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Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci
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The process of malignant transformation in paediatric acute leukaemias is complex, requiring at least two deleterious events resulting in DNA damage. This damage ranges from point-mutations to double-strand DNA breaks leading to various types of chromosomal rearrangements. In this review we summarise the most common genetic aberrations for the three main subtypes of paediatric acute leukaemia: B-cell-precursor acute lymphoblastic leukaemia, T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Several genetic aberrations are independent prognostic factors, and are now used in risk stratification for treatment. Molecular pathways activated by genetic aberrations could provide potential molecular targets for novel therapies. Some genetic aberrations represent sensitive targets for molecular detection of minimal residual disease. This provides hope for the development of targeted therapies, effective against leukaemic cells.
Author(s): Szczepanski T, Harrison CJ, van Dongen JJM
Publication type: Review
Publication status: Published
Journal: Lancet Oncology
Print publication date: 07/05/2010
ISSN (print): 1470-2045
ISSN (electronic): 1474-5488
Publisher: ELSEVIER SCIENCE INC