Publications by Professor Nicholas Simmons - ePrints

Browsing publications by Professor Nicholas Simmons.

Newcastle Authors	Title	Year
Iain Haslam Professor Nicholas Simmons	Expression of the ABC transport proteins MDR1 (ABCB1) and BCRP (ABCG2) in bovine rumen	2014
Dr Ann Marie Hynes Dr Shalabh Srivastava Dr Lorraine Eley Dr Marina Danilenko Professor Peter Thelwall et al.	Murine Joubert syndrome reveals Hedgehog signaling defects as a potential therapeutic target for nephronophthisis	2014
Jamie Wright Professor Nicholas Simmons	Breast cancer resistance protein BCRP (ABCG2)-mediated transepithelial nitrofurantoin secretion and its regulation in human intestinal epithelial (Caco-2) layers	2011
Jamie Wright Professor Nicholas Simmons	Intestinal Ciprofloxacin Efflux: The Role of Breast Cancer Resistance Protein (ABCG2)	2011
Dr Georgina Carr Jamie Wright Professor Nicholas Simmons	Epithelial Barrier Resistance is Increased by the Divalent Cation Zinc in Cultured MDCKII Epithelial Monolayers	2010
John Linley Dr Stefan Boese Professor Nicholas Simmons Dr Michael Gray	A Voltage-Dependent Ca2+ Influx Pathway Regulates the Ca2+-Dependent Cl- Conductance of Renal IMCD-3 Cells	2009
Professor Nicholas Simmons Dr Abdul Chaudhry Dr Christopher Graham Dr Gavin Stewart	Dietary regulation of ruminal bovine UT-B urea transporter expression and localization	2009
Dr Georgina Carr Dr Shabbir Moochhala Dr Lorraine Eley Professor Nicholas Simmons Professor John Sayer et al.	The Pyrophosphate Transporter ANKH is Expressed in Kidney and Bone Cells and Colocalises to the Primary Cilium/Basal Body Complex	2009
Iain Haslam Professor Keith Jones Professor Nicholas Simmons	Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84)	2008
Professor John Sayer Dr Georgina Carr Dr Shabbir Moochhala Professor Nicholas Simmons	Pyrophosphate transport and stones	2008
Professor John Sayer Dr Georgina Carr Dr Shabbir Moochhala Professor Nicholas Simmons	Pyrophosphate Transport and Stones	2008
Iain Haslam Professor Nicholas Simmons	Rifampin and digoxin induction of MDR1 expression and function in human intestinal (T84) epithelial cells	2008
Dr Georgina Carr Professor John Sayer Professor Nicholas Simmons	Expression and localisation of the pyrophosphate transporter, ANK, in murine kidney cells	2007
Dr Christopher Graham Dr Ian Gatherar Iain Haslam Dr Michael Glanville Professor Nicholas Simmons et al.	Expression and localization of monocarboxylate transporters and sodium/proton exchangers in bovine rumen epithelium	2007
John Linley Professor Nicholas Simmons Dr Michael Gray	Extracellular zinc stimulates a calcium-activated chloride conductance through mobilisation of intracellular calcium in renal inner medullary collecting duct cells	2007
Dr Georgina Carr Professor Nicholas Simmons Professor John Sayer	Disruption of clc-5 leads to a redistribution of annexin A2 and promotes calcium crystal agglomeration in collecting duct epithelial cells	2006
Dr Georgina Carr Iain Haslam Professor Nicholas Simmons	Voltage dependence of transepithelial guanidine permeation across Caco-2 epithelia allows determination of the paracellular flux component	2006
Dr Christopher Graham Professor Nicholas Simmons	Characterization of a cDNA expressed in bovine rumen encoding a facilitative urea transporter	2005
Dr Christopher Graham Professor Nicholas Simmons	Functional organization of the bovine rumen epithelium	2005
Dr Christopher Graham Professor Nicholas Simmons	Functional organization of the bovine rumen epithelium	2005
Dr Gavin Stewart Dr Christopher Graham Professor Nicholas Simmons	UT-B is expressed in bovine rumen: Potential role in ruminal urea transport	2005
Dr Stefan Boese Dr Michael Gray Professor Nicholas Simmons	Volume-dependent and -independent activated anion conductances and their interaction in the renal inner medullary collecting duct (IMCD)	2005
Professor John Sayer Dr Georgina Carr Professor Nicholas Simmons	Calcium phosphate and calcium oxalate crystal handling is dependent upon CLC-5 expression in mouse collecting duct cells	2004
