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Adult-onset, short-term dietary restriction reduces cell senescence in mice

Lookup NU author(s): Mandy Maddick, Dr Satomi Miwa, Dr Diana Jurk, Dr Rafal Czapiewski, Dr Gabriele Saretzki, Dr Sabine Langie, Dr Kerry Cameron, Professor Thomas von Zglinicki



Dietary restriction (DR) extends the lifespan of a wide variety of species and reduces the incidence of major age-related diseases. Cell senescence has been proposed as one causal mechanism for tissue and organism ageing. We show for the first time that adult-onset, short-term DR reduced frequencies of senescent cells in the small intestinal epithelium and liver of mice, which are tissues known to accumulate increased numbers of senescent cells with advancing age. This reduction was associated with improved telomere maintenance without increased telomerase activity. We also found a decrease in cumulative oxidative stress markers in the same compartments despite absence of significant changes in steady-state oxidative stress markers at the whole tissue level. The data suggest the possibility that reduction of cell senescence may be a primary consequence of DR which in turn may explain known effects of DR such as improved mitochondrial function and reduced production of reactive oxygen species.

Publication metadata

Author(s): Wang CF, Maddick M, Miwa S, Jurk D, Czapiewski R, Saretzki G, Langie SAS, Godschalk RWL, Cameron K, von Zglinicki T

Publication type: Article

Publication status: Published

Journal: Aging

Year: 2010

Volume: 2

Issue: 9

Pages: 555-566

Print publication date: 01/09/2010

Date deposited: 21/01/2011

ISSN (print):

ISSN (electronic): 1945-4589

Publisher: Impact Journals LLC