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Browsing publications by Professor James Shaw.

Newcastle AuthorsTitleYearFull text
Dr Guy Taylor
Andy Shaw
Kieran Smith
Professor James Wason
Professor Emma Stevenson
et al.
Capturing the real-world benefit of residual β-cell function during clinically important time-periods in established Type 1 diabetes2022
Nicola Dyson
Dr Nicole Kattner
Minna Honkanen-Scott
Bethany Hunter
Jennifer Doyle
et al.
Development and Application of a Semi quantitative Scoring Method for Ultrastructural Assessment of Acute Stress in Pancreatic Islets2022
Xuefei Yu
Dr Catherine Arden
Dr Rolando Berlinguer Palmini
Dr Chun Chen
Carla Bradshaw
et al.
Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation2022
Dr Deborah Cornell
Dr Satomi Miwa
Dr Maria Georgiou
Dr Scott Anderson
Minna Honkanen-Scott
et al.
Pseudoislet aggregation of pancreatic β-cells improves glucose stimulated insulin secretion by altering glucose metabolism and increasing ATP production.2022
Dr Guy Taylor
Andy Shaw
Kieran Smith
Professor James Shaw
Dr Daniel West
et al.
Type 1 diabetes patients with different residual beta-cell function but similar age, HBA1c, and cardiorespiratory fitness have differing exercise-induced angiogenic cell mobilisation2022
Professor Derek Manas
Professor James Shaw
Colin Wilson
Steven White
105.2: Pancreas and Islet Transplantation in the UK During the COVID-19 Era2021
Professor James Shaw
Associations between glucose tolerance, insulin secretion, muscle and fat mass in cystic fibrosis2021
Dr Aaron Liew
Dr Augustin Brooks
Dr Anneliese Flatt
Professor James Shaw
Autoreactive T cell profiles are altered following allogeneic islet transplantation with alemtuzumab induction and re-emerging phenotype is associated with graft function2021
Andrea Masi
Dr Beate Haugk
Dr Chris Lamb
Professor Linda Sharp
Professor James Shaw
et al.
Endoscopic ultrasound (EUS) guided fine needle biopsy (FNB) formalin preserved paraffin embedded (FFPE) pancreatic tissue samples are a potential resource for microbiota analysis2021
Professor James Shaw
Evaluation of currently available screening methods for cystic fibrosis-related diabetes2021
Dr Francesco Zummo
Merilin Georgiou
Kirsty Cullen
Minna Honkanen-Scott
Professor James Shaw
et al.
Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis2021
Dr Rachel Stocker
Professor James Shaw
Dr Guy Taylor
Professor Miles Witham
Dr Daniel West
et al.
EXercise to Prevent frailty and Loss Of independence in insulin treated older people with DiabetEs (EXPLODE): protocol for a feasibility randomised controlled trial (RCT)2021
Nicola Dyson
Dr Nicole Kattner
Minna Honkanen-Scott
Bethany Hunter
Tracey Davey
et al.
P.112: Ultrastructural Assessment of the Associations of Obesity and Established Diabetes in Human Pancreata2021
Dr Ruth Owen
Emily Thompson
Professor James Shaw
Colin Wilson
Steven White
et al.
P.137: Multi-centre UK Analysis After SPK in Recipients With Type 2 Diabetes Mellitus2021
Dr Anneliese Flatt
Professor James Shaw
Pancreatic islet reserve in type 1 diabetes2021
Professor James Shaw
Restoring normal islet mass and function in type 1 diabetes through regenerative medicine and tissue engineering2021
Professor James Shaw
Screening Methods for Diagnosing Cystic Fibrosis-Related Diabetes: A Network Meta-Analysis of Diagnostic Accuracy Studies2021
Dr Anneliese Flatt
Professor James Shaw
The impact of islet mass, number of transplants, and time between transplants on graft function in a national islet transplant program2021
Dr Guy Taylor
Andy Shaw
Kieran Smith
Tess Capper
Jadine Scragg
et al.
Type 1 diabetes patients increase CXCR4+ and CXCR7+ haematopoietic and endothelial progenitor cells with exercise, but the response is attenuated2021
Yara Al-Selwi
Professor James Shaw
Dr Nicole Kattner
Understanding the Pancreatic Islet Microenvironment in Cystic Fibrosis and the Extrinsic Pathways Leading to Cystic Fibrosis Related Diabetes2021
Professor James Shaw
Steven White
US food and drug administration (FDA) panel endorses islet cell treatment for type 1 diabetes: A pyrrhic victory?2021
Dr Ahmad Al-Mrabeh
Dr Kieren Hollingsworth
Professor James Shaw
Professor Roy Taylor
2-year remission of type 2 diabetes and pancreas morphology: a post-hoc analysis of the DiRECT open-label, cluster-randomised trial2020
Dr Ahmad Al-Mrabeh
Dr Kieren Hollingsworth
Professor James Shaw
Professor Roy Taylor
2-year remission of type 2 diabetes and pancreas morphology: a post-hoc analysis of the DiRECT open-label, cluster-randomised trial2020
Dr Guy Taylor
Kieran Smith
Andy Shaw
Professor Emma Stevenson
Professor James Shaw
et al.