Dr Stefan Boese Omar Aziz Professor Nicholas Simmons Dr Michael Gray	Kinetics and regulation of a Ca²⁺-activated Cl^- conductance in mouse renal inner medullary collecting duct cells	2004
Professor Nicholas Simmons Emeritus Professor Barry Hirst	Comparison of poly(DL-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells	2003
Professor John Sayer Dr Georgina Carr Professor Simon Pearce Professor Tim Goodship Professor Nicholas Simmons et al.	Disordered calcium crystal handling in antisense CLC-5-treated collecting duct cells	2003
Professor Nicholas Simmons	Evidence for a non-MDR1 component in digoxin secretion by human intestinal Caco-2 epithelial layers	2003
Dr Michael Gray Omar Aziz Professor Nicholas Simmons Dr Stefan Boese	Intracellular Ca2+ directly regulates the Ca2+ activated Cl conductance in mouse inner medullary collecting duct cells	2003
Dr Stefan Boese Omar Aziz Professor Nicholas Simmons Dr Michael Gray	Intracellular Ca2+ directly regulates the Ca2+-activated Cl- conductance in mouse inner medullary collecting duct cells	2003
Dr Georgina Carr Professor John Sayer Professor Nicholas Simmons	Altered CLC-5 expression in mouse inner medullary collecting duct cells disrupts endocytosis and promotes calcium oxalate crystal adhesion	2002
Professor John Sayer Dr Georgina Carr Professor Nicholas Simmons Professor Tim Goodship	Antisense CLC-5 disrupts acidic endosomes and endocytosis in murine collecting duct cells	2002
Professor David Thwaites Professor David Kennedy Dr Demetrio Raldua Dr Catriona Anderson Dr Ma Mendoza-Gomez et al.	H⁺/dipeptide absorption across the human intestinal epithelium is controlled indirectly via a functional Na⁺/H⁺ exchanger	2002
Dr Simon Lowes Professor Nicholas Simmons	Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco-2) cells	2002
Dr Stefan Boese Professor John Sayer Dr Gavin Stewart Dr Michael Glanville Dr Michael Gray et al.	Renal expression of Ca2+-activated Cl- channels	2002
Dr Stefan Boese Professor John Sayer Dr Gavin Stewart Dr Michael Glanville Dr Michael Gray et al.	Renal expression of Ca2+-activated Cl- channels	2002
Professor John Sayer Professor Nicholas Simmons	Urinary stone formation: Dent's disease moves understanding forward	2002
Professor David Thwaites Professor Nicholas Simmons	Expression and role of sodium, potassium, chloride cotransport (NKCC1) in mouse inner medullary collecting duct (mIMCD-K2) epithelial cells	2001
Dr Simon Lowes Professor Nicholas Simmons	Human intestinal cell monolayers are preferentially sensitive to disruption of barrier function from basolateral exposure to cholic acid: Correlation with membrane transport and transepithelial secretion	2001
Dr Catriona Anderson Dr Demetrio Raldua Professor Nicholas Simmons Professor David Thwaites	pH-dependent forskolin modulation of beta-alanine uptake at the apical surface of Caco-2 cell monolayers	2001
Dr Gavin Stewart Omar Aziz Professor Nicholas Simmons Dr Michael Gray	Regulation of an outwardly rectifying chloride conductance in renal epithelial cells by external and internal calcium	2001
Professor John Sayer Dr Gavin Stewart Dr Stefan Boese Dr Michael Gray Professor Simon Pearce et al.	The voltage-dependent of Cl- channel ClC-5 and plasma membrane Cl- conductances of mouse renal collecting duct cells (mIMCD-3)	2001
Dr Michael Gray Dr Colin Brown Professor Nicholas Simmons	Bradykinin regulation of salt transport across mouse inner medullary collecting duct epithelium involves activation of a Ca2+ -dependent Cl- conductance	2000
Dr Stefan Boese Dr Michael Glanville Omar Aziz Dr Michael Gray Professor Nicholas Simmons et al.	Ca2+ and cAMP-activated Cl- conductances mediate Cl- secretion in a mouse renal inner medullary collecting duct cell line	2000
Professor David Thwaites Dr Laura Basterfield Professor Nicholas Simmons	Gamma-aminobutyric acid (GABA) transport across human intestinal epithelial (Caco-2) cell monolayers	2000
Dr Stefan Boese Dr Michael Glanville Dr Michael Gray Professor Nicholas Simmons	The swelling-activated anion conductance in the mouse renal inner medullary collecting duct cell line mIMCD-K2	2000
Dr Stefan Boese Professor Nicholas Simmons Dr Michael Gray	ATP and forskolin stimulate transepithelial Cl- secretion in mouse renal inner medullary collecting duct cells (mIMCD-K2) by activation of distinct Cl- conductances	1999
