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Lookup NU author(s): Professor Louise Parker,
Emeritus Professor Alan Craft,
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Twenty thousand, eight hundred and twenty-nine babies were screened for neuroblastoma at 6 months of age by measuring homovanillic (HVA) and vanillylmandelic (VMA) acid in urine and ratioing these to creatinine. Using a ''cut off'' of the mean + 3 SD, 10 were found to be positive. Two were found on evaluation to have neuroblastoma and in the remaining 8 the raised levels of HVA and/or VMA returned to normal. Only one of the 8 false positive babies was absolutely normal, most having a chronic disorder or illness. Utilising new centiles which relate HVA and VMA to creatinine, only 3 of the 8 would have remained positive, a false positive rate of 0.01%. The false negative rate would have remained unchanged. (C) 1994 Wiley- Liss, Inc.
Author(s): Bell S, Parker L, Craft AW, Dale G, McGill AC, Seviour J, Cole M, Smith J
Publication type: Article
Publication status: Published
Journal: Medical and Pediatric Oncology
ISSN (print): 0098-1532
ISSN (electronic): 1545-5017
PubMed id: 8272007
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