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Browsing publications by Dr Joao Passos.

Newcastle AuthorsTitleYearFull text
Emily Dookun
Dr Joao Passos
Professor Helen Arthur
Dr Gavin Richardson
Therapeutic Potential of Senolytics in Cardiovascular Disease2022
Dr Arianna Bianchi
Letizia Marchetti
Hannah Paish
Dr Kile Green
Dr Dina Tiniakos
et al.
Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis2021
Edward Fielder
Dr Clare Tweedy
Dr Caroline Wilson
Professor Fiona Oakley
Dr Fiona LeBeau
et al.
Anti-inflammatory treatment rescues memory deficits during aging in nfkb1−/− mice2020
Emily Dookun
Dr Anna Walaszczyk
Dr Rachael Redgrave
Dr Pawel Palmowski
Dr Simon Tual-Chalot
et al.
Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery2020
Dr Axel Kowald
Dr Joao Passos
Emeritus Professor Thomas Kirkwood
On the evolution of cellular senescence2020
Stella Victorelli
Dr Joao Passos
Telomeres: beacons of autocrine and paracrine DNA damage during skin aging2020
Edward Fielder
Melanie Weigand
Dr Diana Jurk
Dr Joao Passos
Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk2020
Dr Diana Jurk
Dr Joao Passos
Professor Thomas von Zglinicki
Cellular Senescence: Defining a Path Forward2019
Dr Mikolaj Ogrodnik
Hanna Salmonowicz
Dr Diana Jurk
Dr Joao Passos
Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence2019
Rhys Anderson
Anthony Lagnado
Damien Maggiorani
Dr Anna Walaszczyk
Emily Dookun
et al.
Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence2019
Leena Habiballa
Hanna Salmonowicz
Dr Joao Passos
Mitochondria and cellular senescence: Implications for musculoskeletal ageing2019
Dr James Chapman
Edward Fielder
Dr Joao Passos
Mitochondrial dysfunction and cell senescence: deciphering a complex relationship2019
Emily Dookun
Dr Anna Walaszczyk
Dr Rachael Redgrave
Dr Simon Tual-Chalot
Oliver Yausep
et al.
Navitoclax eliminates senescence attenuating remodelling and improving outcome to cardiac ischemia-reperfusion injury2019
Dr Mikolaj Ogrodnik
Patrick Kruger
Edward Fielder
Stella Victorelli
Rifqha Ruswhandi
et al.
Obesity-Induced Cellular Senescence Drives Anxiety And Impairs Neurogenesis2019
Dr Anna Walaszczyk
Emily Dookun
Dr Rachael Redgrave
Dr Simon Tual-Chalot
Professor Ioakim Spyridopoulos
et al.
Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction.2019
Clara Correia Melo
Dr Jodie Birch
Edward Fielder
Dr James Chapman
Dr Anthony Lagnado
et al.
Rapamycin improves healthspan but not inflammaging in nfkb1-/- mice2019
Stella Victorelli
Dr Joao Passos
Reactive Oxygen Species Detection in Senescent Cells2019
Dr Joao Passos
Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition2019
Stella Victorelli
Dr Anthony Lagnado
Jessica Halim
Dr James Chapman
Dr Jodie Birch
et al.
Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction2019
Oliver Yausep
Emily Dookun
Dr Anna Walaszczyk
Dr Rachael Redgrave
Dr Simon Tual-Chalot
et al.
The Effects of Senolytics on Murine Cardiac Function and Morphology Post-Ischemia Reperfusion Injury2019
Dr Jodie Birch
Dr Joao Passos
The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype2019
Dr Diana Jurk
Dr Joao Passos
A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline2018
Emily Dookun
Dr Anna Walaszczyk
Dr Rachael Redgrave
Dr Simon Tual-Chalot
Oliver Yausep
et al.
Accumulation of cardiomyocyte senescence following ischaemia-reperfusion injury (IRI); a potential therapeutic target?2018
Emily Dookun
Dr Anna Walaszczyk
Dr Rachael Redgrave
Dr Simon Tual-Chalot
Oliver Yausep
et al.
Cardiomyocyte Senescence accumulates following Myocardial Infarction and Ischaemia-Reperfusion Injury.2018
Rhys Anderson
Dr Gavin Richardson
Dr Joao Passos
Mechanisms driving the ageing heart2018
Dr Jodie Birch
Dr Joao Passos
Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease2018
Dr James Chapman
Dr Joao Passos
Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis2018
Damien Maggiorani
Dr Joao Passos
Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy2018
Dr Bernadette Carroll
Diego Manni
Dr Rhoda Stefanatos
Fiona Menzies
Dr Graham Smith
et al.
Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis2018
Dr Anna Walaszczyk
Emily Dookun
Dr Rachael Redgrave
Dr Simon Tual-Chalot
Rhys Anderson
et al.
Senescence as a therapeutic target for myocardial ageing2018
Dr Anna Walaszczyk
Emily Dookun
Dr Rachael Redgrave
Professor Ioakim Spyridopoulos
Professor Helen Arthur
et al.
