Publications by Professor Mark Birch-Machin - ePrints

Browsing publications by Professor Mark Birch-Machin.

Newcastle Authors	Title	Year
Professor Mark Birch-Machin Jessica Moor	Mitochondria as a Skin Health Biomarker	2024
Professor Mark Birch-Machin	Skin Life Analytics: A pro-ageing skin test for Aesthetic Clinics	2024
Wil Reynolds Dr Ndubuisi Eje Professor Paul Christensen Professor Mark Birch-Machin	Biological effects of air pollution on the function of human skin equivalents	2023
Jessica Moor Professor Mark Birch-Machin	Bioenergy and stressed out skin; what can we do?	2022
Professor Mark Birch-Machin	Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging	2022
Wil Reynolds Dr Amy Bowman Dr Peter Hanson Professor Mark Birch-Machin	Adaptive responses to air pollution in human dermal fibroblasts and their potential roles in ageing	2021
Dr Eyman Rashdan Dr Khimara Naidoo Professor Mark Birch-Machin	Distinctive clinical and histological characteristics of atrophic and hypertrophic facial photoageing	2021
Becky Zhu Dr Sophie Cassidy Dr Hugo Hiden Professor Mike Trenell Professor Mike Catt et al.	Exploration of sleep as a specific risk factor for poor metabolic and mental health: a UK Biobank study of 84,404 participants	2021
Rach Dixon Dr Wing Man Lau Dr Philip Manning Professor Mark Birch-Machin Professor Moein Moghimi et al.	Microneedle-based devices for point-of-care infectious disease diagnostics	2021
Dr Amy Bowman Professor Mark Birch-Machin	Mitochondrial DNA as a sensitive biomarker of UV-Induced Cellular Damage in Human Skin	2021
Professor Mark Birch-Machin	The Inhibition of Metabolic Inflammation by EPA is Associated with Enhanced Mitochondrial Fusion and Insulin Signalling in Human Primary Myotubes	2021
Wil Reynolds Dr Peter Hanson Professor Mark Birch-Machin	Exposing human primary dermal fibroblasts to particulate matter induces changes associated with skin aging	2020
Laura Hudson Dr Eyman Rashdan Catherine Bonn David Rawlings Professor Mark Birch-Machin et al.	Individual and combined effects of the infrared, visible and ultraviolet light components of solar radiation on damage biomarkers in human skin cells	2020
Dr Amy Bowman Dr Glyn Nelson Professor Mark Birch-Machin	Metabolic dysfunction in human skin: Restoration of mitochondrial integrity and metabolic output by nicotinamide (niacinamide) in primary dermal fibroblasts from older aged donors	2020
Roisin Stout Professor Mark Birch-Machin	Mitochondria's role in skin ageing	2019
Becky Zhu Professor Mike Catt Dr Sophie Cassidy Professor Mark Birch-Machin Professor Mike Trenell et al.	Objective sleep assessment in >80,000 UK mid-life adults: associations with sociodemographic characteristics, physical activity and caffeine	2019
Rebecca Hanna David Moore Professor Mark Birch-Machin	Optimised detection of mitochondrial DNA strand breaks	2019
Professor Mark Birch-Machin	The Mitochondria and Complex II- Linchpin for skin ageing and photoaging	2019
Dr Tom Clifford Dr Amy Bowman Tess Capper Dr Dean Allerton Dr Emma Foster et al.	A pilot study investigating reactive oxygen species production in capillary blood after a marathon and the influence of an antioxidant-rich beetroot juice.	2018
Nik Zakaria Dr Edward Okello Professor Mark Birch-Machin Dr Amy Bowman	In vitro protective effects of an aqueous extract of Clitoria ternatea L. flower against hydrogen peroxide-induced cytotoxicity and UV-induced mtDNA damage in human keratinocytes	2018
Dr Amy Bowman Professor Mark Birch-Machin	Nicotinamide enhances mitochondrial function in human skin cells	2018
Catherine Bonn Dr Khimara Naidoo Professor Mark Birch-Machin	Sunlight,diet and pollution- effects on oxidative stress and skin ageing	2018
Professor Mark Birch-Machin Dr Ellen Hatch	Tiron is Protective Against ROS-Induced Damage in Human Bronchial Epithelial Cells	2018
Professor Mark Birch-Machin	UVA-induced Carbon-Centered Radicals in Lightly Pigmented Cells detected using ESR Spectroscopy	2018
