Publications by Professor Jaap Van Laar - ePrints

Browsing publications by Professor Jaap Van Laar.

Newcastle Authors	Title	Year
Gill Wheater Dr Mohsen Elshahaly Dr Stephen Tuck Dr Harish Datta Professor Jaap Van Laar et al.	Changes in bone density and bone turnover in patients with rheumatoid arthritis treated with rituximab, results from an exploratory, prospective study	2018
Sadaf Atarod Jean Norden Louis Bibby Dr Clare Lendrem Dr Kim Pearce et al.	Differential MicroRNA Expression Levels in Cutaneous Acute Graft-versus-Host Disease	2018
Professor Jaap Van Laar	Evolution of serum cytokine profile after hematopoietic stem cell transplantation in systemic sclerosis patients	2016
Professor Jaap Van Laar	Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis	2014
Dr Marzena Ciechomska Dr Steven O'Reilly Monika Suwara Professor Jaap Van Laar	MiR-29a Reduces TIMP-1 Production by Dermal Fibroblasts via Targeting TGF- β Activated Kinase 1 Binding Protein 1, Implications for Systemic Sclerosis	2014
Professor Jaap Van Laar	Multicriteria decision analysis methods with 1000Minds for developing systemic sclerosis classification criteria	2014
Dr Steven O'Reilly Rachel Cant Dr Marzena Ciechomska James Finnigan Professor Fiona Oakley et al.	Serum amyloid A induces interleukin-6 in dermal fibroblasts via Toll-like receptor 2, interleukin-1 receptor-associated kinase 4 and nuclear factor-kappa B	2014
Gill Wheater Dr Mohsen Elshahaly Dr Stephen Tuck Dr John Drury Professor Jaap Van Laar et al.	Bone marker reference range study: a comparison of the manufacturer’s reference range and laboratory healthy volunteer results to patients with rheumatoid arthritis	2013
Dr Mohsen Elshahaly Gill Wheater Dr Stephen Tuck Dr Harish Datta Professor Fai Ng et al.	Changes in bone density and bone turnover in patients with rheumatoid arthritis treated with rituximab, a B cell depleting monoclonal antibody (HORUS TRIAL)	2013
Professor Jaap Van Laar	Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study	2013
Dr Steven O'Reilly Rachel Cant Dr Marzena Ciechomska Professor Jaap Van Laar	Interleukin-6: a new therapeutic target in systemic sclerosis?	2013
Dr Marzena Ciechomska Rachel Cant James Finnigan Professor Jaap Van Laar Dr Steven O'Reilly et al.	Role of toll-like receptors in systemic sclerosis	2013
Professor Jaap Van Laar	Strontium ranelate: ready for clinical use as disease-modifying osteoarthritis drug?	2013
Gill Wheater Dr Mohsen Elshahaly Dr Stephen Tuck Dr Harish Datta Professor Jaap Van Laar et al.	The clinical utility of bone marker measurements in osteoporosis	2013
Dr Nicola Fullard Dr Steven O'Reilly Professor Jaap Van Laar David Faini Julie Diboll et al.	The c-Rel Subunit of NF-κB Regulates Epidermal Homeostasis and Promotes Skin Fibrosis in Mice	2013
Professor Jaap Van Laar	The Systemic Lupus Erythematosus IRF5 Risk Haplotype Is Associated with Systemic Sclerosis	2013
Dr Marzena Ciechomska Christiaan Huigens Tess Stanly Dr Andreas Gessner Professor Sophie Hambleton et al.	Toll-like receptor-mediated, enhanced production of profibrotic TIMP-1 in monocytes from patients with systemic sclerosis: role of serum factors	2013
Dr Thomas Huegle Dr Steven O'Reilly Rachel Simpson Dr Venetia Bigley Professor Matthew Collin et al.	Tumor Necrosis Factor-Costimulated T Lymphocytes From Patients With Systemic Sclerosis Trigger Collagen Production in Fibroblasts	2013
Professor Jaap Van Laar	KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor	2012
Professor Jaap Van Laar	A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations	2012
Professor Jaap Van Laar	A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis	2012
