dr Amir Enshaei
Lisa Jones
Professor Christine Harrison FRCPath FMedSci
Dr Lisa Russell
et al.
Genetic Characterisation of Immunoglobulin Heavy Chain Locus CCAAT Enhancer-Binding Protein Translocated Acute Lymphoblastic Leukaemia2015
Dino Mašić
Dr Amir Enshaei
Lisa Jones
Professor Christine Harrison FRCPath FMedSci
Dr Lisa Russell
et al.
Genetic Characterisation of Immunoglobulin Heavy Chain Locus CCAAT Enhancer-Binding Protein Translocated Acute Lymphoblastic Leukaemia2015
Dr Amir Enshaei
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Dr Sujith Samarasinghe
Integration of Minimal Residual Disease with Other Patient Risk Factors Identifies a Population with Very Poor Overall Survival in Pediatric ALL: Results from the UKALL 2003 Trial2015
Dr Amir Enshaei
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Dr Sujith Samarasinghe
Long Term Overall Survival of Greater Than 98% in Childhood ALL Patients with Good Risk Features and Low Risk MRD: Results from a Large Multi-Center Randomized Controlled Trial, UKALL 20032015
Dr Amir Enshaei
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Dr Sujith Samarasinghe
Long Term Overall Survival of Greater Than 98% in Childhood ALL Patients with Good Risk Features and Low Risk MRD:A Results from a Large Multi-Center Randomized Controlled Trial, UKALL 20032015
Dr Lucy Chilton
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Prognostic Significance and Risk Stratification in Acute Myeloid Leukaemia Patients in the Absence of Successful Cytogenetic Analysis2015
Dr Lindsay Nicholson
Elizabeth Matheson
Lynne Minto
Christopher Keilty
Maryna Sanichar
et al.
Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition2015
Professor Julie Irving
Elizabeth Matheson
Helen Blair
Marian Case
Isabella Swidenbank
et al.
Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition. Blood. 2014;124(23):3420-34302015
Professor Christine Harrison FRCPath FMedSci
Refinement of IKZF1 status in pediatric Philadelphia-positive acute lymphoblastic leukemia2015
Dr Amir Enshaei
Claire Schwab
Dr Lucy Chilton
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
et al.
Risk Factor Analysis in Paediatric Acute Lymphoblastic Leukaemia with High Hyperdiploidy2015
Claire Schwab
Alannah Elliott
Dr Lucy Chilton
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
et al.
Targeted Sequencing Identifies Association Between IL7R-JAK Mutations And Epigenetic Modulators In T-Cell Acute Lymphoblastic Leukemia.2015
Professor Anthony Moorman
Professor Julie Irving
Professor James Allan
Professor Christine Harrison FRCPath FMedSci
The 9p21.3 risk of childhood acute lymphoblastic leukaemia is explained by a rare high-impact variant in CDKN2A2015
Dr Jeyanthy Eswaran
Dr Paul Sinclair
Professor Olaf Heidenreich
Professor Julie Irving
Dr Lisa Russell
et al.
The pre-B-cell receptor checkpoint in acute lymphoblastic leukaemia2015
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling2015
Dr Lisa Russell
Dr Amir Enshaei
Lisa Jones
Dr Amy Erhorn
Dr Dino Masic
et al.
IGH@ Translocations Are Prevalent in Teenagers and Young Adults With Acute Lymphoblastic Leukemia and Are Associated With a Poor Outcome2014
Lisa Jones
Professor Christine Harrison FRCPath FMedSci
Dr Lisa Russell
IGH@ Translocations Co-exist With Other Primary Rearrangements in B-cell Precursor Acute Lymphoblastic Leukemia2014
Professor Christine Harrison FRCPath FMedSci
IKZF1 status as a prognostic feature in BCR-ABL1-positive childhood ALL2014
Professor Anthony Moorman
Dr Amir Enshaei
Claire Schwab
Dr Lucy Chilton
Alannah Elliott
et al.
A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia2014
Professor Christine Harrison FRCPath FMedSci
Clinical Impact of Additional Cytogenetic Aberrations, cKIT- and RAS Mutations and Other Factors in Pediatric t(8;21)-AML2014
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
CMYC-translocations in t-cell acute lymphoblastic leukemia2014
Sarra Ryan
Professor Anthony Moorman
Dr Richard McNally
Professor Bryan Young
Dr Paul Sinclair
et al.
Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia2014
Claire Schwab
Dr Sarra Ryan
Professor Christine Harrison FRCPath FMedSci
Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia2014
Claire Schwab
Becca Andrews
Dr Lucy Chilton
Alannah Elliott
Gerald Keil
et al.
EBF1-PDGFRB Fusion in Paediatric Acute Lymphoblastic Leukaemia (ALL): Genetic Profile and Clinical Implications2014
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
Genetic profile of T-cell acute lymphoblastic leukemias with MYC translocations2014
Dr Lucy Chilton
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
High hyperdiploidy among adolescents and adults with acute lymphoblastic leukaemia (ALL): cytogenetic features, clinical characteristics and outcome2014
Dr Lucy Chilton
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Hyperdiploidy with 49-65 chromosomes represents a heterogeneous cytogenetic subgroup of acute myeloid leukemia with differential outcome.2014
Dr Jeyanthy Eswaran
Dr Paul Sinclair
Dr Sirintra Nakjang
Professor Christine Harrison FRCPath FMedSci
Identification of Cmtm Family Proteins As Tumor Suppressor and Membrane Regulator in B Cell Precursor Acute Lymphoblastic Leukemia2014
Professor Christine Harrison FRCPath FMedSci
No chromosome arm unturned: in memory of Roland Berger 1934-20122014
Jake Clayton
Joanna Cheng
Dr Sarra Ryan
Professor Christine Harrison FRCPath FMedSci
Dr Paul Sinclair
et al.
