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The use of cultured bone marrow cells in autologous transplantation

Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci


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The feasibility of ex vivo purging with long-term bone marrow cultures (LTBMC) for autologous transplantation in leukemia has been established. The procedure has been applied to patients with acute myeloid leukemia (in relapse or remission) and recently in one patient with chronic myeloid leukemia. The results in first remission AML are very encouraging with 4 out of 6 patients well and apparently disease free greater than 1 to 4 years post autograft. In patients transplanted with active disease, remissions of 6 to 8 months duration were seen in two patients transplanted in florid relapse. In a CML patient with 87% of his bone marrow cells Ph1 positive, there was a marked decline of karyotypically abnormal cells in culture. Reinfusion of the cultured cells into the patient resulted in engraftment with exclusively Ph1 negative cells. The therapeutic implications of LTBMC purging require further evaluation.

Publication metadata

Author(s): Coutinho LH, Testa NG, Chang J, Morgenstern G, Harrison CJ, Dexter TM

Publication type: Article

Publication status: Published

Journal: Progress in Clinical and Biological Research

Year: 1990

Volume: 333

Pages: 415-432; discussion 433

ISSN (print): 0361-7742

Publisher: John Wiley & Sons, Inc.

Notes: Journal Article Research Support, Non-U.S. Gov't Review United states