Bone turnover and metabolite responses to exercise in people with and without long-duration type 1 diabetes: a case-control study2020
Dr Aaron Liew
Dr Anneliese Flatt
Ruth Wood
Professor James Shaw
Characterization of pre-transplant psychosocial burden in an integrated national islet transplant program2020
Dr Nicole Kattner
Nicola Dyson
Dr Yvonne Bury
Dr Dina Tiniakos
Tracey Davey
et al.
Development and validation of a quantitative electron microscopy score to assess acute cellular stress in the human exocrine pancreas2020
Professor James Shaw
Donor insulin use predicts beta-cell function after islet transplantation2020
Professor James Shaw
Dr Aaron Liew
Efficacy and safety of a sodium-glucose co-transporter-2 inhibitor versus placebo as an add-on therapy for people with type 2 diabetes inadequately treated with metformin and a dipeptidyl peptidase-4 inhibitor: a systematic review and meta-analysis of randomised controlled trials2020
Dr Michael White
Dr Rashmi Maheshwari
Dr Scott Anderson
Dr Rolando Berlinguer Palmini
Claire Jones
et al.
In situ analysis reveals that CFTR is expressed in only a small minority of β-cells in normal adult human pancreas2020
Dr Guy Taylor
Kieran Smith
Tess Capper
Jadine Scragg
Dr Ayat Bashir
et al.
Postexercise Glycemic Control in Type 1 Diabetes Is Associated With Residual β-Cell Function2020
Sarah Armour
Dr Scott Anderson
Dr Yuchun Ding
Dr Christopher Carey
Dr Rashmi Maheshwari
et al.
Reduced expression of the co-regulator TLE1 in type 2 diabetes is associated with increased islet α-cell number2020
Professor James Shaw
Dr Aaron Liew
Targeting CXCR1/2 does not improve insulin secretion after pancreatic islet transplantation: A phase 3, double-blind, randomized, placebo-controlled trial in type 1 diabetes2020
Dr Stuart Little
Professor James Shaw
Development and psychometric validation of the novel Glucose Monitoring Experiences Questionnaire (GME-Q) among adults with type 1 diabetes2019
Dr Bill Scott
Professor Derek Manas
Professor James Shaw
Oxygen Perfusion (Persufflation) of Human Pancreata Enhances Insulin Secretion and Attenuates Islet Proinflammatory Signaling2019
Dr Anneliese Flatt
Dr Stuart Little
Dr Thomas Chadwick
Ruth Wood
Professor James Shaw
et al.
Predictors of Recurrent Severe Hypoglycemia in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia During the HypoCOMPaSS Study2019
Dr Stuart Little
Professor James Shaw
Satisfaction with the Use of Different Technologies for Insulin Delivery and Glucose Monitoring Among Adults with Long-Standing Type 1 Diabetes and Problematic Hypoglycemia: 2-Year Follow-Up in the HypoCOMPaSS Randomized Clinical Trial2019
Dr Rashmi Maheshwari
Professor James Shaw
Dr Michael White
Short-term CFTR inhibition reduces islet area in C57BL/6 mice2019
Dr Anneliese Flatt
Steven White
Professor James Shaw
β-Cell and renal transplantation options for diabetes2019
Professor James Shaw
Steven White
Defining Outcomes for β-cell Replacement Therapy in the Treatment of Diabetes: A Consensus Report on the Igls Criteria from the IPITA/EPITA Opinion Leaders Workshop2018
Professor James Shaw
Does islet size really influence graft function following clinical islet transplantation?2018
Dr Scott Anderson
Dr Ali Aldibbiat
Professor James Shaw
Improved Beta-Cell Differentiation and Function in Isolated Islets Established in Dynamic Culture to Reduce Hypoxia2018
Dr Scott Anderson
Dr Michael White
Sarah Armour
Rashmi Maheshwari
Dr Dina Tiniakos
et al.
Loss of end-differentiated β-cell phenotype following pancreatic islet transplantation2018
Dr Stuart Little
Dr Deborah Stocken
Emerita Professor Sally Marshall
Professor James Shaw
Sustained reduction in severe hypoglycemia in adults with type 1 diabetes complicated by impaired awareness of hypoglycemia: 2-year follow-up in the HypoCOMPaSS randomized clinical trial2018
Professor James Shaw
Donor-Specific Antibodies - The Devil Is in the Detail2017
Dr Francesco Zummo
Kirsty Cullen
Minna Honkanen-Scott
Professor James Shaw
Professor Penny Lovat
et al.
Glucagon-like peptide-1 protects pancreatic beta-cells from death by increasing autophagic flux and restoring lysosomal function2017
Dr Christopher Stewart
Professor Mark Walker
Professor Emma Stevenson
Professor James Shaw
Dr Daniel West
et al.