Dr Khimara Naidoo Rebecca Hanna Professor Mark Birch-Machin	What is the role of mitochondrial dysfunction in skin photoaging?	2018
Dr Angela Rodrigues Professor Falko Sniehotta Professor Mark Birch-Machin Professor Vera Araujo-Soares	Aware, motivated and striving for a ‘safe tan’: an exploratory mixed-method study of sun-protection during holidays	2017
Laura Hudson Dr Khimara Naidoo Dr Simon Wilkinson Professor Mark Birch-Machin	Bad air gets under your skin	2017
Dr Khimara Naidoo Professor Mark Birch-Machin	Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin	2017
Dr Angela Rodrigues Professor Falko Sniehotta Professor Mark Birch-Machin Professor Vera Araujo-Soares	Systematic and iterative development of a smartphone application to promote sun-protection amongst holidaymaker	2017
Dr Amy Bowman Professor Mark Birch-Machin	Age-dependent decrease of mitochondrial complex II activity in human skin fibroblasts	2016
Dr Amy Bowman Professor Mark Birch-Machin	Cosmetic sunscreen formulations provide protection against UVR-induced mitochondrial DNA damage in human skin cells	2016
Laura Hudson Dr Amy Bowman Dr Eyman Rashdan Professor Mark Birch-Machin	Mitochondrial damage and ageing using skin as a model organ	2016
Professor Mark Birch-Machin Dr Amy Bowman	Oxidative stress and ageing	2016
Dr Jennifer Latimer Dr James Lloyd Emeritus Professor Brian Diffey Professor Mark Birch-Machin	Determination of the action spectrum of UVR-induced mitochondrial DNA damage in human skin cells	2015
Dr SarahJayne Boulton Professor Mark Birch-Machin	Impact of hyperpigmentation on superoxide flux and melanoma cell metabolism at mitochondrial complex II.	2015
Dr Amy Bowman Professor Mark Birch-Machin	Mitochondrial DNA as a Biosensor of UV Exposure in Human Skin.	2015
Dr Anne Oyewole Professor Mark Birch-Machin	Mitochondrial-targeted antioxidants	2015
Dr Amy Bowman Professor Mark Birch-Machin	Oxidative stress - a key emerging impact factor in health, ageing, lifestyle and aesthetics	2015
Dr Anne Oyewole Professor Mark Birch-Machin	Sebum, Inflammasomes and the Skin: current concepts and future perspective	2015
Dr SarahJayne Boulton Dr Amy Bowman Roxanna Koohgoli Professor Mark Birch-Machin	Skin manifestations of mitochondrial dysfunction: more important than previously thought	2015
Dr Amy Bowman Professor Mark Birch-Machin Professor Georg Lietz	The Effect Of Nutritional Intervention On Blood Oxidative Stress Levels	2015
Dr SarahJayne Boulton Professor Mark Birch-Machin	The impact of hyperpigmentation on mitochondria: a comparative approach to investigating bioenergetic pathways in melanoma and keratinocyte cell types	2015
Alasdair Anderson Dr Amy Bowman Dr SarahJayne Boulton Dr Philip Manning Professor Mark Birch-Machin et al.	A role for human mitochondrial complex II in the production of reactive oxygen species in human skin	2014
Dr Angela Rodrigues Professor Falko Sniehotta Professor Mark Birch-Machin Professor Vera Araujo-Soares	Acceptability and feasibility of a mobile-phone intervention to promote sun safe behaviors amongst holidaymakers: findings from the internal pilot of the miskin randomized trial	2014
Dr Amy Bowman Dr Philip Manning Professor Mark Birch-Machin	Applicability of dermoscopy for evaluation of patients' response to nonablative therapies for the treatment of superficial basal cell carcinoma	2014
Dr Anne Oyewole Professor Mark Birch-Machin	Comparing the effects of mitochondrial targeted and localized antioxidants with cellular antioxidants in human skin cells exposed to UVA and hydrogen peroxide	2014
Professor Mark Birch-Machin	Effects of polyphenols on mitochondrial DNA damage in skin fibroblasts	2014
Dr SarahJayne Boulton Professor Mark Birch-Machin	Melanin reduces acute mitochondrial superoxide generation: a real-time amperometric study	2014
Dr Amy Bowman Professor Mark Birch-Machin	Responses to acute sun exposure in large whales	2014
