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Secretion of cytokines by villous cytotrophoblast and extravillous trophoblast in the first trimester of human pregnancy

Lookup NU author(s): Dr Katsuhiko Naruse, Barbara Innes, Dr Judith Bulmer, Professor Steve RobsonORCiD, Dr Roger Searle, Dr Gendie Lash


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Cytokines are proposed to play roles in regulation of trophoblast invasion, spiral artery remodeling and immunoregulation during early pregnancy. Secretion of 12 cytokines (interleukin (IL)-1 beta, IL-2,IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, IFN gamma, GM-CSF, MCP-1 and RANTES) by first trimester extravillous trophoblast and villous cytotrophoblast cells was examined using multiplex cytokine array technology. Seven (IL-1 beta, IL-8, IL-12p70, IL-13, GM-CSF, MCP-1 and RANTES) of the 12 cytokines examined were detectable in the samples studied (n = 10 each group). Villous cytotrophoblast production of IL-1 beta and IL-8 increased with gestational age. Extravillous trophoblast production of IL-8, IL-13 and RANTES increased with gestational age. At 12-14 weeks gestation extravillous trophoblast cells secreted higher levels of IL-8, IL-13 and RANTES than villous cytotrophoblast cells. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Naruse K, Innes BA, Bulmer JN, Robson SC, Searle RF, Lash GE

Publication type: Article

Publication status: Published

Journal: Journal of Reproductive Immunology

Year: 2010

Volume: 86

Issue: 2

Pages: 148-150

Print publication date: 17/06/2010

ISSN (print): 0165-0378

ISSN (electronic): 1872-7603

Publisher: Elsevier Ireland Ltd


DOI: 10.1016/j.jri.2010.04.004


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