Toggle Main Menu Toggle Search

Open Access padlockePrints

Eye movement recordings to investigate a supranuclear component in chronic progressive external ophthalmoplegia: a cross-sectional study

Lookup NU author(s): Philip Griffiths, Professor Patrick Chinnery


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Background It has been postulated that eye movement disorders in chronic progressive external ophthalmoplegia (CPEO) have a neurological as well as a myopathic component to them. Aim To investigate whether there is a supranuclear component to eye movement disorders in CPEO using eye movement recordings. Methods Saccade and smooth pursuit (SP) characteristics together with vestibulo-ocular reflex (VOR) gain and VOR suppression (VORS) gain in 18 patients with CPEO and 34 normal patients were measured using Eyelink II video-oculography. Results The asymptotic values of the peak velocity main sequence curves were reduced in the CPEO group compared to those of normal patients, with a mean of 161 degrees/s (95% CI 126 degrees/s to 197 degrees/s) compared with 453 degrees/s (95% CI 430 to 475 degrees/s), respectively. Saccadic latency was longer in CPEO (263 ms; 95% CI 250 to 278), compared to controls (185 ms; 95% CI 181 to 189). Smooth pursuit and VOR gains were impaired in CPEO, although this could be explained by non-supranuclear causes. VORS gain was identical in the two groups. Conclusions This study does not support a supranuclear component to the ophthalmoplegia of CPEO, although the increased latencies observed may warrant further investigation.

Publication metadata

Author(s): Ritchie AE, Griffiths PG, Chinnery PF, Davidson AW

Publication type: Article

Publication status: Published

Journal: British Journal of Ophthalmology

Year: 2010

Volume: 94

Issue: 9

Pages: 1165-1168

Print publication date: 24/06/2010

ISSN (print): 0007-1161

ISSN (electronic): 1468-2079

Publisher: BMJ Group


DOI: 10.1136/bjo.2009.165639


Altmetrics provided by Altmetric