Dr Amy Bowman Professor Mark Birch-Machin Dr SarahJayne Boulton	The roles of the mitochondrial respiratory chain complexes in UVA-induced oxidative stress in human skin cells compared to other cell types	2014
Dr Jennifer Latimer Professor Mark Birch-Machin	Using the Seahorse XF Analyser to evaluate real-time cellular respiration of human skin cells following the impact of oxidative stress inducers and the ability of idebenone and nicotinamide to mitigate these responses	2014
Dr Amy Bowman Professor Mark Birch-Machin	The simultaneous detection of mitochondrial DNA damage from sun-exposed skin of three whale species and its association with UV-induced microscopic lesions and apoptosis	2013
Professor Mark Birch-Machin Dr Robert Ellis Dr Jane Renwick Professor Penny Lovat	Increasing the therapeutic efficacy of docetaxel for cutaneous squamous cell carcinoma through the combined inhibition of phosphatidylinositol 3-kinase/AKT signalling and autophagy	2013
Professor Mark Birch-Machin Dr Jennifer Latimer	Mitochondrial DNA damage as a biomarker for ultraviolet radiation exposure and oxidative stress	2013
Dr Asif Tulah Professor Mark Birch-Machin	Stressed out mitochondria: The role of mitochondria in ageing and cancer focussing on strategies and opportunities in human skin	2013
Mohammed Asim Dr Edward Okello Professor Mark Birch-Machin Professor Georg Lietz	The anti-oxidant capacity of green tea polyphenols in the oral cavity	2013
Professor Mark Birch-Machin Dr Andrew Harbottle	The role of mitochondrial DNA damage in skin carcinogenesis and aging	2013
Dr Amy Bowman Professor Mark Birch-Machin	The simultaneous detection of mitochondrial DNA damage from sun-exposed skin of three whale species and its association with UV-induced microscopic lesions and apoptosis	2013
Professor Mark Birch-Machin Dr Amy Bowman	Whales Use Distinct Strategies to Counteract Solar Ultraviolet Radiation	2013
Dr Jennifer Latimer Dr Anne Oyewole Professor Mark Birch-Machin	Investigating the Protective Potential of the Antioxidant Tiron in Human Skin Cells Exposed to Ultraviolet Radiation	2012
Dr Helen Swalwell Dr Jennifer Latimer Professor Mark Birch-Machin	Investigating the role of melanin in UVA/B- and hydrogen peroxide-induced cellular and mitochondrial ROS production and mitochondrial DNA damage in human melanoma cells	2012
Dr Amy Bowman Professor Mark Birch-Machin	Mitochondrial DNA, a reliable biomarker for measuring the effect of cumulative ultraviolet irradiation exposure in whales (cetaceans)	2012
Dr Jennifer Latimer Professor Mark Birch-Machin	The Effects of Infrared Radiation versus Ultraviolet Radiation in Human Skin Cells	2012
Alasdair Anderson Dr SarahJayne Boulton Dr Helen Swalwell Dr James Henderson Dr Philip Manning et al.	Implications of using ROS sensitive probes in studies of UVA induced ROS in skin cells	2011
Dr SarahJayne Boulton Alasdair Anderson Dr Helen Swalwell Dr James Henderson Dr Philip Manning et al.	Implications of using the fluorescent probes, dihydrorhodamine 123 and 2 ',7 '-dichlorodihydrofluorescein diacetate, for the detection of UVA-induced reactive oxygen species	2011
Dr Christine Challen Professor Philip Sloan Professor Mark Birch-Machin Dr Max Robinson	Mitochondrial DNA mutations in head and neck cancer are infrequent and lack prognostic utility	2011
Dr Helen Swalwell Professor Mark Birch-Machin	Oxidative stress in human melanoma skin cells and its relationship with mitochondrial DNA damage and pigmentation	2011
Dr Helen Swalwell Dr SarahJayne Boulton Dr Philip Manning Emeritus Professor Calum McNeil Professor Mark Birch-Machin et al.	Real time electrochemical measurement of oxidative stress in human melanoma skin cells and its relationship with mitochondrial DNA damage and pigmentation	2011
Dr Helen Swalwell Professor Mark Birch-Machin	Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness	2011
