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Browsing publications by Dr Louise Reynard.

Newcastle AuthorsTitleYearFull text
Saad Aldalaqan
Caroline Dalgliesh
Dr Sara Luzzi
Chile Siachisumo
Dr Louise Reynard
et al.
Cryptic splicing: common pathological mechanisms involved in male infertility and neuronal diseases2022
Dr Faye Cooles
Dr Jessica Tarn
Dr Dennis Lendrem
Najib Naamane
Alice Lin
et al.
Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming2022
Dr Richard Howey
Alex Clark
Najib Naamane
Dr Louise Reynard
Dr Arthur Pratt
et al.
A Bayesian network approach incorporating imputation of missing data enables exploratory analysis of complex causal biological relationships2021
Dr Matthew Barter
Dr Catherine Bui
Kat Cheung
Julia Falk
Dr Rodolfo Gomez
et al.
DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions2020
Kat Cheung
Dr Matthew Barter
Julia Falk
Dr Carole Proctor
Dr Louise Reynard
et al.
Histone ChIP-Seq identifies differential enhancer usage during chondrogenesis as critical for defining cell-type specificity2020
Alex Clark
Dr Amy Anderson
Dr Nishanthi Thalayasingam
Najib Naamane
Julie Diboll
et al.
Lymphocyte DNA methylation mediates genetic risk at shared immune-mediated disease loci2020
Sam Charlton
Kat Cheung
Yao Hao
Dr Jamie Soul
Dr Louise Reynard
et al.
microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs2020
Kat Cheung
Marjolein Burgers
Professor David Young
Dr Simon Cockell
Dr Louise Reynard
et al.
Correlation of Infinium HumanMethylation450K and MethylationEPIC BeadChip arrays in cartilage2019
Dr Sarah Rice
Kat Cheung
Dr Louise Reynard
Professor John Loughlin
Discovery and analysis of methylation quantitative trait loci (mQTLs) mapping to novel osteoarthritis genetic risk signals2019
Dr Colin Shepherd
Abi Reese
Dr Louise Reynard
Professor John Loughlin
Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP2019
Dr Sarah Rice
Kat Cheung
Dr Louise Reynard
Professor John Loughlin
Identification and analysis of novel methylation quantitative trait loci (mQTLs) in osteoarthritis2019
Dr Louise Reynard
Dr Matthew Barter
Osteoarthritis year in review 2019: genetics, genomics and epigenetics2019
Dr Sarah Rice
Maria Tselepi
Dr Tony Sorial
Guillaume Aubourg
Dr Colin Shepherd
et al.
Prioritization of PLEC and GRINA as osteoarthritis risk genes through the identification and characterization of novel methylation quantitative trait loci2019
Dr Nishanthi Thalayasingam
Andrew Skelton
Dr Amy Anderson
Alex Clark
Julie Diboll
et al.
CD4+ and B lymphocyte expression quantitative traits at rheumatoid arthritis risk loci in untreated early arthritis: implications for causal gene identification2018
Chris Macdonald
Dr Adrian Falconer
Dr Chun Chan
Dr David Wilkinson
Andrew Skelton
et al.
Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to MMP1 expression in human chondrocytes2018
Dr Colin Shepherd
Dr Dongxing Zhu
Andrew Skelton
Dr Louise Reynard
Professor John Loughlin
et al.
Functional characterization of the osteoarthritis genetic risk residing at ALDH1A2 identifies rs12915901 as a key target variant.2018
Dr Colin Shepherd
Dr Louise Reynard
Professor John Loughlin
Genotype at the MGP OA risk locus correlates with an expression quantitative trait locus operating on MGP in cartilage and with DNA methylation at a cluster of regulatory CpGs within ARHGDIB2018
Dr Sarah Rice
Guillaume Aubourg
Dr Tony Sorial
Dr David Almarza Gomez
Maria Tselepi
et al.
Identification of a novel, methylation-dependent, RUNX2 regulatory region associated with osteoarthritis risk2018
Dr Sarah Rice
Dr Tony Sorial
Guillaume Aubourg
Dr Colin Shepherd
Maria Tselepi
et al.
