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Pancreas transplantation

Lookup NU author(s): Steven White, Professor James Shaw


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Since the introduction of pancreas transplantation more than 40 years ago, efforts to develop more minimally invasive techniques for endocrine replacement therapy have been in progress, yet this surgical procedure still remains the treatment of choice for diabetic patients with end-stage renal failure. Many improvements have been made in the surgical techniques and immunosuppressive regimens, both of which have contributed to an increasing number of indications for pancreas transplantation. This operation can be justified on the basis that patients replace daily injections of insulin with an improved quality of life but at the expense of a major surgical procedure and lifelong immunosuppression. The various indications, categories, and outcomes of patients having a pancreas transplant are discussed, particularly with reference to the effect on long-term diabetic complications. © 2009 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): White S, Shaw J, Sutherland D

Publication type: Review

Publication status: Published

Journal: The Lancet

Year: 2009

Volume: 373

Issue: 9677

Pages: 1808-1817

ISSN (print): 0140-6736

ISSN (electronic): 1474-547X


DOI: 10.1016/S0140-6736(09)60609-7

PubMed id: 19465236