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Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial

Lookup NU author(s): Dr Andrew Harbottle, Professor Mark Birch-MachinORCiD

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Abstract

P>Background Previous epidemiological, animal and human data report that lycopene has a protective effect against ultraviolet radiation (UVR)-induced erythema. Objectives We examined whether tomato paste - rich in lycopene, a powerful antioxidant - can protect human skin against UVR-induced effects partially mediated by oxidative stress, i.e. erythema, matrix changes and mitochondrial DNA (mtDNA) damage. Methods In a randomized controlled study, 20 healthy women (median age 33 years, range 21-47; phototype I/II) ingested 55 g tomato paste (16 mg lycopene) in olive oil, or olive oil alone, daily for 12 weeks. Pre- and postsupplementation, UVR erythemal sensitivity was assessed visually as the minimal erythema dose (MED) and quantified with a reflectance instrument. Biopsies were taken from unexposed and UVR-exposed (3 x MED 24 h earlier) buttock skin pre- and postsupplementation, and analysed immunohistochemically for procollagen (pC) I, fibrillin-1 and matrix metalloproteinase (MMP)-1, and by quantitative polymerase chain reaction for mtDNA 3895-bp deletion. Results Mean +/- SD erythemal D-30 was significantly higher following tomato paste vs. control (baseline, 26 center dot 5 +/- 7 center dot 5 mJ cm-2; control, 23 +/- 6 center dot 6 mJ cm-2; tomato paste, 36 center dot 6 +/- 14 center dot 7 mJ cm-2; P = 0 center dot 03), while the MED was not significantly different between groups (baseline, 35 center dot 1 +/- 9 center dot 9 mJ cm-2; control, 32 center dot 6 +/- 9 center dot 6 mJ cm-2; tomato paste, 42 center dot 2 +/- 11 center dot 3 mJ cm-2). Presupplementation, UVR induced an increase in MMP-1 (P = 0 center dot 01) and a reduction in fibrillin-1 (P = 0 center dot 03). Postsupplementation, UVR-induced MMP-1 was reduced in the tomato paste vs. control group (P = 0 center dot 04), while the UVR-induced reduction in fibrillin-1 was similarly abrogated in both groups, and an increase in pCI deposition was seen following tomato paste (P = 0 center dot 05). mtDNA 3895-bp deletion following 3 x MED UVR was significantly reduced postsupplementation with tomato paste (P = 0 center dot 01). Conclusions Tomato paste containing lycopene provides protection against acute and potentially longer-term aspects of photodamage.

Publication metadata

Author(s): Rizwan M, Rodriguez-Blanco I, Harbottle A, Birch-Machin MA, Watson REB, Rhodes LE

Publication type: Article

Publication status: Published

Journal: British Journal of Dermatology

Year: 2011

Volume: 164

Issue: 1

Pages: 154-162

Print publication date: 29/11/2010

ISSN (print): 0007-0963

ISSN (electronic): 1365-2133

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1365-2133.2010.10057.x

DOI: 10.1111/j.1365-2133.2010.10057.x

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