Toggle Main Menu Toggle Search

Open Access padlockePrints

Secretion of cytokines by villous cytotrophoblast and extravillous trophoblast in the first trimester of human pregnancy

Lookup NU author(s): Dr Katsuhiko Naruse, Barbara Innes, Dr Judith Bulmer, Professor Stephen Robson, Dr Roger Searle, Dr Gendie Lash

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Cytokines are proposed to play roles in regulation of trophoblast invasion, spiral artery remodeling and immunoregulation during early pregnancy. Secretion of 12 cytokines (interleukin (IL)-1 beta, IL-2,IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, IFN gamma, GM-CSF, MCP-1 and RANTES) by first trimester extravillous trophoblast and villous cytotrophoblast cells was examined using multiplex cytokine array technology. Seven (IL-1 beta, IL-8, IL-12p70, IL-13, GM-CSF, MCP-1 and RANTES) of the 12 cytokines examined were detectable in the samples studied (n = 10 each group). Villous cytotrophoblast production of IL-1 beta and IL-8 increased with gestational age. Extravillous trophoblast production of IL-8, IL-13 and RANTES increased with gestational age. At 12-14 weeks gestation extravillous trophoblast cells secreted higher levels of IL-8, IL-13 and RANTES than villous cytotrophoblast cells. (C) 2010 Elsevier Ireland Ltd. All rights reserved.


Publication metadata

Author(s): Naruse K, Innes BA, Bulmer JN, Robson SC, Searle RF, Lash GE

Publication type: Article

Publication status: Published

Journal: Journal of Reproductive Immunology

Year: 2010

Volume: 86

Issue: 2

Pages: 148-150

Print publication date: 17/06/2010

ISSN (print): 0165-0378

ISSN (electronic): 1872-7603

Publisher: Elsevier Ireland Ltd

URL: http://dx.doi.org/10.1016/j.jri.2010.04.004

DOI: 10.1016/j.jri.2010.04.004


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share