Gut microbiota of Type 1 diabetes patients with good glycaemic control and high physical fitness is similar to people without diabetes: an observational study2017
Professor James Shaw
The big pet diabetes survey: Perceived frequency and triggers for euthanasia2017
Sarah Armour
Dr Scott Anderson
Professor James Shaw
Dr Michael White
A Novel Role for Tle3 in Maintaining Beta Cell Identity2016
Alexander Popov
Dr Bill Scott
Dr Jinju Chen
Professor James Shaw
Professor Kenneth Dalgarno
et al.
3D manufactured islet micro-tissues for the treatment of type-1 diabetes2016
Professor Mark Walker
Professor James Shaw
Professor Emma Stevenson
Dr Daniel West
Administering a small rapid-acting insulin bolus 3 h after eating a mixed macronutrient meal improves postprandial glucose control, without hypoglycaemia, in people with Type 1 diabetes2016
Professor Mark Walker
Dr Dean Allerton
Professor Emma Stevenson
Professor James Shaw
Dr Daniel West
et al.
Carbohydrate counting at meal time followed by a small secondary postprandial bolus injection at 3 hours prevents late hyperglycemia, without hypoglycemia, after a high-carbohydrate high-fat meal in Type 1 diabetes2016
Dr Stuart Little
Professor James Shaw
Characterizing problematic hypoglycaemia: iterative design and preliminary psychometric validation of the Hypoglycaemia Awareness Questionnaire (HypoA-Q)2016
Dr Bill Scott
Minna Honkanen-Scott
Dr Julian De Havilland
Professor Derek Manas
Professor James Shaw
et al.
Diversifying the Indications for Pancreas Resection and Autologous Islet Cell Transplantation (IAT) in both Adults and Children2016
Dr Scott Anderson
Sarah Armour
Dr Michael White
Dr Thomas Berney
Professor James Shaw
et al.
Evidence for Beta Cell Dedifferentiation as a Cause for Sustained Graft Dysfunction Following Peri Engraftment Hypoxia in Clinical Islet Transplantation2016
Minna Honkanen-Scott
Dr Julian De Havilland
Professor Derek Manas
Professor James Shaw
Professor Anne Dickinson
et al.
Expanding the indications for pancreas resection and autologous islet cell transplantation (IAT) in both adults and children2016
Dr Aaron Liew
Vish Bhattacharya
Professor James Shaw
Professor Gerard Stansby
Gene therapy for peripheral arterial disease (Protocol)2016
Dr Francesco Zummo
Kirsty Cullen
Professor Penny Lovat
Professor James Shaw
Dr Catherine Arden
et al.
Glucagon-like peptide-1 requires EPAC activity to restore autophagy and protect pancreatic beta cells from cell death2016
Dr Scott Anderson
Dr Helen Marshall
Professor James Shaw
Hypoxia-induced beta cell dedifferentiation: the missing link in islet transplant dysfunction?2016
Sarah Armour
Professor James Shaw
Dr Michael White
Limitation of glucotoxicity-induced beta-cell dedifferentiation and alpha-cell transition following Nkx6.1 overexpression2016
Dr Stuart Little
Professor James Shaw
Low-blood glucose avoidance training improves glycemic variability in adults with type 1 diabetes complicated by impaired awareness of hypoglycemia: HypoCOMPaSS trial2016
Dr Helen Marshall
Professor James Shaw
Methylation specific cell free DNA to monitor islet autoimmunity in Type 1 diabetes2016
Dr Helen Marshall
Professor James Shaw
Methylation specific cell free DNA to monitor islet autoimmunity in Type 1 diabetes2016
Dr Stuart Little
Dr Thomas Chadwick
Dr Deborah Stocken
Catherine Brennand
Emerita Professor Sally Marshall
et al.
Recovery of hypoglycemia awareness in longstanding type 1 diabetes: A multicenter 2×2 factorial randomized controlled trial comparing insulin pump with multiple daily injections and continuous with conventional glucose selfmonitoring (HypoCOMPaSS)2016
Dr Michael White
Professor James Shaw
Professor Roy Taylor
Type 2 Diabetes: The Pathologic Basis of Reversible β-Cell Dysfunction2016
Dr Gus Brooks
Dr Aaron Liew
Dr Helen Marshall
Dr Ali Aldibbiat
Professor Neil Sheerin
et al.
De Novo Donor-Specific HLA Antibodies Are Associated With Rapid Loss of Graft Function Following Islet Transplantation in Type 1 Diabetes2015
Professor Mark Walker
Professor Mike Trenell
Professor James Shaw
Dr Daniel West
A combined basal-bolus insulin dose reduction strategy for preventing exercise-induced hypoglycaemia does not cause hormonal, metabolic or inflammatory disturbances in Type 1 diabetes2015
Professor Mark Walker
Professor Mike Trenell
Professor James Shaw
A novel strategy that prevents early- and late-onset nocturnal hypoglycaemia following evening exercise in Type 1 diabetes2015
Dr Francesco Zummo
Kirsty Cullen
Professor Penny Lovat
Professor James Shaw
Dr Catherine Arden
et al.