Oncogenomic Screening Strategies to Identify Tumour Suppressor Genes on Chromosome 12 in Acute Myeloid Leukaemia2014
Professor Julie Irving
Elizabeth Matheson
Dr Helen Blair
Marian Case
Isabella Swidenbank
et al.
Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition2014
Professor Christine Harrison FRCPath FMedSci
Claire Schwab
Refinement of IKZF1 Genomic Status in Pediatric Philadelphia Positive Acute Lymphoblastic Leukemia2014
Claire Schwab
Becca Andrews
Dr Lucy Chilton
Alannah Elliott
Dr Stacey Richardson
et al.
SSBP2-CSF1R Is a Recurrent Fusion in B-Other Acute Lymphoblastic Leukaemia with Variable Clinical Outcome2014
Alannah Elliott
Dr Lucy Chilton
Professor Christine Harrison FRCPath FMedSci
Targeted resequencing of 115 genes identifies association between jak3 and epigenetic mutations in t-cell acute lymphoblastic leukemia2014
Dr Frederik van Delft
Professor Christine Harrison FRCPath FMedSci
The Sub-Clonal Complexity of STIL-TAL1 T-ALL2014
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
BTG1 deletions do not predict outcome in Down syndrome acute lymphoblastic leukemia2013
Dr Halima Al-shehhi
Claire Schwab
Dr Amy Erhorn
Dr Al Gabriel
Professor Christine Harrison FRCPath FMedSci
et al.
Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia2013
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Claire Schwab
Dr Lucy Chilton
An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome2013
Claire Schwab
Dr Lucy Chilton
Heather Morrison
Lisa Jones
Dr Halima Al-shehhi
et al.
Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features2013
Professor Christine Harrison FRCPath FMedSci
IKZF1 Deletions Predict Relapse in BCR-ABL1-Positive Childhood Acute Lymphoblastic Leukemia Patients Who Were Treated With or Without Imatinib2013
Dr Lisa Russell
Professor Christine Harrison FRCPath FMedSci
Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL2013
Dr Amir Enshaei
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Long-term follow-up of ETV6-RUNX1 ALL reveals that NCI risk, rather than secondary genetic abnormalities, is the key risk factor2013
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Loss of chromosomes is the primary event in near-haploid and low-hypodiploid acute lymphoblastic leukemia2013
Professor Christine Harrison FRCPath FMedSci
Pediatric acute myeloid leukemia with t(8;16)(p11;p13), a distinct clinical and biological entity: a collaborative study by the International-Berlin-Frankfurt-Munster AML-study group2013
Professor Christine Harrison FRCPath FMedSci
Pediatric Acute Myeloid Leukemia with T(8;16)(P11;P13); A Distinct Clinical and Biological Entity. Results of a Collaborative Study by the International Berlin-Frankfurt-Munster AML Study Group ENTITY. RESULTS OF A COLLABORATIVE STUDY BY THE INTERNATIONAL BERLIN- FRANKFURT-MUNSTER AML STUDY GROUP2013
Professor Anthony Moorman
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
Risk-Directed Treatment Intensification Significantly Reduces the Risk of Relapse Among Children and Adolescents With Acute Lymphoblastic Leukemia and Intrachromosomal Amplification of Chromosome 21: A Comparison of the MRC ALL97/99 and UKALL2003 Trials2013
Professor Christine Harrison FRCPath FMedSci
Targeting signaling pathways in acute lymphoblastic leukemia: new insights2013
Dr Emma Fairhall
Dr Michelle Charles
Karen Wallace
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
et al.
The B-13 hepatocyte progenitor cell resists pluripotency induction and differentiation to non-hepatocyte cells.2013
Professor Anthony Moorman
Dr Lucy Chilton
Dr Amir Enshaei
Professor Christine Harrison FRCPath FMedSci
The clinical characteristics, therapy and outcome of 85 adults with acute lymphoblastic leukemia and t(4;11)(q21;q23)/MLL-AFF1 prospectively treated on UKALLXII/ECOG29932013
Professor Anthony Moorman
Dr Lucy Chilton
Dr Amir Enshaei
Professor Christine Harrison FRCPath FMedSci
The clinical characteristics, therapy and outcome of 85 adults with acute lymphoblastic leukemia and t(4;11)(q21;q23)/MLL-AFF1 prospectively treated in the UKALLXII/ECOG2993 trial2013
Dr Emma Fairhall
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
Dr Karen Wallace
Professor Matthew Wright
et al.
The Hepatic Progenitor B-13 Cell Line Engrafts into the Mouse Liver and Transdifferentiates in Vivo2013
Professor Anthony Moorman
Claire Schwab
Hannah Ensor
Dr Lisa Russell
Heather Morrison
et al.
IGH@ Translocations, CRLF2 Deregulation and Microdeletions in Adolescents and Adults with Acute Lymphoblastic Leukemia2012
Professor Graham Jackson
Professor Christine Harrison FRCPath FMedSci
Professor Simon Bailey
Burkitt's lymphoma2012
Professor Christine Harrison FRCPath FMedSci
Clinical Impact of Additional Cytogenetic Aberrations and Treatment in Pediatric t(8;21)-Positive AML: Results from an International Retrospective I-BFM-SG Study2012
Claire Schwab
Dr Lucy Chilton
Dr Amir Enshaei
Heather Morrison
Lisa Jones
et al.
Clinical Relevance of Genes Commonly Deleted in Childhood B-Cell Precursor ALL (BCP-ALL)2012
Professor Anthony Moorman
Dr Amir Enshaei
Dr Lucy Chilton
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
et al.
Delineation of Risk Factors in Paediatric Acute Lymphoblastic Leukaemia with Favourable Cytogenetics2012
Claire Schwab
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia2012
Claire Schwab
Dr Lucy Chilton
Heather Morrison
Lisa Jones
Dr Halima Al-shehhi
et al.
