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Lookup NU author(s): Professor John Sayer,
Dr Georgina Carr,
Dr Shabbir Moochhala,
Professor Nicholas Simmons
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Since the 1960's, inorganic pyrophosphate (PPi) has been known to inhibit apatite precipitation. Recent findings suggest that PPi plays a central role in the control of normal bone mineralization. Knockout mice have established the functional importance of PPi transmembrane transport, via the pyrophosphate transporter ANKH. The molecular nature and transport function of ANKH are reviewed. PPi is present in urine and ANKH is expressed in the cortical collecting duct where PPi transport to both the tubular lumen and renal interstitium may occur. Arginine vasopressin stimulation of cortical collecting duct cells grown on semipermeable supports appears to upregulate apical ANKH expression, which we postulate may be a mechanism of stone inhibition during urinary concentration and supersaturation of calcium salts. Hypopyrophosphaturia may be a forgotten metabolic risk factor for stone formation and polymorphisms of the ANKH gene may underlie this defect. The physiological importance and clinical significance of PPi generation and transport in preventing idiopathic renal stone disease and nephrocalcinosis now needs to be established. © 2008 American Institute of Physics.
Author(s): Sayer JA, Carr G, Moochhala SH, Simmons NL
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: AIP Conference Proceedings. Renal Stone Disease 2: 2nd International Urolithiasis Research Symposium
Year of Conference: 2008
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