An emerging role for autophagy in the regulation of beta cell survival by glucagon-like peptide-12015
Sarah Armour
Professor James Shaw
Dr Michael White
An in vitro model of beta cell de-differentiation and potential alpha cell reprogramming2015
Dr Stuart Little
Professor James Shaw
Associations with hyperglycaemia avoidance among adults with long-standing Type 1 diabetes and impaired awareness of hypoglycaemia: baseline characteristics from the HypoCOMPaSS Study2015
Dr Stuart Little
Professor James Shaw
Cardiac autonomic regulation during experimental hypoglycaemia in type 1 diabetes with impaired awareness of hypoglycaemia2015
Dr Stuart Little
Professor James Shaw
Cardiac autonomic regulation during experimental hypoglycaemia in Type 1 diabetes with impaired awareness of hypoglycaemia (IAH)2015
Dr Aaron Liew
Vish Bhattacharya
Professor James Shaw
Professor Gerard Stansby
Cell Therapy for Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials2015
Professor Mark Walker
Professor James Shaw
Professor Emma Stevenson
Dr Daniel West
Comparison of appetite responses to high- and low-glycemic index postexercise meals under matched insulinemia and fiber in type 1 diabetes2015
Dr Scott Anderson
Dr Michael White
Dr Helen Marshall
Professor James Shaw
Contaminating exocrine tissue as a source of MCP-1 in islet transplantation2015
Dr Augustin Brooks
Emeritus Professor Philip Home
Dr Nick Steen
Professor James Shaw
Demonstration of an Intrinsic Relationship Between Endogenous C-Peptide Concentration and Determinants of Glycemic Control in Type 1 Diabetes Following Islet Transplantation2015
Dr Bill Scott
Minna Honkanen-Scott
Dr Julian De Havilland
Hany Gabra
Richard Charnley
et al.
Expanding the indications for paediatric and adult autologous islet transplantation2015
Dr Francesco Zummo
Kirsty Cullen
Professor Penny Lovat
Professor James Shaw
Dr Catherine Arden
et al.
Glucagon-like peptide 1 protects pancreatic beta cells from programmed cell death: a role for autophagy2015
Dr Stuart Little
Professor James Shaw
Hypoglycaemia avoidance training improves glucose variability in Type 1 diabetes (HypoCOMPaSS Study)2015
Dr Daniel West
Professor Mark Walker
Professor James Shaw
Dr Fahad Ahmed
Stephanie Wijaya
et al.
Inflammation and the acute endothelial progenitor cell response to submaximal running exercise in males with and without Type 1 diabetes2015
Professor Mark Walker
Professor Emma Stevenson
Professor James Shaw
Dr Daniel West
Insulin therapy and dietary adjustments to normalise glycaemia and prevent nocturnal hypoglycaemia after evening exercise in Type 1 diabetes: a randomized controlled trial2015
Dr Michael White
Sarah Armour
Professor James Shaw
Limiting human beta cell de-differentiation by small molecule inhibitors of the transforming growth factor beta (TGF-beta) pathway2015
Professor Mark Walker
Professor James Shaw
Dr Daniel West
Subjective and hormonal appetite responses to high and low glycaemic index post-exercise meals, under matched insulinaemia and fibre in Type 1 diabetes2015
Dr Julian De Havilland
Minna Honkanen-Scott
Richard Charnley
Professor Derek Manas
Professor James Shaw
et al.
Successful autologous islet transplantation post-frey's procedure using a side-vented 'therapeutic infusion needle' for improved enzyme delivery2015
Professor Mark Walker
Dr Fahad Ahmed
Stephanie Wijaya
Professor James Shaw
Dr Jolanta Weaver
et al.
The inflammation, vascular repair and injury responses to exercise in fit males with and without Type 1 diabetes: an observational study2015
Professor James Shaw
The UK Pancreas Allocation Scheme for Whole Organ and Islet Transplantation2015
Professor Mark Walker
Professor Mike Trenell
Professor Emma Stevenson
Professor James Shaw
Dr Daniel West
et al.
