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Browsing publications by Dr Gabriele Saretzki.

Newcastle AuthorsTitleYearFull text
Dr Tengfei Wan
Mary Johnson
Dr Viktor Korolchuk
Dr Gabriele Saretzki
Increased telomerase improves motor function and alpha-synuclein pathology in a transgenic mouse model of Parkinson’s disease associated with enhanced autophagy2021
Dr Gabriele Saretzki
Endometriosis is associated with a significant increase in hTERC and altered telomere/telomerase associated genes in the eutopic endometrium; an ex-vivo and in silico study2020
Dr Gabriele Saretzki
Human endometrial carcinogenesis is associated with significant reduction in Long non-coding RNA, TERRA2020
Dr Carmen Martin-Ruiz
Dr Alison Yarnall
Dr John Boucher
Dr Rachael Lawson
Claire Kolenda
et al.
Senescence and inflammatory markers for predicting clinical progression in Parkinson's disease-the ICICLE-PD study2020
Dr Danny Chan
Dr Carmen Martin-Ruiz
Dr Gabriele Saretzki
Dr R Neely
Professor Vijay Kunadian
et al.
The association of telomere length and telomerase activity with adverse outcomes in older patients with non-ST-elevation acute coronary syndrome2020
Dr Gabriele Saretzki
The wonderful new world of telomerase in the brain and its possible implications for neurodegenerative diseases2020
Dr Mikolaj Ogrodnik
Dr Olena Kucheryavenko
Julien Glibert
Dr Satomi Miwa
Abbas Ishaq
et al.
The bystander effect contributes to the accumulation of senescent cells in vivo2019
Abbas Ishaq
Julia Schroder
Miss Edwards
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
et al.
Dietary restriction ameliorates age-related increase in DNA damage, senescence and inflammation in mouse adipose tissuey2018
Dario Melguizo Sanchis
Dr Yaobo Xu
Dheraj Taheem
Dr Min Yu
Dr Katarzyna Tilgner
et al.
iPSC modelling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors2018
Abbas Ishaq
Damien Dufour
Dr Kerry Cameron
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
et al.
Metabolic memory of dietary restriction ameliorates DNA damage and adipocyte size in mouse visceral adipose tissue2018
Dr Gavin Richardson
Dr Karim Bennaceur
Emily Dookun
Lilia Draganova
Dr Gabriele Saretzki
et al.
Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells2018
Dr Gabriele Saretzki
Telomeres, Telomerase and Ageing2018
Dr Dean Hallam
Dr Joseph Collin
Dr Sanja Bojic
Dr Valeria Chichagova
Dr Adriana Buskin
et al.
An iPSC patient specific model of CFH (Y402H) polymorphism displays characteristic features of AMD and indicates a beneficial role for UV light exposure2017
Dr Valeria Chichagova
Dr Dean Hallam
Dr Joseph Collin
Dr Adriana Buskin
Dr Gabriele Saretzki
et al.
Human iPSC disease modelling reveals functional and structural defects in retinal pigment epithelial cells harbouring the m.3243A>G mitochondrial DNA mutation2017
Dr Satomi Miwa
Dr Gabriele Saretzki
Telomerase and mTOR in the brain: The mitochondria connection2017
Dr Satomi Miwa
Dr Rafal Czapiewski
Tengfei Wan
Amy Bell
Kirsten Hill
et al.
Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria2016
Ammar Ashor
Shakir Chowdhury
Dr Clio Oggioni
Othman Qadir
Dr Kirsten Brandt
et al.
Inorganic Nitrate Supplementation in Young and Old Obese Adults Does Not Affect Acute Glucose and Insulin Responses but Lowers Oxidative Stress2016
Dr Clara Correia Melo
Francisco Marques
Rhys Anderson
Dr Graeme Hewitt
Dr Bernadette Carroll
et al.
Mitochondria are required for pro-ageing features of the senescent phenotype2016
Abbas Ishaq
Dr Peter Hanson
Dr Christopher Morris
Dr Gabriele Saretzki
Telomerase Activity is Downregulated Early During Human Brain Development2016
Dr Lili Zhu
Dr Aurora Gomez Duran
Dr Gabriele Saretzki
Dr Katarzyna Tilgner
Dario Melguizo Sanchis
et al.
The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages2016
Professor Bob Anderson
Dr Simon Tual-Chalot
Dr Rachael Redgrave
Rebecca Dodds
Dr Andrew Owens
et al.