Dr Jennifer Latimer Dr James Lloyd Professor Mark Birch-Machin	The action spectrum of UVR-induced damage within an 11 kb segment of mitochondrial DNA in human skin cells	2011
Dr Anne Oyewole Amy Bowman Theon Rogers Professor Mark Birch-Machin	The role, mechanism and protective effects of dietary antioxidants in human skin subjected to inducers of oxidative stress	2011
Dr Andrew Harbottle Professor Mark Birch-Machin	Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial	2011
Professor Mark Birch-Machin Dr Helen Swalwell	How mitochondria record the effects of UV exposure and oxidative stress using human skin as a model tissue	2010
Dr Helen Swalwell Dr Anne Oyewole Matthew Birket Professor Georg Lietz Professor Mark Birch-Machin et al.	Investigating the effects of mitochondrial-targeted antioxidants on mitochondrial function and DNA damage in human skin cells	2010
Dr Anne Oyewole Professor Mark Birch-Machin	Investigation of the protective effects of dietary antioxidants in human skin subjected to inducers of oxidative stress	2010
Dr Helen Swalwell Dr James Henderson Dr SarahJayne Boulton Dr Philip Manning Emeritus Professor Calum McNeil et al.	Oxidative stress in skin cells and its association with mitochondrial damage and skin cancer	2010
Alasdair Anderson Dr SarahJayne Boulton Dr Helen Swalwell Dr James Henderson Dr Philip Manning et al.	Potential pitfalls of measuring cellular oxidative stress using fluorescent probes, and the contribution of the individual mitochondrial respiratory chain complexes to oxidative stress generation in human skin	2010
Dr Andrew Harbottle Professor Mark Birch-Machin	Real-time polymerase chain reaction analysis of a 3895-bp mitochondrial DNA deletion in epithelial swabs and its use as a quantitative marker for sunlight exposure in human skin	2010
Shaun Martin Dr David Hill Professor Mark Birch-Machin Professor Penny Lovat Dr Chris Redfern et al.	Targeting GRP78 to enhance melanoma cell death	2010
Dr Emma Hiscutt Dr David Hill Shaun Martin Dr Andrew Harbottle Professor Mark Birch-Machin et al.	Targeting X-Linked Inhibitor of Apoptosis Protein to Increase the Efficacy of Endoplasmic Reticulum Stress-Induced Apoptosis for Melanoma Therapy	2010
Dr David Hill Shaun Martin Dr Jane Renwick Dr Ross Flockhart Dominic Simpson et al.	Combining the endoplasmic reticulum stress-inducing agents bortezomib and fenretinide as a novel therapeutic strategy for metastatic melanoma	2009
Dr James Henderson Dr Helen Swalwell Dr SarahJayne Boulton Dr Philip Manning Emeritus Professor Calum McNeil et al.	Direct, real-time monitoring of superoxide generation in isolated mitochondria	2009
Professor Penny Lovat Dr Jane Renwick Shaun Martin Dr David Hill Dr Chris Redfern et al.	Increasing Melanoma Cell Death Using Inhibitors of Protein Disulphide Isomerases to Abrogate Survival Responses to Endoplasmic Reticulum Stress	2009
Matthew Birket Dr Joao Passos Professor Thomas von Zglinicki Professor Mark Birch-Machin	The Relationship between the Aging- and Photo-Dependent T414G Mitochondrial DNA Mutation with Cellular Senescence and Reactive Oxygen Species Production in Cultured Skin Fibroblasts	2009
Dr Anne Oyewole Matthew Birket Diana Levett Dr Mark Anderson Dr Helen Swalwell et al.	The use of mitochondrial DNA to determine the role, mechanism and protective effects of antioxidants in human skin	2009
Professor Mark Birch-Machin Dr Anne Oyewole Alasdair Anderson Dr SarahJayne Boulton Dr Philip Manning et al.	The use of nanosensors and mitochondrial DNA to investigate oxidative stress and aging in human skin	2009
Alasdair Anderson Dr Gillian Aitken Dr Anne Oyewole Dr Helen Swalwell Jill Henderson et al.	To determine the relative roles of the different mitochondrial respiratory chain complexes in the production of oxidative stress in human skin	2009
Professor Mark Birch-Machin	Assessment of Mitochondrial Respiratory Complex Function In Vitro and In Vivo	2008