Genes Commonly Deleted in Childhood B-Cell Precursor ALL (BCP-ALL) Are Associated with Major Cytogenetic Subgroups2012
Professor Christine Harrison FRCPath FMedSci
Genomic Analysis Drives Tailored Therapy in Poor Risk Childhood Leukemia2012
Dr Lisa Russell
Lisa Jones
Dr Amy Erhorn
Dr Amir Enshaei
Dino Mašić
et al.
Immunoglobulin Heavy Chain Locus (IGH@) Translocations in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL): Incidence and Risk Stratification2012
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Claire Schwab
Intrachromosomal Amplification of Chromosome 21(iAMP21): Cytogenetic Characterisation and Outcome in Childhood B-Cell Precursor Acute Lymphoblastic Leukaemia (BCP-ALL). A Study On Behalf of the Ponte Di Legno International Childhood ALL Workshop2012
Dr Lisa Russell
Professor Christine Harrison FRCPath FMedSci
Leukemia Cells with a BCR-ABL1-Like signature and/or IKZF1 deletions, but Not High CRLF2 Expression, Are Predictive of an Unfavorable Prognosis in Childhood B Cell Precursor Acute Lymphoblastic Leukemia2012
Hannah Ensor
Professor Christine Harrison FRCPath FMedSci
Molecular versus flow cytometric MRD analysis - is there an explanation for discrepancies?2012
Dr Lisa Russell
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations2012
Hannah Ensor
Claire Schwab
Dr Lisa Russell
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
et al.
Treatment outcome of CRLF2-rearranged childhood acute lymphoblastic leukaemia: a comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups2012
Professor Christine Harrison FRCPath FMedSci
Acute Lymphoblastic Leukemia2011
Dr Paul Sinclair
Dr Vikki Rand
Hannah Ensor
Professor Christine Harrison FRCPath FMedSci
Analysis of a breakpoint cluster reveals insight into the mechanism of intrachromosomal amplification in a lymphoid malignancy2011
Hannah Ensor
Claire Schwab
Dr Lisa Russell
Heather Morrison
Dr Dino Masic
et al.
Demographic, clinical, and outcome features of children with acute lymphoblastic leukemia and CRLF2 deregulation: results from the MRC ALL97 clinical trial2011
Dr Vikki Rand
Dr Lisa Russell
Claire Schwab
Hannah Ensor
Professor Julie Irving
et al.
Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia2011
Professor Christine Harrison FRCPath FMedSci
How do we decipher the genetic profile of acute lymphoblastic leukaemia?2011
Professor Christine Harrison FRCPath FMedSci
Key pathways as therapeutic targets2011
Professor Christine Harrison FRCPath FMedSci
Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study2011
Professor Christine Harrison FRCPath FMedSci
Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11Q23/MLL-rearranged AML patients: Results of an international study2011
Dr Lindsay Nicholson
Charlotte Evans
Elizabeth Matheson
Lynne Minto
Christopher Keilty
et al.
Quantitative Proteomic Analysis Reveals Maturation As a Mechanism Underlying Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia and PAX5 As a Re-Sensitising Therapeutic Target2011
Dr Sarra Ryan
Dr Vikki Rand
Claire Schwab
Heather Morrison
Elizabeth Matheson
et al.
Ras Signalling Pathway and Novel Target Genes Related to Down Syndrome Contribute to the Development of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in iAMP21 Patients2011
Professor Christine Harrison FRCPath FMedSci
Results of a randomized trial in children with Acute Myeloid Leukaemia: Medical Research Council AML12 trial2011
Dr Lisa Russell
Professor Christine Harrison FRCPath FMedSci
A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia2010
Professor Christine Harrison FRCPath FMedSci
Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia2010
Dr Lisa Russell
Professor Christine Harrison FRCPath FMedSci
Activating mutation in the TSLPR gene in B-cell precursor lymphoblastic leukemia2010
Professor Christine Harrison FRCPath FMedSci
Clinical Impact of Additional Cytogenetic Aberrations and Complex Karyotype In Pediatric 11q23/MLL Rearranged AML Results from an International Retrospective Study2010
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Cytogenetics of Childhood Acute Myeloid Leukemia: United Kingdom Medical Research Council Treatment Trials AML 10 and 122010
Dr Nicholas Bown
Professor Christine Harrison FRCPath FMedSci
Cytogenetics of long-term survivors of ETV6-RUNX1 fusion positive acute lymphoblastic leukemia2010
Professor Christine Harrison FRCPath FMedSci
Detection of prognostically relevant genetic abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: recommendations from the Biology and Diagnosis Committee of the International Berlin-Frankfurt-Munster study group2010
Dr Lisa Russell
Professor Christine Harrison FRCPath FMedSci
Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group2010
Claire Schwab
Lisa Jones
Heather Morrison
Dr Sarra Ryan
Professor Christine Harrison FRCPath FMedSci
et al.
Evaluation of Multiplex Ligation-Dependent Probe Amplification as a Method for the Detection of Copy Number Abnormalities in B-Cell Precursor Acute Lymphoblastic Leukemia2010
Professor Christine Harrison FRCPath FMedSci
Genetic aberrations in paediatric acute leukaemias and implications for management of patients2010
Professor Christine Harrison FRCPath FMedSci
Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy2010
Professor Christine Harrison FRCPath FMedSci
Long-term follow-up of the United Kingdom medical research council protocols for childhood acute lymphoblastic leukaemia, 1980-20012010
Professor Christine Harrison FRCPath FMedSci
Claire Schwab
PHF6 mutations in T-cell acute lymphoblastic leukemia2010
Professor Anthony Moorman
Hannah Ensor
Dr Lucy Chilton
Claire Schwab
Professor Christine Harrison FRCPath FMedSci
et al.
Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial2010
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Refinement of cytogenetic classification in acute myeloid leukaemia: Determination of prognostic significance of rarer recurring chromosomal abnormalities amongst 5,876 younger adult patients treated in the UK Medical Research Council trials2010
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials2010
Professor Christine Harrison FRCPath FMedSci
The t(14;20) is a poor prognostic factor in myeloma but is associated with long-term stable disease in monoclonal gammopathies of undetermined significance2010
Professor Julie Irving
Professor James Allan
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk2010
Sarina Sulong
Professor Anthony Moorman
Professor Julie Irving
Marian Case
Professor Simon Bailey
et al.
A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups2009
Dr Lisa Russell
Professor Olaf Heidenreich
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
A novel translocation, t(14;19)(q32;p13) involving IGHalpha and the cytokine receptor for erythropoietin2009
Professor Christine Harrison FRCPath FMedSci
Acute Lymphoblastic Leukaemia2009
Professor Christine Harrison FRCPath FMedSci
Acute Myeloid Leukaemia2009
Professor Christine Harrison FRCPath FMedSci
Cytogenetics of paediatric and adolescent acute lymphoblastic leukaemia2009
Dr Lisa Russell
Professor Olaf Heidenreich
Professor Julie Irving
Professor Anthony Moorman
Heather Morrison
et al.
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia2009
Professor Christine Harrison FRCPath FMedSci
Down's Syndrome Acute Lymphoblastic Leukemia: A Highly Heterogeneous Disease Driven by an Aberrant CRLF2/JAK2 Cooperation - A Report from the Ibfm-Study GROUP2009
Professor Christine Harrison FRCPath FMedSci
FISH (Fluoresecence in situ Hybridization) as a Tool for the Detection of Significant Chromosomal Abnormalities in Childhood Leukaemia2009
Professor Christine Harrison FRCPath FMedSci
Frequent upregulation of MYC in plasma cell leukemia.2009
Professor Christine Harrison FRCPath FMedSci
Gain of 1q21 Does Not Predict for Immediate Progression in MGUS2009
Professor Anthony Moorman
Dr Michael Griffiths
Dr Tina Davies
Professor Christine Harrison FRCPath FMedSci
Heterogeneous breakpoints in patients with acute lymphoblastic leukemia and the dic(9;20)(p11-13;q11) show recurrent involvement of genes at 20q11.212009
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia2009
Professor Christine Harrison FRCPath FMedSci
Identification of Novel Prognostic Subgroups in Childhood 11Q23/MLL-Rearranged Acute Myeloid Leukemia2009
Professor Christine Harrison FRCPath FMedSci
ISCN (2009): Important revisions and new additions to molecular methods for copy number detection for cytogenetic analysis2009
Professor Christine Harrison FRCPath FMedSci
Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: sequential analysis of a single case2009
Professor Anthony Moorman
Dr Michael Griffiths
Professor Julie Irving
Professor Christine Harrison FRCPath FMedSci
Methylation of tumour suppressor gene promoters in the presence and absence of transcriptional silencing in high hyperdiploid acute lymphoblastic leukaemia2009
Professor Christine Harrison FRCPath FMedSci
Modeling the molecular consequences of unbalanced translocations in cancer: lessons from acute lymphoblastic leukemia2009
Professor Christine Harrison FRCPath FMedSci
Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study2009
Professor Christine Harrison FRCPath FMedSci
Novel prognostics subgroups in childhood 11Q23/MLL-rearranged acute myeloid leukemia as defined by translocation partners: A retrospective international study2009
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Prognostic Relevance of Cytogenetics in Childhood Acute Lymphoblastic Leukaemia (ALL): Final Results From MRC ALL972009
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Refinement of cytogenetic classification in AML: Determination of prognostic significance of rare recurring chromosomal abnormalities amongst 5635 younger adults treated in the UK MRC Trails2009
Professor Christine Harrison FRCPath FMedSci
Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia2009
Professor Christine Harrison FRCPath FMedSci
Strong association of the HLA-DP6 supertype with childhood leukaemia is due to a single allele, DPB1*06012009
Professor Christine Harrison FRCPath FMedSci
Timing of acquisition of deletion 13 in plasma cell dyscrasias is dependent on genetic context2009
Professor Christine Harrison FRCPath FMedSci
Topics in cytogenetics of acute leukaemias2009
Dr Vikki Rand
Dr Lisa Russell
Professor Julie Irving
Lisa Jones
Dr Dino Masic
et al.
What Is the Initiating Mechanism of iAMP21 in Childhood B Cell Precursor ALL?2009
Professor Christine Harrison FRCPath FMedSci
HLA-DPB1 supertype-associated protection from childhood leukaemia: relationship to leukaemia karyotype and implications for prevention2008
Professor Christine Harrison FRCPath FMedSci
Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome: an iBFM-SG study2008
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Cytogenetic-specific heterogeneity in the kinetics of minimal residual disease (MIRD) clearance in childhood lymphoblastic leukaemia (ALL)2008
Professor Christine Harrison FRCPath FMedSci
Disruption of ETV6 in intron 2 results in upregulatory and insertional events in childhood acute lymphoblastic leukaemia2008
Elizabeth Matheson
Lynne Minto
Professor Anthony Moorman
Emeritus Professor Andy Hall
Professor Julie Irving
et al.
