ePrints

Increased sex chromosome expression and epigenetic abnormalities in spermatids from male mice with Y chromosome deletions.

Lookup NU author(s): Dr Louise Reynard

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

During male meiosis, the X and Y chromosomes are transcriptionally silenced, a process termed meiotic sex chromosome inactivation (MSCI). Recent studies have shown that the sex chromosomes remain substantially transcriptionally repressed after meiosis in round spermatids, but the mechanisms involved in this later repression are poorly understood. Mice with deletions of the Y chromosome long arm (MSYq-) have increased spermatid expression of multicopy X and Y genes, and so represent a model for studying post-meiotic sex chromosome repression. Here, we show that the increase in sex chromosome transcription in spermatids from MSYq- mice affects not only multicopy but also single-copy XY genes, as well as an X-linked reporter gene. This increase in transcription is accompanied by specific changes in the sex chromosome histone code, including almost complete loss of H4K8Ac and reduction of H3K9me3 and CBX1. Together, these data show that an MSYq gene regulates sex chromosome gene expression as well as chromatin remodelling in spermatids

Publication metadata

Author(s): Reynard LN, Turner JM

Publication type: Article

Publication status: Published

Journal: Journal of Cell Science

Year: 2009

Volume: 122

Issue: 22

Pages: 4239-4248

Print publication date: 01/11/2009

ISSN (print): 0021-9533

ISSN (electronic): 1477-9137

Publisher: The Company of Biologists

URL: http://dx.doi.org/10.1242/jcs.049916

DOI: 10.1242/jcs.049916

PubMed id: 19861498

Altmetrics

Share