Professor Jaap Van Laar	A multicentre study confirms CD226 gene association with SSc-related pulmonary fibrosis	2012
Dr Marzena Ciechomska Christiaan Huigens Dr Andreas Gessner Dr Steven O'Reilly Professor Jaap Van Laar et al.	A novel role of monocytes in the induction of profibrotic tissue-inhibitor of metalloproteinase-1 mediated by toll-like receptors stimulation in SSC	2012
Professor Jaap Van Laar	Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Disease-Is It Now Ready for Prime Time?	2012
Dr Thomas Huegle Dr Kathryn White Professor Jaap Van Laar	Cell-to-cell contact of activated mast cells with fibroblasts and lymphocytes in systemic sclerosis	2012
Nadine Binai Dr Steven O'Reilly Dr Bridget Griffiths Professor Jaap Van Laar	Differentiation Potential of CD14(+) Monocytes into Myofibroblasts in Patients with Systemic Sclerosis	2012
Professor Jaap Van Laar	Direct vesicle transmission by mast cells to fibroblasts and lymphocytes in SSc	2012
Professor Jaap Van Laar	Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation	2012
Professor Jaap Van Laar	Haemopoietic stem-cell transplantation for systemic sclerosis	2012
Professor Jaap Van Laar	High Dose Immunoablation and Autologous Hematopoietic Stem Cell Transplantation Versus Monthly Intravenous Pulse Therapy Cyclophosphamide in Severe Systemic Sclerosis	2012
Professor Jaap Van Laar	Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up	2012
Dr Vanessa Hogan Philip Stocks Professor Jaap Van Laar	Induction of long-term B-cell depletion in refractory rheumatoid arthritis patients preferentially affects autoreactive more than protective humoral immunity	2012
Professor Jaap Van Laar	Influence of the IL6 Gene in Susceptibility to Systemic Sclerosis	2012
Dr Steven O'Reilly Dr Marzena Ciechomska Professor Jaap Van Laar	Interleukin-6, its role in fibrosing conditions	2012
Dr Vanessa Hogan Professor Jaap Van Laar	Pretreatment synovial transcriptional pro le is associated with early and late clinical response in rheumatoid arthritis patients treated with rituximab	2012
Dr Arthur Pratt Professor Jaap Van Laar	Rheumatoid arthritis: Pathogenesis and clinical aspects	2012
Dr Steven O'Reilly Dr Bridget Griffiths Dr Anja Krippner-Heidenreich Professor Jaap Van Laar	T cell derived IL-6 and IL-13 drive fibroblast fibrosis: Implications for systemic sclerosis	2012
Dr Steven O'Reilly Professor Jaap Van Laar	T cells in systemic sclerosis: a reappraisal	2012
Professor Jaap Van Laar	The autoimmune disease-associated IL2RA locus is involved in the clinical manifestations of systemic sclerosis	2012
Dr Mohsen Elshahaly Gill Wheater Dr Stephen Tuck Dr Harish Datta Professor Jaap Van Laar et al.	The role of B cells in bone turnover in rheumatoid arthritis	2012
Dr Marzena Ciechomska Dr Andreas Gessner Dr Steven O'Reilly Professor Jaap Van Laar	Toll-like receptor-mediated expression of profibrotic tissue-inhibitor of metalloproteinase-1 by circulating monocytes in Systemic sclerosis	2012
Professor Jaap Van Laar	A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort	2011
Dr Rajan Madhok Professor Jaap Van Laar	Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis	2011
Dr Vanessa Hogan Professor Jaap Van Laar	Changes in gene expression in synovial tissue from refractory rheumatoid arthritis patients treated with rituximab	2011
Dr Vanessa Hogan Professor Jaap Van Laar	Changes in gene expression in synovial tissue from refractory rheumatoid arthritis patients treated with rituximab	2011
Professor Jaap Van Laar	Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population	2011