Heterogeneous breakpoints target PAX5 in acute lymphoblastic leukaemia patients with dicentric chromosomes2008
Dr Lisa Russell
Professor Christine Harrison FRCPath FMedSci
IDENTIFICATION OF MULTIPLE NOVEL IGH@ TRANSLOCATIONS IN ADOLESCENT ACUTE LYMPHOBLASTIC LEUKAEMIA.2008
Dr Lisa Russell
Professor Anthony Moorman
Professor Olaf Heidenreich
Professor Christine Harrison FRCPath FMedSci
IGH@ Translocations Involving the Pseudoautosomal Region 1 (PAR1) of Both Sex Chromosomes Deregulate the Cytokine Receptor-Like Factor 2 (CRLF2) Gene in B Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL)2008
Professor Anthony Moorman
Sarina Sulong
Professor Julie Irving
Marian Case
Lynne Minto
et al.
Inactivation of CDKN2A in childhood acute lymphoblastic leukaemia (ALL) occurs principally by deletion and is strongly correlated with cytogenetic subgroups2008
Marian Case
Elizabeth Matheson
Lynne Minto
Professor Christine Harrison FRCPath FMedSci
Dr Nicholas Bown
et al.
Somatic mutation of genes impacting on the RAS-RAF-MEK-ERK pathway is the most common genetic abnormality in childhood acute lymphoblastic leukaemia, is implicated in disease progression and provides a rationale for therapeutic targeting2008
Dr Lisa Russell
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)2008
Marian Case
Dr Tina Davies
Professor Anthony Moorman
Emeritus Professor Andy Hall
Professor Julie Irving
et al.
The complex genomic profile of ETV6-RUNX1 positive acute lymphoblastic leukemia highlights a recurrent deletion of TBL1XR12008
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
The Spectrum and Prognostic Relevance of Additional Abnormalities, Involving 12p and 21q, in Children with ETV6-RUNX1 Positive Acute Lymphoblastic Leukaemia (ALL)2008
Elizabeth Matheson
Professor Anthony Moorman
Emeritus Professor Andy Hall
Professor Christine Harrison FRCPath FMedSci
Professor Julie Irving
et al.
Variable breakpoints target PAX5 in patients with dicentric chromosomes: A model for the basis of unbalanced translocations in cancer2008
Professor Christine Harrison FRCPath FMedSci
A de novo (1;2;3;15;18) chromosome rearrangement with six non reciprocal translocations.2007
Professor Christine Harrison FRCPath FMedSci
Dr Fiona Moorman
A multicenter evaluation of comprehensive analysis of MLL translocations and fusion gene partners in acute leukemia using the MLL FusionChip device2007
Professor Christine Harrison FRCPath FMedSci
Advances in molecular cytogenetics to study the leukaemia genome.2007
Dr Lisa Russell
Professor Christine Harrison FRCPath FMedSci
Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)2007
Dr Frederik van Delft
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Genome complexity in acute lymphoblastic leukemia is revealed by array-based comparative genomic hybridization2007
Professor Anthony Moorman
Marian Case
Professor Julie Irving
Emeritus Professor Andy Hall
Professor Christine Harrison FRCPath FMedSci
et al.
Genomic profiling reveals multiple genetic targets in ETV6-RUNX1 positive acute lymphoblastic leukaemia (ALL)2007
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Intrachromosomal amplification of chromosome 21 (iAMP21) arises from a breakage-fusion-bridge cycle2007
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Karyotype is an independent prognostic factor in adult acute lymphoblastic leukaemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 Trial2007
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Molecular cytogenetic characterisation of TCF3 (E2A)/19p13 rearrangements in acute lymphoblastic leukaemia2007
Professor Christine Harrison FRCPath FMedSci
Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: An international retrospective study2007
Professor Christine Harrison FRCPath FMedSci
Outcome of treatment in children with hypodiploid acute lymphoblastic leukemia2007
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)2007
Adillah Binti Yusof
Professor Julie Irving
Marian Case
Lynne Minto
Professor Christine Harrison FRCPath FMedSci
et al.
Red blood cell alloimmunization is affected by depletion of donor white cell subsets2007
Elizabeth Matheson
Lynne Minto
Professor Anthony Moorman
Emeritus Professor Andy Hall
Professor Julie Irving
et al.
Variable Breakpoints Target PAX5 in Patients with Dicentric Chromosomes: A Model for the Basis of Unbalanced Translocations in Cancer2007
Professor Christine Harrison FRCPath FMedSci
A diminutive chromosome 21 centromere in acute lymphoblastic leukemia2006
Emeritus Professor Andy Hall
Sarina Sulong
Professor Christine Harrison FRCPath FMedSci
Lynne Minto
Dr Nicholas Bown
et al.
Assessment of aneuploidy in childhood acute lymphoblastic leukaemia using high density oligonucleotide arrays.2006
Dr Frederik van Delft
Professor Christine Harrison FRCPath FMedSci
Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 212006
Sarina Sulong
Professor Julie Irving
Marian Case
Lynne Minto
Dr Nicholas Bown
et al.
Comprehensive analysis of p16(INK4a) in childhood acute lymphoblastic leukemia reveals homozygous deletion, haploinsufficiency and acquired isodisomy at the 9p locus with intact p16(INK4a).2006
Professor Christine Harrison FRCPath FMedSci
Deletion of chromosome 13 detected by conventional cytogenetics is a critical prognostic factor in myeloma2006
Professor Julie Irving
Lynne Minto
Elizabeth Matheson
Marian Case
Professor Simon Bailey
et al.