Dr David Hill Dr Jane Renwick Professor Mark Birch-Machin Professor Penny Lovat	B-RAF signalling in endoplasmic reticulum stress-induced apoptosis of metastatic melanoma	2008
Shaun Martin Dr David Hill Dr Jane Renwick Professor Mark Birch-Machin Dr Chris Redfern et al.	Combining endoplasmic reticulum stress-inducing agents with protein disulphide isomerase inhibition: a novel therapeutic strategy for metastatic melanoma	2008
Professor Penny Lovat Shaun Martin Dr Jane Renwick Dr Chris Redfern Professor Mark Birch-Machin et al.	Combining ER-stress-induced apoptosis with protein disulphide isomerase inhibition as a novel therapeutic strategy for metastatic melanoma	2008
Diana Levett Shaun Martin Professor Penny Lovat Professor Mark Birch-Machin	Endoplasmic reticulum stress-induced apoptosis in response to imiquimod: a novel therapeutic strategy for metastatic squamous cell carcinoma?	2008
Professor Penny Lovat Dr Jane Renwick Shaun Martin Dr David Hill Professor Mark Birch-Machin et al.	Increasing melanoma cell death using inhibitors of protein disulfide isomerases to abrogate survival responses to endoplasmic reticulum stress	2008
Matthew Birket Dr Joao Passos Professor Thomas von Zglinicki Professor Mark Birch-Machin	Investigation of the relationship between the ageing- and photodependent T414G mitochondrial DNA mutation with cellular senescence and reactive oxygen species production in cultured skin fibroblasts	2008
Dr Andrew Harbottle Professor Mark Birch-Machin	Lycopene protects against biomarkers of photodamage in human skin	2008
Professor Mark Birch-Machin	Skin photobiology	2008
Dr Saeed Ahmed Dr Joao Passos Matthew Birket Dr Heiko Peters Professor Mark Birch-Machin et al.	Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress	2008
Dr Andrew Harbottle Professor Mark Birch-Machin Dr Jameel Maki	The use of mitochondrial DNA as a "Biosensor" for UVR induced skin damage: Implications for personalized sun care and effective product formulation	2008
Professor Mark Birch-Machin	Clinical implications and utility of field cancerization	2007
Professor Penny Lovat Dr Chris Redfern Professor Mark Birch-Machin	Combining endoplasmic reticulum stress-inducing agents with protein disulphide isomerase inhibitors as a novel therapeutic strategy for metastatic melanoma	2007
Professor Penny Lovat Dr Chris Redfern Professor Mark Birch-Machin	Combining ER-stress inducing agents with protein disulphide inhibitors as a novel therapeutic strategy for metastatic melanoma	2007
Dr Andrew Harbottle Professor Mark Birch-Machin	Cutaneous photoprotection by dietary tomato product	2007
Dr David Hill Dr Jane Renwick Professor Mark Birch-Machin Professor Penny Lovat	Defining the role of B-RAF-induced extracellular signal-related kinase in the resistance of metastatic melanoma to apoptosis	2007
Dr Gillian Aitken Dr James Henderson Dr Seung Chang Emeritus Professor Calum McNeil Professor Mark Birch-Machin et al.	Direct monitoring of UV-induced free radical generation in HaCaT keratinocytes	2007
Professor Mark Birch-Machin	Management of field change in actinic keratosis	2007
Dr Joao Passos Dr Gabriele Saretzki Dr Saeed Ahmed Dr Glyn Nelson Torsten Richter et al.	Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence	2007
Professor Penny Lovat Dr Jane Renwick Dr David Hill Professor Mark Birch-Machin Dr Chris Redfern et al.	Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: The role of stress proteins ERdj5 and ERp57	2007
Matthew Birket Professor Mark Birch-Machin Dr Saeed Ahmed Dr Gabriele Saretzki	Telomerase-dependent protection of mitochondrial DNA in response to oxidative stress	2007
Professor Mark Birch-Machin	The mitochondrial genome: a biosensor for early cancer detection?	2007
Matthew Birket Professor Mark Birch-Machin	Ultraviolet radiation exposure accelerates the accumulation of the aging-dependent T414G mitochondrial DNA mutation in human skin	2007
Matthew Birket Professor Thomas von Zglinicki Professor Mark Birch-Machin	A photoageing-associated mitochondrial DNA mutation with potential functional consequences	2006