Dr Andrew Russell Professor Jaap Van Laar	Determination of smoking status of rheumatoid arthritis patients by means of a self-reported questionnaire and serum cotinine assay: a cross-sectional study	2011
Professor Jaap Van Laar	EUSTAR biobanking: recommendations for the collection, storage and distribution of biospecimens in scleroderma research	2011
Professor Jaap Van Laar	Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy	2011
Professor Jaap Van Laar	Involvement of functional autoantibodies against vascular receptors in systemic sclerosis	2011
Professor Jaap Van Laar	Is there a role for TNF-alpha antagonists in the treatment of SSc? EUSTAR expert consensus development using the Delphi technique	2011
Dr Thomas Huegle Professor Jaap Van Laar	Late onset systematic sclerosis: A systematic survey of the eular scleroderma trials and research group database	2011
Dr Thomas Huegle Professor Jaap Van Laar	Late-onset systemic sclerosis-a systematic survey of the EULAR scleroderma trials and research group database	2011
Dr Thomas Huegle Dr Vanessa Hogan Dr Kathryn White Professor Jaap Van Laar	Mast Cells Are a Source of Transforming Growth Factor β in Systemic Sclerosis	2011
Professor Jaap Van Laar	Needs and preferences regarding health care delivery as perceived by patients with systemic sclerosis	2011
Dr Vanessa Hogan Professor Jaap Van Laar	Pretreatment Synovial Transcriptional Profile Predicts Early and Late Clinical Response in Rheumatoid Arthritis Patients Treated with Rituximab	2011
Professor Jaap Van Laar	Randomized Comparison of a Multidisciplinary Team Care Program With Usual Care in Patients With Systemic Sclerosis	2011
Nadine Binai Dr Thomas Huegle Professor Jaap Van Laar	Role of ET-1 and GM-CSF on the differentiation potential of monocytes in systematic sclerosis	2011
Nadine Binai Dr Thomas Huegle Professor Jaap Van Laar	Role of ET-1 and GM-CSF on the differentiation potential of monocytes in systemic sclerosis	2011
Gill Wheater Dr Vanessa Hogan Emeritus Professor Roger Francis Dr Stephen Tuck Dr Harish Datta et al.	Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis	2011
Gill Wheater Dr Vanessa Hogan Emeritus Professor Roger Francis Dr Harish Datta Professor Jaap Van Laar et al.	Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis	2011
Gill Wheater Dr Vanessa Hogan Emeritus Professor Roger Francis Dr Harish Datta Professor Jaap Van Laar et al.	Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis	2011
Dr Steven O'Reilly Dr Thomas Huegle Dr Anja Krippner-Heidenreich Professor Jaap Van Laar	T cell-derived IL-6 and IL-13 drive dermal fibrosis: implications for systemic sclerosis	2011
Dr Andreas Gessner Tess Stanly Dr Thomas Huegle Professor Jaap Van Laar	TIMP-1 production by monocytes may contribute to SSC skin fibrosis	2011
Dr Thomas Huegle Dr Anja Krippner-Heidenreich Rachel Simpson Dr Steven O'Reilly Dr Venetia Bigley et al.	Tumour necrosis factor alpha receptor activated T cells of patients with systemic sclerosis are deficient in IL-10 expression but promote myofibroblast differentiation via IL-6 and TGF-beta	2011
Dr Thomas Huegle Professor Jaap Van Laar	Allogeneic stem cell transplantation for rheumatic autoimmune diseases	2010
Dr Thomas Huegle Dr Venetia Bigley Professor Jaap Van Laar	Analysis of mononuclear cell subsets in dermis and blood of patients with systemic sclerosis by multicolour flow cytometry	2010
Professor Jaap Van Laar	B-cell depletion with rituximab: a promising treatment for diffuse cutaneous systemic sclerosis	2010
Professor Jaap Van Laar	Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database	2010
Professor Jaap Van Laar	Clinical response, pharmacokinetics, development of human anti-chimeric antibodies, and synovial tissue response to rituximab treatment in patients with rheumatoid arthritis	2010
