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Genes and nonalcoholic fatty liver disease

Lookup NU author(s): Dr Nimantha De Alwis, Professor Chris Day


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Whereas most individuals with nonalcoholic fatty liver disease (NAFLD) will have steatosis, only a minority will ever develop progressive disease. Family studies and interethnic variations in susceptibility suggest that genetic factors may be important in determining disease risk. Although no genetic associations with advanced NAFLD have been replicated in large studies, preliminary data suggest that polymorphisms in the genes encoding microsomal triglyceride transfer protein, superoxide dismutase 2, the CD14 endotoxin receptor, tumor necrosis factor-α, transforming growth factor-β, and angiotensinogen may be associated with steatohepatitis and/or fibrosis. With the advent of high-throughput gene analyses and the reduced cost of whole genome-wide scans, it seems likely that genes contributing to inherited susceptibility to this common disease will be identified in the near future. Copyright © 2008 by Current Medicine Group LLC.

Publication metadata

Author(s): de Alwis NMW, Day CP

Publication type: Review

Publication status: Published

Journal: Current Diabetes Reports

Year: 2008

Volume: 8

Issue: 2

Pages: 156-163

ISSN (print): 1534-4827

ISSN (electronic): 1539-0829


DOI: 10.1007/s11892-008-0027-9

PubMed id: 18445359