A Low-Glycemic Index Meal and Bedtime Snack Prevents Postprandial Hyperglycemia and Associated Rises in Inflammatory Markers, Providing Protection From Early but Not Late Nocturnal Hypoglycemia Following Evening Exercise in Type 1 Diabetes2014
Dr Stuart Little
Professor James Shaw
Coefficient of variation from continuous glucose monitoring is associated with the frequency of hypoglycaemia in Type 1 diabetes complicated by impaired awareness of hypoglycaemia: baseline analysis of the HypoCOMPaSS study group2014
Professor James Shaw
Examining Glycaemic Control and Variability Utilising the Medtronic Continuous Glucose Monitoring System (CGMS) In Pre And Post CSII Therapy2014
Dr Gus Brooks
Professor James Shaw
Home Urine C-Peptide Creatinine Ratio Can Be Used to Monitor Islet Transplant Function2014
Dr Michael White
Professor James Shaw
Involvement of Notch signaling in Human Beta-Cell Dedifferentiation2014
Professor James Shaw
David Talbot
Portal Venous Oxygen Persufflation of the Donation after Cardiac Death pancreas in a rat model is superior to static cold storage and hypothermic machine perfusion2014
Dr Stuart Little
Dr Thomas Chadwick
Dr Deborah Stocken
Catherine Brennand
Emerita Professor Sally Marshall
et al.
Recovery of Hypoglycemia Awareness in Long-Standing Type 1 diabetes: A Multicenter 2x2 Factorial Randomized Controlled Trial Comparing Insulin Pump with Multiple Daily Injections and Continuous with Conventional Glucose Self-Monitoring (HypoCOMPaSS)2014
Dr Stuart Little
Dr Thomas Chadwick
Dr Deborah Stocken
Catherine Brennand
Emerita Professor Sally Marshall
et al.
Response to Comment on Little et al. Recovery of Hypoglycemia Awareness in Long-standing Type 1 Diabetes: A Multicenter 2 x 2 Factorial Randomized Controlled Trial Comparing Insulin Pump With Multiple Daily Injections and Continuous With Conventional Glucose Self-monitoring (HypoCOMPaSS). Diabetes Care 2014;37:2114-21222014
Dr Stuart Little
Professor James Shaw
Severe hypoglycaemia in type 1 diabetes mellitus: underlying drivers and potential strategies for successful prevention2014
Dr Emma Fairhall
Dr Karen Wallace
Steven White
Professor James Shaw
Professor Alastair Burt
et al.
Adult human exocrine pancreas differentiation to hepatocytes – potential source of a human hepatocyte progenitor for use in toxicology research2013
Dr Gus Brooks
Dr Ali Aldibbiat
Professor Mark Walker
Professor James Shaw
Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations2013
Dr Michael White
Dr Helen Marshall
Professor James Shaw
Beta cell dedifferentiation: Evidence for ductal progenitors as a source of new beta cells?2013
Dr Michael White
Dr Helen Marshall
Dr Aimen Amer
Dr Trevor Booth
Steven White
et al.
Expression of Mesenchymal and α-Cell Phenotypic Markers in Islet β-Cells in Recently Diagnosed Diabetes2013
Dr Helen Marshall
Professor James Shaw
Professor Derek Manas
Human Pancreas Persufflation Ameliorates Hypoxia-Induced Impairment of Islet Function Post-Isolation2013
Professor James Shaw
International workshop: islet transplantation without borders enabling islet transplantation in Greece with international collaboration and innovative technology2013
Professor James Shaw
Islet Activity and Outcomes in the United Kingdom2013
Professor James Shaw
Islet transplantation and return of hypoglycaemic awareness: the same Driver and Vehicle Licensing Agency (DVLA) rules still apply2013
Dr Stuart Little
Professor James Shaw
Patients with longstanding type 1 diabetes show improved self awareness of hypoglycaemia measured during clamped hypoglycaemic challenges after a six month intensive treatment period in the HypoCOMPASS Study: comparison of optimised multiple daily injections (MDI) and continuous insulin infusion therapy (CSII) with or without adjunctive real-time continuous glucose monitoring (RTCGM)2013
Afsara Ahmmed
Dr Augustin Brooks
Dr Kieren Hollingsworth
Professor Mike Trenell
Professor James Shaw
et al.
Quantification of hepatic steatosis before and after intraportal pancreatic islet transplantation2013
Dr Helen Marshall
Professor James Shaw
Rapid detection of hypoxic islet stress by oxygen consumption rate using a standardised beta cell model2013
Dr Augustin Brooks
Dr Ali Aldibbiat
Professor Mark Walker
Professor James Shaw
Restoration of endogenous C-peptide by islet transplantation is associated with increased duration of normoglycaemia and reduced blood glucose variability in recipients with Type 1 diabetes2013
Dr Stuart Little
Annette Lane
Dr Thomas Chadwick
Emerita Professor Sally Marshall
Professor James Shaw
et al.
Restoration of self-awareness of hypoglycemia in adults with long-standing Type 1 diabetes: hyperinsulinemic-hypoglycemic clamp substudy results from the HypoCOMPaSS trial2013
Dr Gus Brooks
Professor James Shaw
Urine c-peptide creatinine ratio can be used for home monitoring of islet transplant function2013
Dr Stuart Little
Dr Thomas Chadwick
Catherine Brennand
Dr Julia Stickland
Emerita Professor Sally Marshall
et al.
Comparison of Optimised MDI versus Pumps with or without Sensors in Severe Hypoglycaemia (the Hypo COMPaSS trial)2012
Dr Matthew Thomas
Colin Wilson
Professor Derek Manas
Professor Mark Walker
Professor James Shaw
et al.