The role of cardiomyocyte senescence and regeneration in Ageing2016
Professor Vijay Kunadian
Dr Murugu Veerasamy
Dr Hannah Sinclair
Dr Jonathan Batty
Meedya Sharifpour
et al.
Association of Telomere Length and Telomerase Activity with Clinical Parameters in Older Patients Undergoing Invasive Management Of non-ST Elevation Acute Coronary Syndrome2015
Dr Dean Hallam
Dr Gabriele Saretzki
Dietary restriction mitigates age-related accumulation of DNA damage, but not all changes in mouse corneal epithelium2015
Dr Alison Spilsbury
Dr Satomi Miwa
Professor Johannes Attems
Dr Gabriele Saretzki
The Role of Telomerase Protein TERT in Alzheimer's Disease and in Tau-Related Pathology In Vitro2015
Dr Karim Bennaceur
Mark Atwill
Nayef Al Zhrany
Jedrzej Hoffmann
Professor Bernard Keavney
et al.
Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism2014
Dr Diana Jurk
Dr Caroline Wilson
Dr Joao Passos
Professor Fiona Oakley
Clara Correia Melo
et al.
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice2014
Nouf Al-Ajmi
Dr Gabriele Saretzki
Dr Colin Miles
Professor Ioakim Spyridopoulos
Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short telomeres exacerbate the ageing phenotype2014
Dr Satomi Miwa
Dr Howsun Jow
Karen Baty
Amy Bell
Dr Rafal Czapiewski
et al.
Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice2014
Dr Katarzyna Tilgner
Dr Irina Neganova
Sun Yung
Chatcha Singhapol
Dr Gabriele Saretzki
et al.
A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors2013
Dr Katarzyna Tilgner
Dr Irina Neganova
Chatcha Singhapol
Dr Gabriele Saretzki
Jerome Evans
et al.
Brief Report: A Human Induced Pluripotent Stem Cell Model of Cernunnos Deficiency Reveals an Important Role for XLF in the Survival of the Primitive Hematopoietic Progenitors2013
Sun Yung
Dr Katarzyna Tilgner
Dr Maria Ledran
Dr Saba Habibollah
Dr Irina Neganova
et al.
Brief Report: Human Pluripotent Stem Cell Models of Fanconi Anemia Deficiency Reveal an Important Role for Fanconi Anemia Proteins in Cellular Reprogramming and Survival of Hematopoietic Progenitors2013
Chatcha Singhapol
Dr Deepali Pal
Dr Rafal Czapiewski
Dr Glyn Nelson
Dr Gabriele Saretzki
et al.
Mitochondrial Telomerase Protects Cancer Cells from Nuclear DNA Damage and Apoptosis2013
Dr Conor Lawless
Dr Diana Jurk
Dr Colin Gillespie
Dr Daryl Shanley
Dr Gabriele Saretzki
et al.
A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations2012
Dr Yan Jiang
Dr Katarzyna Tilgner
Dr Gabriele Saretzki
Professor Majlinda Lako
Professor Lyle Armstrong
et al.
Derivation and functional analysis of patient specific induced pluripotent stem cells (IPSCS) as an in vitro model of chronic granulomatous disease2012
Dr Yan Jiang
Dr Katarzyna Tilgner
Dr Gabriele Saretzki
Professor Majlinda Lako
Professor Lyle Armstrong
et al.
Derivation and Functional Analysis of Patient Specific Induced Pluripotent Stem Cells as an In Vitro Model of Chronic Granulomatous Disease2012
Dr Yan Jiang
Dr Katarzyna Tilgner
Dr Gabriele Saretzki
Professor Majlinda Lako
Professor Lyle Armstrong
et al.
Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease2012
Marta Gorowiec
Dr Lee Borthwick
Dr Sean Parker
Professor John Kirby
Dr Gabriele Saretzki
et al.
Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-beta 1-dependent mechanism2012
Avgi Tsolou
Dr Glyn Nelson
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult2012
Dr Gabriele Saretzki
Telomerase and Oxidative Stress in Embryonic Stem Cells2011
Dr Gabriele Saretzki
Telomerase beyond telomeres: New roles for an Old Enzyme2011
Mandy Maddick
Dr Satomi Miwa
Dr Diana Jurk
Dr Rafal Czapiewski
Dr Gabriele Saretzki
et al.
