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Non-atheromatous arterial stenoses in atypical haemolytic uraemic syndrome associated with complement dysregulation

Lookup NU author(s): Professor Tim Goodship

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Abstract

Results. Stenoses of both carotid arteries, left subclavian and vertebral arteries, several intracranial, right humeral, several coronary, and all pulmonary arteries were demonstrated. At the age of 13 years, left subclavian and right cervical carotid arteries were occluded. Right carotid recanalization induced intracranial dissection and death. The child had a Lys350Asp factor B mutation. Conclusion. Arterial steno-occlusive lesions appear as potential complications of dysregulated complement activation in aHUS. Endovascular treatment should be considered cautiously in this setting.

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Author(s): Loirat C, Macher MA, Elmaleh-Berges M, Kwon T, Deschenes G, Goodship THJ, Majoie C, Davin JC, Blanc R, Savatovsky J, Moret J, Fremeaux-Bacchi V

Publication type: Article

Publication status: Published

Journal: Nephrology, Dialysis, Transplantation

Year: 2010

Volume: 25

Issue: 10

Pages: 3421-3425

Print publication date: 08/06/2010

ISSN (print): 0931-0509

ISSN (electronic): 1460-2385

Publisher: Oxford University Press

URL: http://dx.doi.org/10.1093/ndt/gfq319

DOI: 10.1093/ndt/gfq319

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