Endoscopic Botulinum Toxin Injection for the Treatment of Diabetic Gastropathy in Pancreas and Islet-cell Transplant Patients2012
Professor James Shaw
Dearbhaile Church
Evaluation of a Quality-of-Life Tool for Dogs with Diabetes Mellitus2012
Dr Susan Campbell
Dr Ali Aldibbiat
Christopher Huggins
Dr Audrey Brown
Professor James Shaw
et al.
Novel diabetes mellitus treatment: mature canine insulin production by canine striated muscle through gene therapy2012
Dr Susan Campbell
Professor James Shaw
Dr Marsha Cochrane
Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)2012
Dr Ali Aldibbiat
Dr Graham Holliman
Linda Ferguson
Kenneth Brigham
Dr Josephine Wardle
et al.
Validation of Islet Transport From a Geographically Distant Isolation Center Enabling Equitable Access and National Health Service Funding of a Clinical Islet Transplant Program for England2012
Dr Stuart Little
Professor James Shaw
Emeritus Professor Philip Home
Hypoglycemic rates with basal insulin analogs2011
Professor James Shaw
Insulin Pump Therapy With Automated Insulin Suspension in Response to Hypoglycemia: Reduction in nocturnal hypoglycemia in those at greatest risk2011
Dr Michael White
Hussain Al-Turaifi
Dr Graham Holliman
Dr Ali Aldibbiat
Aiman Mahmoud
et al.
Pluripotency-associated stem cell marker expression in proliferative cell cultures derived from adult human pancreas2011
Dr Karen Wallace
Professor James Shaw
Professor Alastair Burt
Professor Matthew Wright
Prolonged glucocorticoid exposure results in the appearance of hepatocytes in the adult pancreas2011
Professor James Shaw
Fiona Campbell
ABCD position statement on continuous glucose monitoring: Use of glucose sensing in outpatient clinical diabetes care2010
Steven White
Professor James Shaw
Emeritus Professor Paul Flecknell
Professor Alastair Burt
Professor Matthew Wright
et al.
Chronic elevated systemic glucocorticoid results in widespread pancreatic-hepatic trans-differentiation in vivo2010
Professor Danny MacKinnon
Professor James Shaw
Devolution as Process: Institutional Structures, State Personnel and Transport Policy in the United Kingdom2010
Dr Shaikh Abdul Shakoor
Dr Ali Aldibbiat
Lorna Ingoe
Dr Susan Campbell
Dr Latika Sibal
et al.
Endothelial Progenitor Cells in Subclinical Hypothyroidism: The Effect of Thyroid Hormone Replacement Therapy2010
Professor James Shaw
Evaluation of a Quality-of-Life Tool for Cats with Diabetes Mellitus2010
Professor Danny MacKinnon
Professor James Shaw
Labour, organisational rescaling and the politics of production: union renewal in the privatised rail industry2010
Professor Matthew Wright
Dr Karen Wallace
Professor James Shaw
Professor Alastair Burt
Steven White
et al.
Long term glucocorticoid therapy leads to pancreatic acinar trans-differentiation into hepatocyte-like cells2010
Professor James Shaw
Patient-reported outcomes following islet cell or pancreas transplantation (alone or after kidney) in Type 1 diabetes: a systematic review2010
Christopher Huggins
Professor James Shaw
Transgene expression in mononuclear muscle cells not infiltrating inflammatory cells following intramuscular plasmid gene electrotransfer2010
Professor James Shaw
Algorithm for the introduction of rapid-acting insulin analogues in patients with type 2 diabetes on basal insulin therapy2009
Dr Karen Wallace
Professor James Shaw
Professor Alastair Burt
Professor Matthew Wright
Chronic Elevated Systemic Glucocorticocoid Results in Widespread Pancreatic-Hepatic Trans-Differentiation In Vivo2009
Dr Latika Sibal
Dr Ali Aldibbiat
Dr Sharad Agarwal
Crispian Oates
Dr Salman Razvi
et al.
Circulating endothelial progenitor cells, endothelial function, carotid intima-media thickness and circulating markers of endothelial dysfunction in people with type 1 diabetes without macrovascular disease or microalbuminuria2009
Dr Ali Aldibbiat
Susan Stamp
Dr Brian Shenton
Professor James Shaw
Dr Noel Carter
et al.
Improved Preservation of Non Heart-Beating- Donor Pancreases Prior to Islet Isolation Using Portal Venous Oxygen Persufflation.2009
Aiman Mahmoud
Dr Catherine Arden
Dr Audrey Brown
Dr Susan Campbell
Dr Ali Aldibbiat
et al.
Muscle targeted gene therapy for diabetes mellitus: role of proteasomal decay in mutant proinsulin plasmid efficiency2009
Aiman Mahmoud
Dr Ali Aldibbiat
Hussain Al-Turaifi
Christopher Huggins
Professor James Shaw
et al.