Mutation in genes impacting on the RAS-RAF-MEK-ERK pathway are found at high incidence in childhood acute lymphoblastic leukemia at both diagnosis and at relapse.2006
Dr Lisa Russell
Professor Christine Harrison FRCPath FMedSci
Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia2006
Professor Anthony Moorman
Dr Nicholas Bown
Professor Christine Harrison FRCPath FMedSci
PAX5-ETV6 fusion in acute lymphoblastic leukaemia des not define the dic(9;12)2006
Professor Christine Harrison FRCPath FMedSci
The Eighth International Childhood Acute Lymphoblastic Leukemia Workshop ('Ponte di legno meeting') report: Vienna, Austria, April 27-28, 20052006
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
ETV6/RUNX1 fusion at diagnosis and relapse: some prognostic indications2005
Professor Christine Harrison FRCPath FMedSci
Age has a profound effect on the incidence and significance of chromosome abnormalities in myeloma2005
Dr Paul Sinclair
Professor Christine Harrison FRCPath FMedSci
Analysis of balanced rearrangements of chromosome 6 in acute leukemia: clustered breakpoints in q22-q23 and possible involvement of c-MYB in a new recurrent translocation, t(6;7)(q23;q32 through 36)2005
Professor Christine Harrison FRCPath FMedSci
Cytogenetics of leukaemia and lymphoma2005
Professor Christine Harrison FRCPath FMedSci
Del (9q) AML: clinical and cytological characteristics and prognostic implications2005
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Derivative chromosome 9 deletions are a significant feature of childhood Philadelphia chromosome positive acute lymphoblastic leukaemia2005
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group Study2005
Professor Christine Harrison FRCPath FMedSci
Karyotyping lymph node biopsies in non-Hodgkin's lymphoma2005
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities2005
Professor Christine Harrison FRCPath FMedSci
Treatment strategy and long-term results in paediatric patients treated in consecutive UK AML trials2005
Dr Paul Sinclair
Professor Christine Harrison FRCPath FMedSci
A fluorescence in situ hybridization map of 6q deletions in acute lymphocytic leukemia: identification and analysis of a candidate tumor suppressor gene2004
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Amplification of the ABL gene in T-cell acute lymphoblastic leukemia2004
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Comparative expressed sequence hybridization studies of high-hyperdiploid childhood acute lymphoblastic leukemia2004
Professor Christine Harrison FRCPath FMedSci
Complex chromosomal abnormalities in utero, 5 years before leukaemia2004
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Is trisomy 5 a distinct cytogenetic subgroup in acute lymphoblastic leukemia?2004
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
MLL translocations with concurrent 3' deletions: interpretation of FISH results2004
Professor Christine Harrison FRCPath FMedSci
Molecular cytogenetics in childhood leukaemia2004
Professor Christine Harrison FRCPath FMedSci
MRC trials in childhood acute myeloid leukaemia2004
Professor Christine Harrison FRCPath FMedSci
Secondary cytogenetic aberrations in childhood Philadelphia chromosome positive acute lymphoblastic leukemia are nonrandom and may be associated with outcome2004
Professor Christine Harrison FRCPath FMedSci
Successful treatment without cranial radiotherapy of children receiving intensified chemotherapy for acute lymphoblastic leukaemia: results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI (ISRC TN 16757172)2004
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
t(14;19)(q32;q13): a recurrent translocation in B-cell precursor acute lymphoblastic leukemia2004
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia2004
Professor Christine Harrison FRCPath FMedSci
A unique variant of ETV6/AML1 fusion in a child with acute lymphoblastic leukemia2003
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome2003
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases2003
Professor Christine Harrison FRCPath FMedSci
Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements2003
Professor Christine Harrison FRCPath FMedSci
Cytogenetics of multiple myeloma: interpretation of fluorescence in situ hybridization results2003
Professor Christine Harrison FRCPath FMedSci
Cytogenetics of multiple myeloma: interpretation of fluorescence in situ hybridization results2003
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Frequency of ETV6/AML1 fusion in adult acute lymphoblastic leukaemia - response to Cuneo et al.2003
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia2003
Professor Christine Harrison FRCPath FMedSci
Dr Michael Griffiths
Prenatal origin of hyperdiploid acute lymphoblastic leukemia in identical twins2003
Professor Christine Harrison FRCPath FMedSci
ETV6/AML1 fusion by FISH in adult acute lymphoblastic leukaemia.2002
Professor Christine Harrison FRCPath FMedSci
Clinical features, cytogenetics and outcome in acute lymphoblastic and myeloid leukaemia of infancy: report from the MRC Childhood Leukaemia working party2002
Professor Christine Harrison FRCPath FMedSci
Cytogenetics and molecular genetics of acute lymphoblastic leukemia2002
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Involvement of the MLL gene in T-lineage acute lymphoblastic leukaemia2002
Professor Christine Harrison FRCPath FMedSci
Translocations of 14q32 and deletions of 13q14 are common chromosomal abnormalities in systemic amyloidosis (AL)2002
Professor Christine Harrison FRCPath FMedSci
Treatment of infants with lymphoblastic leukaemia2002
Professor Christine Harrison FRCPath FMedSci
Treatment of infants with lymphoblastic leukaemia: results of the UK Infant Protocols 1987-19992002
Professor Christine Harrison FRCPath FMedSci
Acute Lymphoblastic Leukaemia2001
Professor Christine Harrison FRCPath FMedSci
Dr Tim Butler
Cross species color banding in ten cases of myeloid malignancies with complex karyotypes2001
Professor Christine Harrison FRCPath FMedSci