Senescence contributes age related cardiac dysfunction2018
Dr Anna Walaszczyk
Emily Dookun
Dr Rachael Redgrave
Professor Ioakim Spyridopoulos
Professor Helen Arthur
et al.
Senescence contributes to reduced survival and impaired cardiac function following myocardial infraction in aged mice.2018
Dr Joao Passos
Stress, cell senescence and organismal ageing2018
Damien Maggiorani
Dr Gavin Richardson
Dr Joao Passos
Young vs Old mouse cardiomyocytes RNA-Seq.2018
Dr Mikolaj Ogrodnik
Dr Satomi Miwa
Dr Dina Tiniakos
Dr Caroline Wilson
Professor Chris Day
et al.
Cellular senescence drives age-dependent hepatic steatosis2017
Dr Jodie Birch
Dr Joao Passos
Cellular senescence mediates fibrotic pulmonary disease2017
Dr Clara Correia Melo
Dr Joao Passos
Depletion of mitochondria in mammalian cells through enforced mitophagy2017
Hanna Salmonowicz
Dr Joao Passos
Detecting senescence: a new method for an old pigment2017
Dr Jodie Birch
Dr Joao Passos
Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?2017
Stella Victorelli
Dr Joao Passos
Telomeres and Cell Senescence - Size Matters Not2017
Dr Bernadette Carroll
Gisela Otten
Matthew Ratcliff
Dr Graham Smith
Dr Joao Passos
et al.
Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity2016
Dr Irina Neganova
Dr Evgeniya Shmeleva
Dr Jennifer Munkley
Dr Valeria Chichagova
Dr George Anyfantis
et al.
JNK/SAPK signalling is essential for efficient reprogramming of human fibroblasts to induced pluripotent stem cells2016
Dr Clara Correia Melo
Francisco Marques
Rhys Anderson
Dr Graeme Hewitt
Dr Bernadette Carroll
et al.
Mitochondria are required for pro-ageing features of the senescent phenotype2016
Dr Clara Correia Melo
Dr Jodie Birch
Dr Joao Passos
Powering senescence: The ugly side of mitochondria2016
Dr Graeme Hewitt
Dr Bernadette Carroll
Dr Clara Correia Melo
Mikolaj Ogrodnik
Dr Glyn Nelson
et al.
SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair2016
Dr Jodie Birch
Stella Victorelli
Rhys Anderson
Kasim Jiwa
Dr Elizabeth Moisey
et al.
Telomere Dysfunction and Senescence-associated Pathways in Bronchiectasis2016
Professor Bob Anderson
Dr Simon Tual-Chalot
Dr Rachael Redgrave
Rebecca Dodds
Dr Andrew Owens
et al.
The role of cardiomyocyte senescence and regeneration in Ageing2016
Dr Jodie Birch
Rhys Anderson
Clara Correia Melo
Dr Diana Jurk
Dr Graeme Hewitt
et al.
DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease2015
Dr Clara Correia Melo
Dr Joao Passos
Mitochondria: Are they causal players in cellular senescence?2015
Dr Caroline Wilson
Dr Diana Jurk
Nicola Fullard
Paul Banks
Dr Agata Page
et al.
NFkB1 is a suppressor of neutrophil-driven hepatocellular carcinoma2015
Dr Irina Neganova
Dr Katarzyna Tilgner
Dr Adriana Buskin
Iliana Paraskevopoulou
Dr Stuart Atkinson
et al.
CDK1 plays an important role in the maintenance of pluripotency and genomic stability in human pluripotent stem cells2014
Dr Diana Jurk
Dr Caroline Wilson
Dr Joao Passos
Professor Fiona Oakley
Clara Correia Melo
et al.
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice2014
Dr Graeme Hewitt
Professor Thomas von Zglinicki
Dr Joao Passos
Cell sorting of young and senescent cells2013
Dr Viktor Korolchuk
Dr Joao Passos
Lysosome-mediated processing of chromatin in senescence2013
Jen Birch
Dr Gavin Johnson
Professor Christopher Ward
Dr John Taylor
Emeritus Professor Nick Europe-Finner
et al.
Small Airway Epithelial Cell Senescence Present in COPD and Bronchiectasis?2013
Dr Conor Lawless
Dr Diana Jurk
Dr Colin Gillespie
Dr Daryl Shanley
Dr Gabriele Saretzki
et al.
A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations2012
Dr Joao Passos
Professor Thomas von Zglinicki
Mitochondrial dysfunction and cell senescence - skin deep into mammalian aging2012
Dr Graeme Hewitt
Dr Diana Jurk
Francisco Marques
Clara Correia Melo
Dr Timothy Hardy
et al.
Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence2012
Dr Irina Neganova
Dr Stuart Atkinson
Dr Joao Passos
Professor Thomas von Zglinicki
Professor Lyle Armstrong
et al.
An Important Role for CDK2 in G1 to S Checkpoint Activation and DNA Damage Response in Human Embryonic Stem Cells2011
Dr Joao Passos
Dr Glyn Nelson
Dr Cedric Simillion
Dr Carole Proctor
Dr Satomi Miwa
et al.