Muscle-targeted gene transfer enables continuous secretion of GLP-1 and exendin-4 in mice2009
Steven White
Professor James Shaw
Pancreas transplantation2009
Dr Ali Aldibbiat
Susan Stamp
Dr Brian Shenton
Professor James Shaw
David Talbot
et al.
Portal venous oxygen persufflation for the preservation of non heart-beating-donor pancreases prior to islet isolation2009
Dr Catherine Arden
Dr Laura Hampson
Professor James Shaw
Dr Ali Aldibbiat
Dr Graham Holliman
et al.
A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic β-cells2008
Dr Ali Aldibbiat
Dr Susan Campbell
Christopher Huggins
Professor James Shaw
Development of muscle targeted gene therapy with a mutant canine proinsulin plasmid for the treatment of canine diabetes mellitus2008
Dr Ali Aldibbiat
Dr Graham Holliman
Dr Susan Campbell
Professor James Shaw
Expression of pluripotent stem cell markers within intact adult human pancreas and proliferative adherent cell cultures derived from digested pancreas2008
Aiman Mahmoud
Dr Ali Aldibbiat
Dr Susan Campbell
Dr Graham Holliman
Dr Kathleen Scougall
et al.
Expression, storage and rapid regulated secretion of active glucagon like peptide-1 following muscle-targeted gene transfer2008
Dr Ali Aldibbiat
Dr Graham Holliman
Hussain Al-Turaifi
Dr Susan Campbell
Professor James Shaw
et al.
Generation of insulin-synthesising pseudo-islets from adult stem cell cultures derived from the human pancreas2008
Dr Ali Aldibbiat
Dr Kathleen Scougall
Dr Susan Campbell
Professor James Shaw
Inability to process and store proinsulin in transdifferentiated pancreatic acinar cells lacking the regulated secretory pathway2008
Aiman Mahmoud
Dr Ali Aldibbiat
Christopher Huggins
Dearbhaile Church
Professor James Shaw
et al.
Muscle-targeted gene therapy for the treatment of diabetes mellitus: Investigating the role of the immune system when employing mutant (pro)insulin2008
Dr Susan Campbell
Dr Ali Aldibbiat
Christopher Huggins
Professor James Shaw
Novel furin-cleavable human insulin construct (hppI5) for muscle targeted gene therapy in diabetes mellitus2008
Dr Susan Campbell
Dr Ali Aldibbiat
Dr Clive Butler
Professor James Shaw
Selenium stimulates pancreatic beta-cell gene expression and enhances islet function2008
Dr Latika Sibal
Dr Ali Aldibbiat
Crispian Oates
Dr Jolanta Weaver
Professor James Shaw
et al.
The influence of the presence of retinopathy on the circulating endothelial progenitor cell counts, endothelial function and carotid intima-media thickness in type I diabetes2008
Dr Ali Aldibbiat
Dr Mike Cox
Dr Nicola Leech
Professor James Shaw
A randomized pilot study in type 1 diabetes complicated by severe hypoglycaemia, comparing rigorous hypoglycaemia avoidance with insulin analogue therapy, CSII or education alone2007
Dr Catherine Arden
Dr Alison Trainer
Dr Kathleen Scougall
Professor James Shaw
Professor Loranne Agius
et al.
Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic β-cells: Evidence for cellular instability of catalytic activity2007
Professor James Shaw
Does one size really fit all? Only by considering individual preferences and priorities will the true impact of insulin pump therapy on quality of life be determined2007
Dr Latika Sibal
Dr Ali Aldibbiat
Dr Jolanta Weaver
Dr Salman Razvi
Crispian Oates
et al.
Endothelial dysfunction and circulating endothelial progenitor cells in young people with type 1 diabetes2007
Dr Latika Sibal
Dr Ali Aldibbiat
Dr Sharad Agarwal
Dr Jolanta Weaver
Dr Salman Razvi
et al.
Endothelial dysfunction, carotid intima media thickness and circulating endothelial progenitor cells in young people with Type 1 diabetes2007
Dr Ali Aldibbiat
Dr Brian Shenton
Professor James Shaw
Dr Noel Carter
Professor Derek Manas
et al.
Hypothermic machine perfusion for preservation and viability assessment of porcine non-heart-beating-donor pancreas: Initial results2007
Christopher Huggins
Professor John Kirby
Professor James Shaw
In vitro and in vivo evaluation of intrinsic immunogenicity of reporter and insulin gene therapy plasmids2007
Dr Ali Aldibbiat
Professor Anne Dickinson
Professor Derek Manas
Professor James Shaw
[abstract] Confirmation of maintained sterility, viability and function in clinical-grade human islets following transport from an approved geographically-distance isolation facility2006
Dr Catherine Arden
Dr Kathleen Scougall
Professor James Shaw
Professor Loranne Agius
[abstract] Generation of MIN6 stable cell lines expressing GFP-tagged glucokinase for cellular analysis of glucokinase mutants2006
Dr Latika Sibal
Dr Ali Aldibbiat
Ian Harvey
Dr Brian Shenton
Dr Graham Holliman
et al.