Determinants of outcome after intensified therapy of childhood lymphoblastic leukaemia: results from Medical Research Council United Kingdom acute lymphoblastic leukaemia XI protocol2001
Professor Christine Harrison FRCPath FMedSci
Heterogeneity of VH-JH gene rearrangement patterns: an insight into the biology of B cell precursor ALL2001
Professor Christine Harrison FRCPath FMedSci
Molecular tracking of leukemogenesis in a triplet pregnancy2001
Professor Christine Harrison FRCPath FMedSci
The detection and significance of chromosomal abnormalities in childhood acute lymphoblastic leukaemia2001
Professor Christine Harrison FRCPath FMedSci
The Leukaemia Research Fund/United Kingdom Cancer Cytogenetics Group Karyotype Database in acute lymphoblastic leukaemia: a valuable resource for patient management2001
Professor Christine Harrison FRCPath FMedSci
The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial2001
Professor Christine Harrison FRCPath FMedSci
Three further cases of t(8;14)(q11.2;q32) in acute lymphoblastic leukemia2001
Gavin Cuthbert
Professor Christine Harrison FRCPath FMedSci
Dr Michael Griffiths
Dr Nicholas Bown
MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study2000
Professor Christine Harrison FRCPath FMedSci
Analysis of ETV6/AML1 abnormalities in acute lymphoblastic leukaemia: incidence, alternative spliced forms and minimal residual disease value2000
Dr Paul Sinclair
Professor Christine Harrison FRCPath FMedSci
Deletion of 6q16-q21 in human lymphoid maligancies: a mapping and deletion analysis2000
Professor Anthony Moorman
Professor Christine Harrison FRCPath FMedSci
Monosomy 20 as a pointer to dicentric (9;20) in acute lymphoblastic leukaemia2000
Professor Christine Harrison FRCPath FMedSci
Multiplex fluorescence in situ hybridization and cross species color banding of a case of chronic myeloid leukemia in blastic crisis with a complex Philadelphia translocation2000
Andrew Walker
Professor Christine Harrison FRCPath FMedSci
Sequential FISH reveals an abnormal karyotype involving 14 chromosomes in a child with acute lymphoblastic leukemia2000
Professor Christine Harrison FRCPath FMedSci
t(7;12)(q36;p13), a new recurrent translocation involving ETV6 in infant leukemia2000
Professor Christine Harrison FRCPath FMedSci
The genetics of childhood acute lymphoblastic leukaemia2000
Professor Christine Harrison FRCPath FMedSci
The lymphomas and chronic lymphoproliferative disorders2000
Professor Christine Harrison FRCPath FMedSci
The management of patients with leukaemia: the role of cytogenetics in this molecular era2000
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Emeritus Professor Alan Craft
Dr Juliet Hale
Dr Jennifer Kernahan
et al.
The United Kingdom Childhood Cancer Study: objectives, materials and methods2000
Professor Christine Harrison FRCPath FMedSci
A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukaemia derived from the MRC AML 10 trial1999
Professor Christine Harrison FRCPath FMedSci
A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukaemia derived from the MRC AML 10 trial. United Kingdom Medical Research Council's Adult and Childhood Leukaemia Working Parties1999
Professor Christine Harrison FRCPath FMedSci
Abnormal cytogenetic clones in patients with aplastic anaemia: response to immunosuppressive therapy1999
Professor Christine Harrison FRCPath FMedSci
Fluorescence in situ hybridization analysis of masked (8;21)(q22;q22) translocations1999
Professor Christine Harrison FRCPath FMedSci
Fluorescence In Situ Hybridization Analysis of Masked (8;21)(q22;q22) Translocations1999
Professor Christine Harrison FRCPath FMedSci
Investigation of clonal involvement of myeloid cells in Philadelphia-positive and high hyperdiploid acute lymphoblastic leukemia1999
Professor Christine Harrison FRCPath FMedSci
Investigation of minimal residual disease in childhood and adult acute lymphoblastic leukaemia by molecular analysis1999
Professor Christine Harrison FRCPath FMedSci
Abnormalities of the ETV6 gene occur in the majority of patients with aberrations of the short arm of chromosome 12: a combined PCR and Southern blotting analysis1998
Professor Christine Harrison FRCPath FMedSci
Professor Anthony Moorman
Ten novel 11q23 chromosomal partner sites1998
Professor Christine Harrison FRCPath FMedSci
The importance of cytogenetics and associated molecular techniques in the management of patients with leukaemia1998
Professor Christine Harrison FRCPath FMedSci
The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial1998
Professor Christine Harrison FRCPath FMedSci
A chromosome 14q11/TCR alpha/delta specific yeast artificial chromosome improves the detection rate and characterization of chromosome abnormalities in T-lymphoproliferative disorders1997
Professor Christine Harrison FRCPath FMedSci
Analysis of chromosome 6 deletions in lymphoid malignancies provides evidence for a region of minimal deletion within a 2-megabase segment of 6q211997
Professor Christine Harrison FRCPath FMedSci
Autografting in Philadelphia (Ph)+ chronic myeloid leukaemia using cultured marrow: an update of a pilot study1997
Professor Christine Harrison FRCPath FMedSci
Evaluation of cytogenetic conversion to Ph- haemopoiesis in long-term bone marrow culture for patients with chronic myeloid leukaemia on conventional hydroxyurea therapy, on pulse high-dose hydroxyurea and on interferon-alpha1996
Professor Christine Harrison FRCPath FMedSci
An interstitial deletion in the rearranged T-cell receptor gamma chain locus in a case of T-cell acute lymphoblastic leukaemia1995
Professor Christine Harrison FRCPath FMedSci
Detection of CBFB/MYH11 transcripts in patients with inversion and other abnormalities of chromosome 16 at presentation and remission1995
Professor Christine Harrison FRCPath FMedSci
Dicentric (9;12) in acute lymphocytic leukemia and other hematological malignancies: report from a dic(9;12) study group1995
Professor Christine Harrison FRCPath FMedSci
Retinoblastoma in association with the chromosome breakage syndromes Fanconi's anaemia and Bloom's syndrome: clinical and cytogenetic findings1995
Professor Christine Harrison FRCPath FMedSci