Adult-onset, short-term dietary restriction reduces cell senescence in mice2010
Dr Gabriele Saretzki
Cellular senescence in the development and treatment of cancer2010
Dr Joao Passos
Dr Glyn Nelson
Dr Cedric Simillion
Dr Carole Proctor
Dr Satomi Miwa
et al.
Feedback between p21 and reactive oxygen production is necessary for cell senescence2010
Professor Lyle Armstrong
Dr Katarzyna Tilgner
Dr Gabriele Saretzki
Dr Stuart Atkinson
Professor Miodrag Stojkovic
et al.
Human Induced Pluripotent Stem Cell Lines Show Stress Defense Mechanisms and Mitochondrial Regulation Similar to Those of Human Embryonic Stem Cells2010
Dr Darren Daniels
Dr Daniel Swan
Dr Gabriele Saretzki
Immediate and gradual gene expression changes in telomerase over-expressing fibroblasts2010
Dr Helen Tuppen
Dr Vanessa Hogan
Dr Langping He
Dr Mazhor Aldosary
Dr Gabriele Saretzki
et al.
The p.M292T NDUFS2 mutation causes complex I-deficient Leigh syndrome in multiple families2010
Dr Gabriele Saretzki
Well-known signaling proteins exert new functions in the nucleus and mitochondria2010
Dr Gabriele Saretzki
Telomerase, mitochondria and oxidative stress2009
Dr Chunbo Yang
Dr Rebecca Stewart
Dr George Anyfantis
Stuart Atkinson
Dr Gabriele Saretzki
et al.
A key role for telomerase reverse transcriptase unit in modulating human embryonic stem cell proliferation, cell cycle dynamics, and in vitro differentiation2008
Dr Sean Parker
Dr Lee Borthwick
Professor Christopher Ward
Dr James Lordan
Emeritus Professor Nick Europe-Finner
et al.
Airway epithelial cell senescence in the lung allograft2008
Dr Gabriele Saretzki
Theresia Walter
Dr Joao Passos
Dr Rebecca Stewart
Dr Simon Hoare
et al.
Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells2008
Dr Gabriele Saretzki
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length2008
Marta Gorowiec
Dr Lee Borthwick
Marcin Pekalski
Dr James Lordan
Emeritus Professor Nick Europe-Finner
et al.
Oxidative stress induces epithelial to mesenchymal transition in human lung epithelial cells through transforming groeth factor beta and integrin beta6-dependent mechanism2008
Dr Saeed Ahmed
Dr Joao Passos
Matthew Birket
Dr Heiko Peters
Professor Mark Birch-Machin
et al.
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress2008
Dr Joao Passos
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
DNA damage in telomeres and mitochondria during cellular senescence: Is there a connection?2007
Dr Gabriele Saretzki
Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart2007
Professor Thomas von Zglinicki
Dr Joao Passos
Dr Gabriele Saretzki
Mitochondria and telomeres: Strange bedfellows in cell senescence2007
Dr Joao Passos
Dr Gabriele Saretzki
Dr Saeed Ahmed
Dr Glyn Nelson
Torsten Richter
et al.
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence2007
Marta Gorowiec
Dr Sean Parker
Dr Lee Borthwick
Professor Christopher Ward
Dr James Lordan
et al.
Oxidative stress increases transforming growth factor-beta expression and drives epithelial to mesenchymal transition in human lung epithelial cells2007
Dr Joao Passos
Dr Glyn Nelson
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Oxygen free radicals in senescence: Are they signal transducers?2007
Dr Joao Passos
Dr Sharon Olijslagers
Dr Gabriele Saretzki
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
et al.
Premature senescence of mesothelial cells is associated with non-telomeric DNA damage2007
Dr Sean Parker
Professor Christopher Ward
Dr James Lordan
Emeritus Professor Nick Europe-Finner
Dr Gabriele Saretzki
et al.
Stress-induced premature senescence in airway epithelium and accelerated lung allograft aging2007
Matthew Birket
Professor Mark Birch-Machin
Dr Saeed Ahmed
Dr Gabriele Saretzki
Telomerase-dependent protection of mitochondrial DNA in response to oxidative stress2007
Dr Sean Parker
Marta Gorowiec
Dr Lee Borthwick
Dr James Lordan
Professor Christopher Ward
et al.