[abstract] Identification and quantification of circulating endothelial progenitor cells in individuals with Type 1 diabetes and non-diabetic controls2006
Emma Heslop
Dr Ali Aldibbiat
Dr Nicola Leech
Professor James Shaw
[abstract] Safety and efficacy of continuous subcutaneous insulin infusion therapy in relation to pre-intervention HbA1c2006
Dr Catherine Arden
Professor James Shaw
Professor Loranne Agius
Catalytic instability of the glucokinase MODY-2 mutants V62M and G72R in pancreatic beta cells2006
Dr Graham Holliman
Dr Ali Aldibbiat
Dr Susan Campbell
Professor Derek Manas
Professor Majlinda Lako
et al.
Expression of the pluripotent stem cell marker OCT-4 in normal adult human pancreas2006
Professor James Shaw
Plasmid-mediated muscle-targeted gene therapy for circulating therapeutic protein replacement: A tale of the tortoise and the hare?2006
Marcus Wilson
Dr Kathleen Scougall
Dr Elizabeth McIntyre
Professor James Shaw
Storage, processing and rapid regulated secretion of insulin following gene transfer to human muscle2006
Professor James Shaw
David Talbot
Audit of diabetes in a renal transplant population2005
Dr Ali Aldibbiat
Dr Kathleen Scougall
Dr Susan Campbell
Professor James Shaw
Proinsulin overexpression as a tool for characterization of β-cell phenotype in transdifferentiation studies2005
Jarupa Ratanamart
Christopher Huggins
Professor James Shaw
Tetracycline-regulated human proinsulin secretion following plasmid-mediated gene transfer to muscle2005
Dr Kathleen Scougall
Dr Elizabeth McIntyre
Professor James Shaw
Tetracycline-regulated secretion of human (pro)insulin following plasmid-mediated transfection of human muscle2005
Dr Ali Aldibbiat
Dr Kathleen Scougall
Dr Susan Campbell
Professor James Shaw
Characterisation of pancreatic acinar cells for endocrine potential and determination of proinsulin processing and secretion following transfection with a human preproinsulin gene2004
Jarupa Ratanamart
Dr Kathleen Scougall
Professor John Kirby
Professor James Shaw
Establishment of an in vitro bioassay for immunogenicity of bacterial lipopolysaccharide and unmethylated CpG motifs in plasmid-derived gene therapy vectors2004
Robert Campbell
Professor James Shaw
Generation of glucose-responsive insulin expression constructs for use in a muscle-targeted gene therapy approach to the treatment of diabetes mellitus2004
Marcus Wilson
Dr Kathleen Scougall
Dr Elizabeth McIntyre
Emeritus Professor Steve Yeaman
Professor Mark Walker
et al.
Towards muscle-targeted gene therapy for diabetes: Tetracycline-repressible transcriptional regulation of (pro)insulin secretion in human muscle2004
Magdalene Wilson
Dr Elizabeth McIntyre
Dr Kathleen Scougall
Professor Mark Walker
Emeritus Professor Steve Yeaman
et al.
Tetracycline-regulated (pro)insulin secretion and processing to mature insulin following plasmid-mediated transfection of human muscle2003
Dr Kathleen Scougall
Professor James Shaw
Tetracycline-regulated secretion of human insulin in a transfected non-endocrine cell line2003
Dr Kathleen Scougall
Professor James Shaw
Tetracycline-regulated secretion of human insulin in transfected primary myoblasts2003
Professor James Shaw
Cushing's syndrome during pregnancy: Curative Adrenalectomy at 31 Weeks Gestation2002
Professor James Shaw
Development of alternatives to insulin injection by genetic engineering2002
Professor James Shaw
Genetic engineering in the treatment of diabetes2002
Professor Nigel Unwin
Professor James Shaw
Emeritus Professor Sir George Sir George Alberti
Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention2002
Professor James Shaw
Retrospective audit of individuals with Type 1 diabetes mellitus with and without altered hypoglycaemia awareness / severe hypoglycaemia attending Newcastle Diabetes Centre2002
Professor James Shaw
Secretion of bioactive human insulin following plasm id-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo2002
Emeritus Professor Sir George Sir George Alberti
Professor James Shaw
Global and societal implications of the diabetes epidemic2001
Dr Kathleen Scougall
Professor James Shaw
Tetracycline-regulated secretion of mature human insulin in transfected primary rat myoblasts2001
Dr Kathleen Scougall
Professor James Shaw
Tetracycline-regulated secretion of human pro/insulin in transfected primary rat myoblasts2000
Professor James Shaw
Gene therapy for type II diabetes: will it have a role?1999
Professor James Shaw
Towards off the shelf gene therapy for diabetes: insulin expression in rats following intramuscular DNA injection1999