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Lookup NU author(s): Professor Julie Irving,
Professor James Allan
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A role for specific HLA variants in the etiology of childhood acute lymphoblastic leukemia (ALL) has been extensively studied over the last 30 years, but no unambiguous association has been identified. To comprehensively study the relationship between genetic variation within the 4.5Mb MHC genomic region and precursor B-cell (BCP) ALL risk we analyzed 1,075 observed and 8,176 imputed SNPs and their related haplotypes in 824 BCP-ALL cases and 4,737 controls. Using these genotypes we also imputed both common and rare alleles at class I (HLA-A, HLA-B, and HLA-C) and class II (HLA-DRB1, HLA-DQA1, and HLA-DQB1) HLA loci. Overall we found no statistically significant association between variants and BCP-ALL risk. We conclude that MHC-defined variation in immune-mediated response is unlikely to be a major risk factor for BCP-ALL.
Author(s): Hosking FJ, Leslie S, Dilthey A, Moutsianas L, Wang Y, Dobbins SE, Papaemmanuil E, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Taylor M, Greaves M, McVean G, Houlston RS
Publication type: Article
Publication status: Published
Print publication date: 08/11/2010
ISSN (print): 0006-4971
ISSN (electronic): 1528-0020
Publisher: American Society of Hematology
PubMed id: 21059899
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