Professor Penny Lovat Dr Andrew Harbottle Dr Chris Redfern Professor Mark Birch-Machin	Fenretinide-induced apoptosis via endoplasmic reticulum stress - new drug targets for melanoma therapy?	2006
Professor Mark Birch-Machin	Mitochondrial DNA as a potential tool for early cancer detection	2006
Dr Andrew Harbottle Professor Mark Birch-Machin	Real-time PCR analysis of a 3895 bp mitochondrial DNA deletion in nonmelanoma skin cancer and its use as a quantitative marker for sunlight exposure in human skin	2006
Professor Mark Birch-Machin	Somatic mitochondrial DNA mutations in prostate cancer and normal appearing adjacent glands in comparison to age-matched prostate samples without malignant histology	2006
Professor Mark Birch-Machin	The dying melanocyte in the aging hair follicle displays oxidative stress damage: a model for tissue-specific aging	2006
Professor Mark Birch-Machin	The incidence of both tandem duplications and the common deletion in mtDNA from three distinct categories of sun-exposed human skin and in prolonged culture of fibroblasts	2006
Professor Mark Birch-Machin	The role of mitochondria in ageing and carcinogenesis	2006
Professor Mark Birch-Machin	Towards a "free radical theory of graying": Melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage	2006
Professor Nick Reynolds Dr Adrian Frank Lindi Skitt Emeritus Professor Doug Turnbull Professor Mark Birch-Machin et al.	Anthralin interacts with the Q pool and induces cytochrome c release, caspase 3 activation and apoptosis in human keratinocytes	2005
Dr James Henderson Dr Seung Chang Emeritus Professor Calum McNeil Professor Mark Birch-Machin	Direct real-time electrochemical measurement and flow cytometry of UVA induced oxidative stress and its perturbation by mitochondrial electron transport chain inhibitors	2005
Professor Nick Reynolds Dr Adrian Frank Lindi Skitt Emeritus Professor Doug Turnbull Professor Mark Birch-Machin et al.	Dithranol induces cytochrome c release, caspase 3 activation and apoptosis in human keratinocytes	2005
Emeritus Professor Doug Turnbull Professor Mark Birch-Machin Professor Nick Reynolds	The anti-psoriatic drug anthralin accumulates in keratinocyte mitochondria, dissipates mitochondrial membrane potential, and induces apoptosis through a pathway dependent on respiratory competent mitochondria	2005
Professor Mark Birch-Machin	Using mitochondrial DNA as a biosensor of early cancer development	2005
Dr Andrew Harbottle Professor Mark Birch-Machin	Implications of using the ND1 gene as a control region for real-time PCR analysis of mitochondrial DNA deletions in human skin [1]	2004
Professor Mark Birch-Machin Dr Andrew Harbottle	The incidence of a minor arc mitochondrial DNA deletion in human skin cancer and its novel use as a highly sensitive marker for sunlight exposure	2004
Kim Krishnan Dr Andrew Harbottle Professor Mark Birch-Machin	The use of a 3895 bp mitochondrial DNA deletion as a marker for sunlight exposure in human skin	2004
Professor Mark Birch-Machin	A maternal line study investigating the 4977-bp mitochondrial DNA deletion	2003
Professor Mark Birch-Machin	A maternal line study investigating the 4977-bp mitochondrial DNA deletion	2003
Dr Janet Lindsey Dr Meryl Lusher Professor Mark Birch-Machin	Current pitfalls in the measurement of the 4977 bp mitochondrial DNA common deletion in human skin	2003
Dr Meryl Lusher Professor Mark Birch-Machin	Direct generation of the mitochondrial DNA common deletion in cultured skin cells by repetitive ultraviolet irradiation	2003
Dr Adrian Frank Professor Mark Birch-Machin Professor Nick Reynolds	Mammalian cells deficient in respiratory competent mitochondria are resistant to dithranol	2003
Dr Steve Durham Professor Mark Birch-Machin	Mitochondrial DNA damage in non-melanoma skin cancer	2003
