Lookup NU author(s): Dr Katsuhiko Naruse,
Dr Judith Bulmer,
Professor Stephen Robson,
Dr Roger Searle,
Dr Gendie Lash
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Cytokines are proposed to play roles in regulation of trophoblast invasion, spiral artery remodeling and immunoregulation during early pregnancy. Secretion of 12 cytokines (interleukin (IL)-1 beta, IL-2,IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, IFN gamma, GM-CSF, MCP-1 and RANTES) by first trimester extravillous trophoblast and villous cytotrophoblast cells was examined using multiplex cytokine array technology. Seven (IL-1 beta, IL-8, IL-12p70, IL-13, GM-CSF, MCP-1 and RANTES) of the 12 cytokines examined were detectable in the samples studied (n = 10 each group). Villous cytotrophoblast production of IL-1 beta and IL-8 increased with gestational age. Extravillous trophoblast production of IL-8, IL-13 and RANTES increased with gestational age. At 12-14 weeks gestation extravillous trophoblast cells secreted higher levels of IL-8, IL-13 and RANTES than villous cytotrophoblast cells. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
Author(s): Naruse K, Innes BA, Bulmer JN, Robson SC, Searle RF, Lash GE
Publication type: Article
Publication status: Published
Journal: Journal of Reproductive Immunology
Print publication date: 17/06/2010
ISSN (print): 0165-0378
ISSN (electronic): 1872-7603
Publisher: Elsevier Ireland Ltd
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