Transforming growth factor beta (TGF beta) induces cellular senescence in primary bronchial epithelial cells: A possible role in airway remodelling2007
Dr Gabriele Saretzki
Dr Glyn Nelson
Dr Sharon Olijslagers
Professor Thomas von Zglinicki
TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts2007
Dr Joao Passos
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Mechanisms and role of oxidative damage to telomeres2006
Dr Joao Passos
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Mechanisms and role of oxidative damage to telomeres2006
Dr Joao Passos
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
Mitochondrial dysfunction and cell senescence: Cause or consequence?2006
Jessie Jeyapalan
Dr Gabriele Saretzki
Alan Leake
Dr Michael Tilby
Professor Thomas von Zglinicki
et al.
Neuroblastoma cell apoptosis induction after cisplatin treatment is not telomere–dependent2006
Dr Sean Parker
Professor Christopher Ward
Dr Fiona Black
Dr James Lordan
Emeritus Professor Nick Europe-Finner
et al.
Premature senescence of airway epithelial cells: A possible role in airway remodelling after human lung transplantation2006
Jessie Jeyapalan
Dr Gabriele Saretzki
Alan Leake
Dr Michael Tilby
Professor Thomas von Zglinicki
et al.
Tumour-cell apoptosis after cisplatin treatment is not telomere dependent2006
Dr Gabriele Saretzki
Dr Judith Hall
Endogenous and ectopic expression of telomere regulating genes in chicken embryonic fibroblasts2005
Dr Gabriele Saretzki
Dr Judith Hall
Endogenous and ectopic expression of telomere regulating genes in chicken embryonic fibroblasts2005
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
Susan Jackson
Human cell senescence as a DNA damage response2005
Professor Lyle Armstrong
Dr Gabriele Saretzki
Dr Heiko Peters
Ilka Wappler
Dr Nicholas Hole
et al.
Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage2005
Professor Thomas von Zglinicki
Dr Carmen Martin-Ruiz
Dr Gabriele Saretzki
Telomeres, cell senescence and human ageing2005
Dr Gabriele Saretzki
Telomeres, senescence and longevity: The role of oxidative stress and antioxidants2005
Dr Gabriele Saretzki
The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo2005
Professor Lyle Armstrong
Professor Majlinda Lako
Dr Gabriele Saretzki
Dr Nicholas Hole
A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation2004
Dr Carmen Martin-Ruiz
Dr Gabriele Saretzki
Jessie Jeyapalan
Professor Thomas von Zglinicki
Stochastic Variation in Telomere Shortening Rate Causes Heterogeneity of Human Fibroblast Replicative Life Span2004
Dr Gabriele Saretzki
Professor Lyle Armstrong
Alan Leake
Professor Majlinda Lako
Professor Thomas von Zglinicki
et al.
Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells2004
Barbara Keys
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Telomere shortening in human fibroblasts is not dependent on the size of the telomeric-3′-overhang2004
Jessie Jeyapalan
Alan Leake
Dr Shaheda Ahmed
Dr Gabriele Saretzki
Dr Michael Tilby
et al.
The role of telomeres in etoposide induced tumor cell death2004
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
Susan Jackson
A DNA damage checkpoint response in telomere-initiated senescence2003
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Extracellular superoxide dismutase is a major antioxidant and slows down telomere shortening in human fibroblasts2003
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening2003
Dr Barry Davies
Islay Steele
Professor Richard Edmondson
Dr Simon Zwolinski
Dr Gabriele Saretzki
et al.
Immortalisation of human ovarian surface epithelium with telomerase and temperature-senstitive SV40 large T antigen2003
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress2003
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Telomerase as a promising target for human cancer gene therapy2003
Dr Gabriele Saretzki
Telomerase inhibition as cancer therapy2003
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines2002
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Replicative aging, telomeres, and oxidative stress2002
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Replicative aging, telomeres, and oxidative stress2002
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection2001
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase2001
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells2001
Dr Gabriele Saretzki
Telomerase activity in cervical smears2001
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
Regeneration der Telomeren als Basis zellulaerer Immortalitaet2000
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
Short telomeres in patients with vascular dementia: An indicator of low antioxidative capacity and a possible risk factor?2000
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Telomere length as a marker of oxidative stress in primary human fibroblast cultures2000
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
[Replicative senescence as a model of aging: the role of oxidative stress and telomere shortening--an overview]1999
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Modification of the replicative life-span of human fibroblasts by oxidative stress1999
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
Ribozymes inhibiting the catalytic subunit of human telomerase (hTERT)1999
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments1999
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Telomeres and human aging1999
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Preferential accumulation of single-stranded regions in telomeres of human fibroblasts1998