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Lookup NU author(s): Philip Griffiths,
Professor Patrick Chinnery
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Background It has been postulated that eye movement disorders in chronic progressive external ophthalmoplegia (CPEO) have a neurological as well as a myopathic component to them. Aim To investigate whether there is a supranuclear component to eye movement disorders in CPEO using eye movement recordings. Methods Saccade and smooth pursuit (SP) characteristics together with vestibulo-ocular reflex (VOR) gain and VOR suppression (VORS) gain in 18 patients with CPEO and 34 normal patients were measured using Eyelink II video-oculography. Results The asymptotic values of the peak velocity main sequence curves were reduced in the CPEO group compared to those of normal patients, with a mean of 161 degrees/s (95% CI 126 degrees/s to 197 degrees/s) compared with 453 degrees/s (95% CI 430 to 475 degrees/s), respectively. Saccadic latency was longer in CPEO (263 ms; 95% CI 250 to 278), compared to controls (185 ms; 95% CI 181 to 189). Smooth pursuit and VOR gains were impaired in CPEO, although this could be explained by non-supranuclear causes. VORS gain was identical in the two groups. Conclusions This study does not support a supranuclear component to the ophthalmoplegia of CPEO, although the increased latencies observed may warrant further investigation.
Author(s): Ritchie AE, Griffiths PG, Chinnery PF, Davidson AW
Publication type: Article
Publication status: Published
Journal: British Journal of Ophthalmology
Print publication date: 24/06/2010
ISSN (print): 0007-1161
ISSN (electronic): 1468-2079
Publisher: BMJ Group
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