Feedback between p21 and reactive oxygen production is necessary for cell senescence2010
Dr Conor Lawless
Dr Diana Jurk
Alina Merz
Professor Thomas von Zglinicki
Dr Joao Passos
et al.
Quantitative assessment of markers for cell senescence2010
Dr Joao Passos
Dr Cedric Simillion
Dr Jennifer Hallinan
Professor Anil Wipat
Professor Thomas von Zglinicki
et al.
Cellular senescence: Unravelling complexity2009
Dr Shaheda Ahmed
Dr Joao Passos
Matthew Birket
Professor Thomas von Zglinicki
Telomerase protects mitochondria and lowers oxidative stress2009
Matthew Birket
Dr Joao Passos
Professor Thomas von Zglinicki
Professor Mark Birch-Machin
The Relationship between the Aging- and Photo-Dependent T414G Mitochondrial DNA Mutation with Cellular Senescence and Reactive Oxygen Species Production in Cultured Skin Fibroblasts2009
Dr Gabriele Saretzki
Theresia Walter
Dr Joao Passos
Dr Rebecca Stewart
Dr Simon Hoare
et al.
Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells2008
Matthew Birket
Dr Joao Passos
Professor Thomas von Zglinicki
Professor Mark Birch-Machin
Investigation of the relationship between the ageing- and photodependent T414G mitochondrial DNA mutation with cellular senescence and reactive oxygen species production in cultured skin fibroblasts2008
Dr Joao Passos
Dr Sharon Olijslagers
Professor Thomas von Zglinicki
Mitochondrial dysfunction is a possible cause of accelerated senescence of mesothelial cells exposed to high glucose2008
Dr Joao Passos
Portugal gets ready to embrace ageing research2008
Dr Joao Passos
Professor Thomas von Zglinicki
Retrograde response, oxidative stress and cellular senescence2008
Dr Joao Passos
Role of respiration and glutathione in cadmium-induced oxidative stress in Escherichia coli K-122008
Avgi Tsolou
Dr Joao Passos
Dr Glyn Nelson
Dr Yasumichi Arai
Professor Thomas von Zglinicki
et al.
ssDNA fragments induce cell senescence by telomere uncapping2008
Dr Saeed Ahmed
Dr Joao Passos
Matthew Birket
Dr Heiko Peters
Professor Mark Birch-Machin
et al.
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress2008
Dr Joao Passos
Dr Glyn Nelson
Professor Thomas von Zglinicki
Telomeres, Senescence, Oxidative stress and heterogeneity2008
Dr Joao Passos
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
DNA damage in telomeres and mitochondria during cellular senescence: Is there a connection?2007
Dr Joao Passos
Professor Thomas von Zglinicki
Methods for cell sorting of young and senescent cells2007
Dr Joao Passos
Professor Thomas von Zglinicki
Emeritus Professor Thomas Kirkwood
Mitochondria and ageing: Winning and losing in the numbers game2007
Professor Thomas von Zglinicki
Dr Joao Passos
Dr Gabriele Saretzki
Mitochondria and telomeres: Strange bedfellows in cell senescence2007
Dr Joao Passos
Dr Gabriele Saretzki
Dr Saeed Ahmed
Dr Glyn Nelson
Torsten Richter
et al.
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence2007
Dr Hamid Reza Soleimanpour Lichaei
Dr Joao Passos
Dr Mateusz Wydro
Dr Joanna Rorbach
Dr Richard Temperley
et al.
mtRF1a Is a Human Mitochondrial Translation Release Factor Decoding the Major Termination Codons UAA and UAG2007
Dr Joao Passos
Dr Glyn Nelson
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Oxygen free radicals in senescence: Are they signal transducers?2007
Dr Joao Passos
Dr Sharon Olijslagers
Dr Gabriele Saretzki
Dr Carmen Martin-Ruiz
Professor Thomas von Zglinicki
et al.
Premature senescence of mesothelial cells is associated with non-telomeric DNA damage2007
Dr Carmen Martin-Ruiz
Dr Joao Passos
Professor Thomas von Zglinicki
Extended lifespan and long telomeres in rectal fibroblasts from late-onset ulcerative colitis patients2006
Dr Joao Passos
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Mechanisms and role of oxidative damage to telomeres2006
Dr Joao Passos
Dr Gabriele Saretzki
Professor Thomas von Zglinicki
Mechanisms and role of oxidative damage to telomeres2006
Dr Joao Passos
Professor Thomas von Zglinicki
Dr Gabriele Saretzki
Mitochondrial dysfunction and cell senescence: Cause or consequence?2006
Dr Joao Passos
Professor Thomas von Zglinicki
Oxygen free radicals in cell senescence: Are they signal transducers?2006
Dr Joao Passos
Professor Thomas von Zglinicki
Mitochondria, telomeres and cell senescence2005
Dr Joao Passos
Strain PM2, a novel methylotrophic fluorescent Pseudomonas sp2003