Professor Jaap Van Laar	Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus	2010
Professor Jaap Van Laar	Immunesuppression in systematic sclerosis: Past, present and future	2010
Professor Jaap Van Laar	Intranasal administration of recombinant Human Cartilage glycoprotein-39 as a treatment for rheumatoid arthritis: A Phase II, multicenter, double-blind, randomized, placebo-controlled, parallel group dose-finding trial	2010
Professor Jaap Van Laar	Panel Session Report: Systemic Lupus Erythematosus	2010
Professor Jaap Van Laar	Panel Session Report: Systemic Sclerosis	2010
Professor Jaap Van Laar	Reply	2010
Professor Jaap Van Laar	Sexual function in women with systemic sclerosis: comment on the article by Schouffoer et al [reply]	2010
Professor Jaap Van Laar	Stem cells in the treatment of inflammatory arthritis	2010
Gill Wheater Dr Vanessa Hogan Emeritus Professor Roger Francis Dr Harish Datta Professor Jaap Van Laar et al.	Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis (Premier Poster-Award Candidate)	2010
Dr Thomas Huegle Professor Jaap Van Laar	Allogeneic hematopoietic SCT for patients with autoimmune diseases	2009
Professor Jaap Van Laar	ASTIS Trail	2009
Professor Jaap Van Laar	Autologous hematopoietic stem cell transplantation (HSCT) for autoimmune diseases: an observational study on 12 years of experience from the European Group for Blood and Marrow Transplantation (EBMT) Working Party on Autoimmune Diseases	2009
Professor Jaap Van Laar	Cytokine measurement before and after hematopoietic stem cell transplantation in severe diffuse systemic sclerosis	2009
Professor Jaap Van Laar	Heart failure as presenting manifestation of cardiac involvement in systemic lupus erythematosus	2009
Professor Jaap Van Laar	Impaired Sexual Function in Women With Systemic Sclerosis: A Cross-Sectional Study	2009
Arie Huigens Professor Jaap Van Laar	New pathogenic and therapeutic concepts in systemic sclerosis	2009
Professor Jaap Van Laar	Residual inflammation after rituximab treatment is associated with sustained synovial plasma cell infiltration and enhanced B cell repopulation	2009
Professor Jaap Van Laar	Rituximab fixed retreatment versus on-demand retreatment in refractory rheumatoid arthritis: comparison of two B cell depleting treatment strategies	2009
Professor Jaap Van Laar	Systemic sclerosis and its pulmonary complications in the Netherlands: an epidemiological study.	2009
Professor Jaap Van Laar	The clinical relevance of a repeat biopsy in lupus nephritis flares	2009
Dr Thomas Huegle Arie Huigens Dr Lesley Ottewell Dr Bridget Griffiths Professor Jaap Van Laar et al.	The role of fibrocytes in systemic sclerosis [Poster session]	2009
Professor Jaap Van Laar	The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype	2009
Alistair Brown Professor Jaap Van Laar Professor John Isaacs	Abnormal T cell differentiation persists in patients with rheumatoid arthritis in clinical remission and predicts relapse.	2008
Professor Jaap Van Laar	Arthroscopic lavage plus corticosteroids is more effective than joint aspiration plus corticosteroids in patients with arthritis of the knee	2008
Professor Jaap Van Laar	Autologous stem cell transplantation for severe systemic sclerosis: Update on the ASTIS-trial	2008
Professor Jaap Van Laar	Autologous stem cell transplantation for systemic sclerosis	2008
Professor Jaap Van Laar	CD20 epitope masking by rituximab: comment on the article by Gunnarsson et al	2008
Professor Jaap Van Laar	Cellular therapy of systemic sclerosis	2008
