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Cellular senescence: Unravelling complexity

Lookup NU author(s): Dr Joao Passos, Dr Cedric Simillion, Dr Jennifer Hallinan, Professor Anil Wipat, Professor Thomas von Zglinicki

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Abstract

Cellular senescence might be a tumour suppressing mechanism as well as a contributor to age-related loss of tissue function. It has been characterised classically as the result of the loss of DNA sequences called telomeres at the end of chromosomes. However, recent studies have revealed that senescence is in fact an intricate process, involving the sequential activation of multiple cellular processes, which have proven necessary for the establishment and maintenance of the phenotype. Here, we review some of these processes, namely, the role of mitochondrial function and reactive oxygen species, senescence-associated secreted proteins and chromatin remodelling. Finally, we illustrate the use of systems biology to address the mechanistic, functional and biochemical complexity of senescence. © 2009 American Aging Association, Media, PA, USA.


Publication metadata

Author(s): Passos J, Simillion C, Hallinan J, Wipat A, Von Zglinicki T

Publication type: Review

Publication status: Published

Journal: Age

Year: 2009

Volume: 31

Issue: 4

Pages: 353-363

ISSN (print): 0161-9152

ISSN (electronic): 1574-4647

URL: http://dx.doi.org/10.1007/s11357-009-9108-11007

DOI: 10.1007/s11357-009-9108-1


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