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False positive results in a neuroblastoma screening programme

Lookup NU author(s): Professor Louise Parker, Emeritus Professor Alan Craft, Mike Cole, James Smith


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Twenty thousand, eight hundred and twenty-nine babies were screened for neuroblastoma at 6 months of age by measuring homovanillic (HVA) and vanillylmandelic (VMA) acid in urine and ratioing these to creatinine. Using a ''cut off'' of the mean + 3 SD, 10 were found to be positive. Two were found on evaluation to have neuroblastoma and in the remaining 8 the raised levels of HVA and/or VMA returned to normal. Only one of the 8 false positive babies was absolutely normal, most having a chronic disorder or illness. Utilising new centiles which relate HVA and VMA to creatinine, only 3 of the 8 would have remained positive, a false positive rate of 0.01%. The false negative rate would have remained unchanged. (C) 1994 Wiley- Liss, Inc.

Publication metadata

Author(s): Bell S, Parker L, Craft AW, Dale G, McGill AC, Seviour J, Cole M, Smith J

Publication type: Article

Publication status: Published

Journal: Medical and Pediatric Oncology

Year: 1994

Volume: 22

Issue: 3

Pages: 181-186

ISSN (print): 0098-1532

ISSN (electronic): 1545-5017


DOI: 10.1002/mpo.2950220306

PubMed id: 8272007


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