Acute lymphoblastic leukemia following Hodgkins Disease is associated with a poor prognosis1994
Dr Mauro Santibanez Koref
Professor Christine Harrison FRCPath FMedSci
Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia1994
Professor Christine Harrison FRCPath FMedSci
The karyotype of Alligator mississippiensis, and chromosomal mapping of the ZFY/X homologue, Zfc1994
Professor Christine Harrison FRCPath FMedSci
Localization of the estrogen receptor locus (ESR) to chromosome 6q25.1 by FISH and a simple post-FISH banding technique1993
Professor Christine Harrison FRCPath FMedSci
Reply to letter to the editors: t(12;17)(p12-13;q11-q12) associated with biphenotypic leukaemia1993
Professor Christine Harrison FRCPath FMedSci
Residual Ph- cells in chronic myeloid leukemia: detection and usefulness1993
Professor Christine Harrison FRCPath FMedSci
Structural abnormalities of the X chromosome in non-Hodgkin's lymphoma1993
Professor Christine Harrison FRCPath FMedSci
Three cases of the myelodysplastic syndrome with pericentric inversion of chromosome 161993
Professor Christine Harrison FRCPath FMedSci
Prognostic significance of the balanced t(1;19) and unbalanced der(19)t(1;19) translocations in acute lymphoblastic leukemia1992
Professor Christine Harrison FRCPath FMedSci
The lymphomas and chronic lymphoproliferative disorders1992
Professor Christine Harrison FRCPath FMedSci
Alveolar rhabdomyosarcoma with del(13q14)1991
Professor Christine Harrison FRCPath FMedSci
Hyperfibrotic myelodysplasia1991
Professor Christine Harrison FRCPath FMedSci
Monocytoid B cell lymphoma1991
Professor Christine Harrison FRCPath FMedSci
Myelodysplasia presenting as autoimmune haemolytic anaemia1991
Professor Christine Harrison FRCPath FMedSci
Near haploid acute lymphoblastic leukemia: seven new cases and a review of the literature1991
Professor Christine Harrison FRCPath FMedSci
Functional studies of bone marrow haemopoietic and stromal cells in the myelodysplastic syndrome (MDS)1990
Professor Christine Harrison FRCPath FMedSci
T cell non-Hodgkin's lymphoma with uveitis, pancreatitis, digital gangrene and multiple chromosomal abnormalities1990
Professor Christine Harrison FRCPath FMedSci
The use of cultured bone marrow cells in autologous transplantation1990
Professor Christine Harrison FRCPath FMedSci
Acute monocytic leukaemia and t(2;6) (p21;q26) translocation1989
Professor Christine Harrison FRCPath FMedSci
Fine-structural aspects of bromodeoxyuridine incorporation in sister chromatid differentiation and replication banding1989
Professor Christine Harrison FRCPath FMedSci
The role of clinical cytogenetics in medicine: with special emphasis on oncology1988
Professor Christine Harrison FRCPath FMedSci
A cell line from Wilms' tumour with deletion in short arm of chromosome II1987
Professor Christine Harrison FRCPath FMedSci
A scanning electron microscopy study of double minutes from a human tumour cell line1987
Professor Christine Harrison FRCPath FMedSci
Expression of human CD antigens, including CD1 and CD25, by human x mouse interlineage leukaemia hybrids1987
Professor Christine Harrison FRCPath FMedSci
The growth of myelodysplastic bone marrow in long-term cultures1987
Professor Christine Harrison FRCPath FMedSci
A structural basis for R- and T-banding: a scanning electron microscopy study1986
Professor Christine Harrison FRCPath FMedSci
Marrow-Cells from a Significant Proportion of Patients with Acute Myelogenous Leukemia Can Establish Normal Hematopoiesis When Grown in Long-Term Bone-Marrow Culture (LTBMC)1986
Professor Christine Harrison FRCPath FMedSci
Philadelphia-positive metaphases in the marrow after bone marrow transplantation for chronic granulocytic leukemia1986
Professor Christine Harrison FRCPath FMedSci
Reconstitution of haemopoietic system with autologous marrow taken during relapse of acute myeloblastic leukaemia and grown in long-term culture1986
Professor Christine Harrison FRCPath FMedSci
Scanning electron microscopy of human metaphase chromosomes1986
Professor Christine Harrison FRCPath FMedSci
Extramedullary transformation of chronic myeloid leukaemia with a unique chromosome pattern1985
Professor Christine Harrison FRCPath FMedSci
Investigation of human chromosome polymorphisms by scanning electron microscopy1985
Professor Christine Harrison FRCPath FMedSci
Light and scanning electron microscopy of the same human metaphase chromosomes1985
Professor Christine Harrison FRCPath FMedSci
The lymphomas and chronic lymphoproliferative disorders1985
Professor Christine Harrison FRCPath FMedSci
The structural basis for C-banding1985
Professor Christine Harrison FRCPath FMedSci
Chromosomal evidence of a common stem cell in acute lymphoblastic leukemia and chronic granulocytic leukemia1984
Professor Christine Harrison FRCPath FMedSci
Influence of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the susceptibility of K562 to natural cytotoxicity: evidence for clonal variation in differentiation-induced changes of lytic sensitivity1984
Professor Christine Harrison FRCPath FMedSci
Lumen formation in the developing mouse mammary gland1983
Professor Christine Harrison FRCPath FMedSci
Scanning electron microscopy of variations in human metaphase chromosome structure revealed by Giemsa banding1983
Professor Christine Harrison FRCPath FMedSci
The fragile X: a scanning electron microscope study1983
Professor Christine Harrison FRCPath FMedSci
High-resolution scanning electron microscopy of human metaphase chromosomes1982
Professor Christine Harrison FRCPath FMedSci
Scanning electron microscopy of the G-banded human karyotype1981
Professor Christine Harrison FRCPath FMedSci
Cell migration through three-dimensional gels of native collagen fibres: collagenolytic activity is not required for the migration of two permanent cell lines1980
Professor Christine Harrison FRCPath FMedSci
Changes in surface morphology associated with ageing and carcinogen treatment of Chinese hamster lung cells1980
Professor Christine Harrison FRCPath FMedSci
Cell surface morphology after trypsinisation depends on initial cell shape1979