Dr Gillian Aitken Dr Andrew Harbottle Professor Mark Birch-Machin	The role of mitochondria in ultraviolet-induced oxidative stress	2003
Professor Mark Birch-Machin Emeritus Professor Doug Turnbull	Assaying mitochondrial respiratory complex activity in mitochondria isolated from human cells and tissues	2001
Dr Craig Dixon Dr Amanda Ray Sion Phillips William Cunliffe Dr Simon Meggitt et al.	Expression, candidate gene, and population studies of the melanocortin 5 receptor	2001
Dr Amanda Ray Carole Todd Professor Mark Birch-Machin Professor Jonathan Rees	The relation between melanocortin 1 receptor genotype and experimentally assessed ultraviolet radiation sensitivity	2001
Dr Eugene Healy Dr Amanda Ray Dr Niamh Flanagan Carole Todd Professor Mark Birch-Machin et al.	Evidence for variable selective pressures at MC1R	2000
Professor Mark Birch-Machin Professor Robert Taylor Emeritus Professor Doug Turnbull	Late-onset optic atrophy, ataxia, and myopathy associated with a mutation of a complex II gene	2000
Dr Eugene Healy Dr Amanda Ray Professor John Matthews Professor Mark Birch-Machin Professor Jonathan Rees et al.	Melanocortin-1-receptor gene and sun sensitivity in individuals without red hair	2000
Professor Mark Birch-Machin	Mitochondria and skin disease	2000
Dr Niamh Flanagan Dr Eugene Healy Dr Amanda Ray Carole Todd Professor Mark Birch-Machin et al.	Pleiotropic effects of the melanocortin 1 receptor (MC1R) gene on human pigmentation	2000
Dr Eugene Healy Professor Mark Birch-Machin Professor Jonathan Rees	The Human Melanocortin1-Receptor Gene	2000
Dr Amanda Ray Professor Jonathan Rees Professor Mark Birch-Machin	The spectrum of mitochondrial DNA deletions is a ubiquitous marker of ultraviolet radiation exposure in human skin	2000
Dr Eugene Healy Professor Mark Birch-Machin Professor Jonathan Rees	Distinct mutations in human basic hair keratins 1 and 6 cause monilethrix: Implications for protein structure and clinical phenotype	1999
Professor Jonathan Rees Professor Mark Birch-Machin Dr Niamh Flanagan Dr Eugene Healy	Genetic studies of the human melanocortin-1 receptor	1999
Professor Jonathan Rees Professor Mark Birch-Machin Dr Niamh Flanagan Dr Eugene Healy	Genetic studies of the human melanocortin-1 receptor	1999
Dr Niamh Flanagan Dr Eugene Healy Dr Amanda Ray Professor Mark Birch-Machin	Heterozygote mutants of the melanocortin 1 receptor show reduced tanning whilst homozyotes show red hair	1999
Dr Eugene Healy Professor Mark Birch-Machin Professor Jonathan Rees	Identification of novel mutations in basic hair keratins hHb1 and hHb6 in monilethrix: Implications for protein structure and clinical phenotype	1999
Professor Mark Birch-Machin Professor Jonathan Rees	Loss of function mutations of the human melanocortin 1 receptor are common and are associated with red hair.	1999
Dr Amanda Ray Dr Niamh Flanagan Professor Mark Birch-Machin Professor Jonathan Rees	Low frequency of genetic change in p53 immunopositive clones in human epidermis	1999
Dr Amanda Ray Dr Eugene Healy Carein Todd Dr Niamh Flanagan Professor Mark Birch-Machin et al.	Molecular genetic evidence for evolutionary selection of the red hair (MC1R) phenotype	1999
Dr Eugene Healy Professor Mark Birch-Machin Professor Jonathan Rees Catriona Munro	Point mutation in the helix termination peptide (HTP) of human type II hair keratin hHb6 causes monilethrix in five families	1999
Dr Eugene Healy Professor Mark Birch-Machin	Point mutations in the 1A domain (N114) of hair keratin hHb6 in monilethrix patients: A new hotspot for mutations?	1999
Professor Mark Birch-Machin	Riboflavine-response Leigh syndrome and leukodystrophy associated to partial succinate dehydrogenase deficiency	1999
Dr Eugene Healy Carole Todd Professor Mark Birch-Machin Professor Jonathan Rees	Skin type, melanoma, and melanocortin 1 receptor variants	1999
Professor Mark Birch-Machin Faye Haldane Professor Jonathan Rees	Mitochondrial DNA deletions in human skin reflect photo- rather than chronologic aging	1998