Toggle Main Menu Toggle Search

Open Access padlockePrints

Increased maternal Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) associated with older age at diagnosis of Type 1 diabetes in offspring

Lookup NU author(s): Dr Nicola Leech, Dr John O'Sullivan, Dr Peter Avery, Laura Pascoe, Professor Mark Walker, Professor Timothy Cheetham


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


P>Aims Obesity and insulin resistance have been linked to rising incidence and earlier onset of Type 1 diabetes. Inherited differences in insulin action might also influence the evolution of Type 1 diabetes. Our aim was to determine whether parental BMI and insulin resistance influences age of onset of Type 1 diabetes in their offspring. Methods BMI standard deviation score and age at diagnosis of Type 1 diabetes was examined in 227 children, and in 206 of these was compared with local matched control subjects. Non-diabetic parents of a subgroup of 80 children with Type 1 diabetes were recruited. Parental BMI was compared with local adult control subjects. The relationship between parental BMI, waist-hip ratio, homeostasis model assessment of insulin resistance (HOMA-IR), leptin and adiponectin levels and age at diagnosis of Type 1 diabetes in offspring was examined. Results We found no relationship between age at diagnosis of Type 1 diabetes in children and BMI standard deviation score (P = 0.5). Children with Type 1 diabetes and their parents were heavier than matched control subjects (mean BMI standard deviation score +/- sd in children = 0.66 +/- 1.06 vs. 0.32 +/- 1.16 in control subjects, P = 0.002; mean parental BMI +/- sd 27.7 +/- 0.4 vs. 25.5 +/- 0.4 kg/m2 in control subjects; P < 0.0001). Maternal HOMA-IR accounted for 20% of variation in age at diagnosis (P < 0.001) with increasing maternal insulin resistance associated with later age at diagnosis of Type 1 diabetes. Conclusions Children with Type 1 diabetes and their parents have an increased BMI at diagnosis. Maternal insulin resistance is associated with later onset of Type 1 diabetes in children.

Publication metadata

Author(s): Leech NJ, O'Sullivan J, Avery P, Howey C, Burling K, Iyer S, Pascoe L, Walker M, Cheetham T

Publication type: Article

Publication status: Published

Journal: Diabetic Medicine

Year: 2010

Volume: 27

Issue: 12

Pages: 1450-1453

Print publication date: 09/11/2010

ISSN (print): 0742-3071

ISSN (electronic): 1464-5491

Publisher: Wiley-Blackwell


DOI: 10.1111/j.1464-5491.2010.03130.x


Altmetrics provided by Altmetric