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Preempting and preventing drug-induced liver injury

Lookup NU author(s): Professor Ann DalyORCiD


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A new study reports that susceptibility to drug-induced liver injury by the cyclooxygenase 2 (COX-2) inhibitor lumiracoxib is associated with a human lymphocyte antigen (HLA) class II haplotype. This finding suggests that those at risk of hepatotoxicity can be identified by HLA genotyping, raising the possibility that lumiracoxib can be resurrected as a useful drug.

Publication metadata

Author(s): Aithal GP, Daly AK

Publication type: Editorial

Publication status: Published

Journal: Nature Genetics

Year: 2010

Volume: 42

Issue: 8

Pages: 650-651

Print publication date: 01/08/2010

ISSN (print): 1061-4036

ISSN (electronic): 1546-1718

Publisher: Nature Publishing Group


DOI: 10.1038/ng0810-650