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MHC variation and risk of childhood B-cell precursor acute lymphoblastic leukaemia

Lookup NU author(s): Professor Julie Irving, Professor James Allan

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Abstract

A role for specific HLA variants in the etiology of childhood acute lymphoblastic leukemia (ALL) has been extensively studied over the last 30 years, but no unambiguous association has been identified. To comprehensively study the relationship between genetic variation within the 4.5Mb MHC genomic region and precursor B-cell (BCP) ALL risk we analyzed 1,075 observed and 8,176 imputed SNPs and their related haplotypes in 824 BCP-ALL cases and 4,737 controls. Using these genotypes we also imputed both common and rare alleles at class I (HLA-A, HLA-B, and HLA-C) and class II (HLA-DRB1, HLA-DQA1, and HLA-DQB1) HLA loci. Overall we found no statistically significant association between variants and BCP-ALL risk. We conclude that MHC-defined variation in immune-mediated response is unlikely to be a major risk factor for BCP-ALL.

Publication metadata

Author(s): Hosking FJ, Leslie S, Dilthey A, Moutsianas L, Wang Y, Dobbins SE, Papaemmanuil E, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Taylor M, Greaves M, McVean G, Houlston RS

Publication type: Article

Publication status: Published

Journal: Blood

Year: 2010

Volume: 117

Issue: 5

Pages: 1633-1640

Print publication date: 08/11/2010

ISSN (print): 0006-4971

ISSN (electronic): 1528-0020

Publisher: American Society of Hematology

URL: http://dx.doi.org/10.1182/blood-2010-08-301598

DOI: 10.1182/blood-2010-08-301598

PubMed id: 21059899

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