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B-cell depletion with rituximab: a promising treatment for diffuse cutaneous systemic sclerosis

Lookup NU author(s): Professor Jaap Van Laar


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Recent preclinical and clinical studies lend support to the notion that B-cell depletion is a promising therapeutic target in patients with diffuse cutaneous systemic sclerosis. A recent open-label trial provides further evidence showing marked effects of rituximab treatment on skin thickening, functional ability, and disease activity in conjunction with effects on lesional and circulating B cells and on interleukin-6 and BAFF (B-cell activating factor of tumor necrosis factor family). The excellent safety profile of rituximab in this and other trials warrants further well-designed clinical trials in larger patient groups combined with comprehensive biomarker studies.

Publication metadata

Author(s): van Laar JM

Publication type: Editorial

Publication status: Published

Journal: Arthritis Research & Therapy

Year: 2010

Volume: 12

Issue: 2

Pages: -

Print publication date: 01/01/2010

ISSN (print): 1478-6354

ISSN (electronic): 1478-6362

Publisher: BioMed Central Ltd.