Identification of novel methylation quantitative trait loci (mqtls) and functional characterization using CRISPR/CAS9 and gene expression analysis prioritizes PLEC as an OA risk gene2018
Dr Madhushika Ratnayake
Maria Tselepi
Dr Louise Reynard
Professor John Loughlin
A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF52017
Dr Louise Reynard
Analysis of genetics and DNA methylation in osteoarthritis: What have we learnt about the disease?2017
Dr Sarah Rice
Guillaume Aubourg
Dr Tony Sorial
Professor David Deehan
Professor John Loughlin
et al.
Epigenetic and transcriptional effects operate on the SUPT3H and RUNX2 genes residing at the chromosome 6p21.1 osteoarthritis susceptibility locus and correlate with the association signal2017
Dr Colin Shepherd
Dr Dongxing Zhu
Andrew Skelton
Dr Louise Reynard
Professor John Loughlin
et al.
Functional characterisation of the osteoarthritis genetic risk locus that resides at the gene ALDH1A2, coding for the retinoic acid synthesis enzyme RALDH2, identifies rs4646636 and rs12915901 as key target SNPs2017
Dr Louise Reynard
Andrew Skelton
David Young
Professor John Loughlin
The first international workshop on the epigenetics of osteoarthritis2017
Dr Louise Reynard
Dr Amanda Villalvilla Garcia
Professor John Loughlin
Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis2017
Andrew Skelton
Dr Rodolfo Gomez
Professor John Loughlin
Dr Louise Reynard
Age-related DNA methylation changes in normal and osteoarthritis cartilage2016
Dr Tarana Singh Dang
Dr Joe Willet
Helen Griffin
Dr Graeme O'Boyle
Dr Mario Abinun
et al.
Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency2016
Maria Tselepi
Madhushika Ratnayake
Dr Louise Reynard
Professor John Loughlin
Differences in the response of mesenchymal stem cells from healthy donors and OA patients to exogenous GDF5 during chondrogenic differentiation2016
Dr Amanda Villalvilla Garcia
Dr Fiona Gee
Professor John Loughlin
Dr Louise Reynard
DNA methylation in the 20q13 OA susceptibility region marked by rs6094710 is associated with modulation of NCOA3 gene expression2016
Dr Tarana Singh Dang
Dr Joe Willet
Helen Griffin
Dr Graeme O'Boyle
Dr Mario Abinun
et al.
Erratum to: Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency (vol 36, pg 117, 2016)2016
Dr Colin Shepherd
Andrew Skelton
Dr Michael Rushton
Dr Louise Reynard
Professor John Loughlin
et al.
Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs118428742016
Dr Louise Reynard
Dr Madhushika Ratnayake
Dr Mauro Santibanez Koref
Professor John Loughlin
Functional characterization of the osteoarthritis susceptibility mapping to CHST11 - a bioinformatics and molecular study2016
Emma Rogers
Dr Louise Reynard
Dr Kenneth Rankin
Professor John Loughlin
Functional Investigation of an OA susceptibility locus at chromsome 9q33.1 associated with female hip osteoarthritis2016
Dr Arthur Pratt
Dr Amy Anderson
Julie Diboll
Andrew Skelton
Dr Dennis Lendrem
et al.
Identification of novel expression quantitative trait loci in CD4+ T cells of untreated early arthritis patients2016
Dr Louise Reynard
Professor John Loughlin
Investigating the effects of high-glucose exposure on DNA methylation and gene transcription in musculoskeletal cells2016
Dr Fiona Gee
Dr Michael Rushton
Professor John Loughlin
Dr Louise Reynard
Correlation of the Osteoarthritis Susceptibility Variants That Map to Chromosome 20q13 With an Expression Quantitative Trait Locus Operating on NCOA3 and With Functional Variation at the Polymorphism rs1168553802015
Dr Michael Rushton
Professor David Young
Professor John Loughlin
Dr Louise Reynard
Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patients2015
Dr Michael Rushton
Professor David Young
Professor John Loughlin
Dr Louise Reynard
Differential DNA methylation and expression of inflammatory and zinc transporter genes defines sub-groups of osteoarthritic hip patients2015
Dr Colin Shepherd
Andrew Skelton
Dr Michael Rushton
Dr Louise Reynard
Professor John Loughlin
et al.
Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs118428742015
Dr Katherine Johnson
Dr Louise Reynard
Professor John Loughlin
Functional characterisation of the osteoarthritis susceptibility locus at chromosome 6q14.1 marked by the polymorphism rs93505912015
Dr Michael Rushton
Dr Louise Reynard
Professor David Young
Dr Colin Shepherd
Dr Rebecca Darlay
et al.
Methylation of cartilage DNA is a mediator of genetic risk at several OA susceptibility loci2015
Dr Michael Rushton
Dr Louise Reynard
Professor David Young
Dr Colin Shepherd
Dr Fiona Gee
et al.
Methylation quantitative trait locus (meQTL) analysis of osteoarthritis links epigenetics with genetic risk2015
Professor John Loughlin
Dr Louise Reynard
Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA2015
Professor John Loughlin
Dr Louise Reynard
Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA2015
Dr Louise Reynard
Professor John Loughlin
The carbohydrate sulfotransferase gene CHST11 is regulated by DNA methylation which impacts on the functional effect of the OA generic susceptibility residing at this locus2015
Emma Rogers
Dr Louise Reynard
Professor John Loughlin
The role of inflammation-related genes in osteoarthritis2015
Dr Fiona Gee
Clare Clubbs
Dr Emma Raine
Dr Louise Reynard
Professor John Loughlin
et al.
Allelic expression analysis of genes from within the osteoarthritis susceptibility locus at chromosome 3p21 reveals functional gene expression effects at GNL3 and SPCS1 that correlate with the association signal2014
Dr Fiona Gee
Clare Clubbs
Emma Raine
Dr Louise Reynard
Professor John Loughlin
et al.
Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS1 2014
Dr Fiona Gee
Clare Clubbs
Dr Emma Raine
Dr Louise Reynard
Professor John Loughlin
et al.
Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS12014
Dr Michael Rushton
Dr Louise Reynard
Dr Matthew Barter
Dr Kenneth Rankin
Professor David Young
et al.
Characterisation of the cartilage DNA methylome in knee and hip osteoarthritis using high-density genome-wide analysis2014
Dr Michael Rushton
Dr Louise Reynard
Dr Matthew Barter
Ramsay Refaie
Dr Kenneth Rankin
et al.
Characterization of the cartilage DNA methylome in knee and hip osteoarthritis2014
Dr Louise Reynard
Dr Catherine Bui
Catherine Syddall
Professor John Loughlin
CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs1433832014
Dr David McDonald
Dr Bernadette Carroll
Nicholas Robertson
Dr Helen Griffin
Professor Jeremy Lakey
et al.
Dual Proteolytic Pathways Govern Glycolysis and Immune Competence2014
Emma Rogers
Dr Louise Reynard
Dr Kate Rennie
Professor John Loughlin
Expression analysis of osteoarthritis associated genes in mesenchymal stem cells differentiating into joint-associated cells2014
Dr Katherine Johnson
Dr Louise Reynard
Professor John Loughlin
Functional analysis of the osteoarthritis susceptibility locus marked by the polymorphism rs104923672014
Dr Louise Reynard
Dr Madhushika Ratnayake
Dr Mauro Santibanez Koref
Professor John Loughlin
Functional analysis of the osteoarthritis susceptibility locus residing at the carbohydrate sulfotransferase 11 gene CHST112014
Emma Raine
Dr Louise Reynard
Professor John Loughlin
Identification and analysis of a SMAD3 cis-acting eQTL operating in primary osteoarthritis and in the aneurysms and osteoarthritis syndrome2014
Dr Emma Raine
Dr Louise Reynard
Professor John Loughlin
Identification and analysis of a SMAD3 cis-acting eQTL operating in primary osteoarthritis and in the aneurysms and osteoarthritis syndrome2014
Dr Michael Rushton
Dr Fiona Gee
Dr Louise Reynard
Professor John Loughlin
The osteoarthritis association marked by SNP rs6094710 mediates its effect by reducing the expression of NCOA3 in joint tissues2014
Dr Emma Raine
Andrew Dodd
Dr Louise Reynard
Professor John Loughlin
Allelic expression analysis of the osteoarthritis susceptibility gene COL11A1 in human joint tissues2013
Dr Louise Reynard
Professor John Loughlin
Insights from human genetic studies into the pathways involved in osteoarthritis2013
Dr Louise Reynard
Professor John Loughlin
The genetics and functional analysis of primary osteoarthritis susceptibility2013
Catherine Syddall
Dr Louise Reynard
Professor David Young
Professor John Loughlin
The Identification of Trans-acting Factors That Regulate the Expression of GDF5 via the Osteoarthritis Susceptibility SNP rs1433832013
Andrew Dodd
Dr Emma Raine
Dr Louise Reynard
Professor John Loughlin
Allelic expression analysis in patient issues of the osteoarthritis and of the lumbar disc herniation susceptibility loci that map to COL11A12012
Dr Madhushika Ratnayake
Dr Louise Reynard
Dr Emma Raine
Dr Mauro Santibanez Koref
Professor John Loughlin
et al.
Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL32012
Dr Madhushika Ratnayake
Dr Louise Reynard
Dr Emma Raine
Dr Mauro Santibanez Koref
Professor John Loughlin
et al.
Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL32012
Dr Madhushika Ratnayake
Dr Louise Reynard
Emma Raine
Dr Mauro Santibanez Koref
Professor John Loughlin
et al.
Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL32012
Dr Emma Raine
Dr Louise Reynard
Professor John Loughlin
Allelic expression analysis, and association with OA, of common variants in SMAD32012
Professor Sophie Hambleton
Dr David McDonald
Dr Helen Griffin
Angela Grainger
Dr Louise Reynard
et al.
Autosomal recessive combines immunodeficiency due to loss of function mutation in Tripeptidyl Peptidase II2012
Dr Catherine Bui
Dr Matthew Barter
Jenny Scott
Martin Galler
Dr Louise Reynard
et al.
cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis2012
Professor Matthew Collin
Dr Rachel Dickinson
Professor Muzlifah Haniffa
Dr Naomi McGovern
Dr Helen Griffin
et al.
Evolution of Dendritic Cell, Monocyte B and NK Lymphoid (DCML) deficiency; a human primary immunodeficiency arising from GATA-2 mutation2012
Dr Louise Reynard
Professor John Loughlin
Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q222012
Dr Emma Raine
Andrew Dodd
Dr Louise Reynard
Professor John Loughlin
Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q222012
Dr Louise Reynard
Professor John Loughlin
Genetics and epigenetics of osteoarthritis2012
Catherine Syddall
Dr Louise Reynard
Professor David Young
Professor John Loughlin
The identification of the trans-acting factors that differentially regulate the expression of GDF5 via the OA associated SNP rs1433832012
Catherine Syddall
Dr Louise Reynard
Professor David Young
Professor John Loughlin
The identification of trans-acting factors that differentially regulate the expression of GDF5 via the osteoarthritis associated SNP RS1433832012
Dr Louise Reynard
Catherine Syddall
Professor John Loughlin
The osteoarthritis susceptibility gene GDF5 is under epigenetic regulation by DNA methylation - the molecular interplay between genetics and epigenetics in disease risk2012
Dr Helen Griffin
Dr David McDonald
Dr Rachel Dickinson
Angela Grainger
Dr Louise Reynard
et al.
Whole exome sequencing as a diagnostic tool in primary immunodeficiency2012
Andrew Dodd
Dr Louise Reynard
Professor John Loughlin
Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus2011
Dr Rachel Dickinson
Dr Helen Griffin
Dr Venetia Bigley
Dr Louise Reynard
Raf Hussain
et al.
Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency2011
Dr Louise Reynard
Dr Catherine Bui
Professor David Young
Professor John Loughlin
Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation2011
Dr David McDonald
Dr Helen Griffin
Angela Grainger
Dr Louise Reynard
Professor John Loughlin
et al.
Whole-exome deep sequencing identifies a novel causative mutation in primary immunodeficiency2011
Dr Louise Reynard
Athanasia Gravani
Professor John Loughlin
The osteoarthritis-associated gene GDF5 is under epigenetic regulation in patient tissues and in a range of human cell lines2010
Dr Louise Reynard
Increased sex chromosome expression and epigenetic abnormalities in spermatids from male mice with Y chromosome deletions.2009
Dr Louise Reynard
The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein2009
Dr Louise Reynard
Expression analysis of the mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein, SLX/XMR2007