Professor Jaap Van Laar	Differences in synovial tissue infiltrates between anti-cyclic citrullinated peptide-positive rheumatoid arthritis and anti-cyclic citrullinated peptide-negative rheumatoid arthritis	2008
Professor Jaap Van Laar	Long-term follow-up results after autologous haematopoietic stem cell transplantation for severe systemic sclerosis.	2008
Professor Jaap Van Laar	Rituximab fixed retreatment versus on-demand retreatment in refractory rheumatoid arthritis: Comparison of two B-cell depleting treatment strategies	2008
Dr Thomas Huegle Professor Jaap Van Laar	Stem cell transplantation for rheumatic autoimmune diseases	2008
Professor Jaap Van Laar	Stem cell transplantation: a treatment option for severe systemic sclerosis?	2008
Professor Jaap Van Laar	The ASTIS trial	2008
Professor Jaap Van Laar	The Milwaukee shoulder/knee syndrome	2008
Professor Jaap Van Laar	The role of B cells in systemic sclerosis	2008
Professor Jaap Van Laar	Anticyclic citrullinated peptide antibodies: The footprint of autoreactive plasma cells in synovium?	2007
Professor Jaap Van Laar	Cell therapy for autoimmune diseases	2007
Professor Jaap Van Laar	Differential responsiveness to immunoablative therapy in refractory rheumatoid arthritis is associated with level and avidity of anti-cyclic citrullinated protein autoantibodies: a case study	2007
Professor Jaap Van Laar	Do high levels of IgA rheumatoid factor indicate a poor response to treatment with TNF inhibitors in patients with RA?	2007
Mukhtar Hashemi Professor Jaap Van Laar	Immunohistochemical analysis as a means to predict responsiveness to rituximab treatment	2007
Professor Jaap Van Laar	Poor serological responses upon influenza vaccination in patients with rheumatoid arthritis treated with rituximab	2007
Professor Jaap Van Laar	Scleroderma lung: pathogenesis, evaluation and current therapy	2007
Professor Jaap Van Laar	Sustained Secretion of Immunoglobulin by Long-Lived Human Tonsil Plasma Cells	2007
Professor Jaap Van Laar	Targeting host B-cell immune responses by persistent donor NK-cell alloreactivity following nonmyeloablative allogeneic stem cell transplantation	2007
Professor Jaap Van Laar	Pulmonary fibrosis in a patient with rheumatoid arthritis treated with adalimumab.	2006
Professor Jaap Van Laar	Autologous Stem cell Transplantation International Scleroderma (ASTIS) trial: hope on the horizon for patients with severe systemic sclerosis	2005
Professor Jaap Van Laar	Control of systemic B cell–mediated autoimmune disease by nonmyeloablative conditioning and major histocompatibility complex–mismatched allogeneic bone marrow transplantation	2005
Professor Jaap Van Laar	Feasibility of allogeneic hematopoietic stem cell transplantation for autoimmune disease: position statement from a National Institute of Allergy and Infectious Diseases and narional Cancer Institute	2005
Professor Jaap Van Laar	Long-Term Followup of Health Status in Patients With Severe Rheumatoid Arthritis After High-Dose Chemotherapy Followed by Autologous Hematopoietic Stem Cell Transplantation	2005
Professor John Isaacs Professor Jaap Van Laar	Outcome of intensive immunosuppression and autologous stem cell transplantation in patients with severe rheumatoid arthritis is associated with the composition of synovial T cell infiltration	2005
Alistair Brown Dr Prakash Patel Professor Jaap Van Laar Professor John Isaacs	Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia	2004
Professor Jaap Van Laar Professor John Isaacs	Dysregulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis	2002
Professor Jaap Van Laar	High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation in Patients With Rheumatoid Arthritis Results of an Open Study to Assess Feasibility, Safety, and Efficacy	2001