Dr Gavin Stewart Dr Michael Glanville Dr Michael Gray Professor Nicholas Simmons	ATP stimulates a chloride conductance in the mIMCD-3 cell line	1999
Professor David Thwaites Professor Dianne Ford Dr Michael Glanville Professor Nicholas Simmons	H⁺/solute-induced intracellular acidification leads to selective activation of apical Na⁺/H⁺ exchange in human intestinal epithelial cells	1999
Dr Stefan Boese Dr Michael Glanville Professor Nicholas Simmons Dr Michael Gray	The swelling-activated chloride conductance in mIMCD-K2 cells is associated with multiple CLC expression.	1999
Professor Dianne Ford Professor David Thwaites Professor Nicholas Simmons Emeritus Professor Harry Gilbert Emeritus Professor Barry Hirst et al.	Substrate upregulation of the human small intestinal peptide transporter, hPepT1	1998
Professor David Thwaites Professor Nicholas Simmons	Na⁺-independent lysine transport in human intestinal Caco-2 cells	1996
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	Angiotensin-converting enzyme (ACE) inhibitor transport in human intestinal epithelial (Caco-2) cells	1995
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	D-Cycloserine transport in human intestinal epithelial (Caco-2) cells is mediated by a H⁺-coupled amino acid transporter	1995
Professor David Thwaites Professor Nicholas Simmons	H⁺/di-tripeptide transporter (PepT1) expression in the rabbit intestine	1995
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	H⁺-coupled alpha-methylaminoisobutyric acid transport in human intestinal Caco-2 cells	1995
Professor David Thwaites Professor Nicholas Simmons	The role of the proton electrochemical gradient in the transepithelial absorption of amino acids by human intestinal Caco-2 cell monolayers	1995
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	H⁺-coupled solute transport in cultured intestinal epithelia	1994
Professor David Thwaites Dr Colin Brown Emeritus Professor Barry Hirst Professor Nicholas Simmons	L-Alanine absorption in human intestinal cells driven by the proton electrochemical gradient	1994
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	Substrate specificity of the di/tripeptide transporter in human intestinal epithelia (Caco-2): identification of substrates that undergo H⁺-coupled absorption	1994
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	Direct assessment of dipeptide/H⁺ symport in intact human intestinal (Caco-2) epithelium: a novel method utilising continuous intracellular pH measurement	1993
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	H⁺-coupled (Na⁺-independent) proline transport in human intestinal (Caco-2) epithelial cell monolayers	1993
Professor David Thwaites Dr Colin Brown Emeritus Professor Barry Hirst Professor Nicholas Simmons	H⁺-coupled dipeptide (glycylsarcosine) transport across apical and basal borders of human intestinal Caco-2 cell monolayers display distinctive characteristics	1993
Professor David Thwaites Dr Colin Brown Emeritus Professor Barry Hirst Professor Nicholas Simmons	Na⁺-independent, H⁺-coupled transepithelial beta-alanine absorption by human intestinal Caco-2 cell monolayers	1993
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	Passive transepithelial absorption of thyrotropin-releasing hormone (TRH) via a paracellular route in cultured intestinal and renal epithelial cell lines	1993
Professor David Thwaites Professor Nicholas Simmons Emeritus Professor Barry Hirst	Thyrotropin-releasing hormone (TRH) uptake in intestinal brush-border membrane vesicles: comparison with proton-coupled dipeptide and Na⁺-coupled glucose transport	1993
Professor David Thwaites Emeritus Professor Barry Hirst Professor Nicholas Simmons	Transepithelial dipeptide (glycylsarcosine) transport across epithelial monolayers of human Caco-2 cells is rheogenic	1993
Professor David Thwaites Dr Colin Brown Emeritus Professor Barry Hirst Professor Nicholas Simmons	Transepithelial glycylsarcosine transport in intestinal Caco-2 cells mediated by expression of H⁺-coupled carriers at both apical and basal membranes	1993