ePrints

Genetic and environmental susceptibility to non-alcoholic fatty liver disease

Lookup NU author(s): Professor Chris Day

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

While the majority of those with non-alcoholic fatty liver disease (NAFLD) will have simple hepatic steatosis, a minority will develop progressive steatohepatitis. Family studies and inter-ethnic variations in susceptibility suggest that genetic factors may be important in determining disease risk. Although no genetic associations with advanced NAFLD have been replicated in large studies, preliminary data suggest that polymorphisms in genes controlling lipid metabolism, pro-inflammatory cytokines, fibrotic mediators and oxidative stress may be associated with steatohepatitis and/or fibrosis. Recent whole genome-wide scans have identified genes contributing to inherited susceptibility to steatosis and it seems likely that similar approaches will identify genes associated with disease progression in the near future. Copyright © 2010 S. Karger AG, Basel.

Publication metadata

Author(s): Day C

Publication type: Review

Publication status: Published

Journal: Digestive Diseases

Year: 2010

Volume: 28

Issue: 1

Pages: 255-260

Print publication date: 01/05/2010

ISSN (print): 0257-2753

ISSN (electronic): 1421-9875

URL: http://dx.doi.org/10.1159/000282098

DOI: 10.1159/000282098

PubMed id: 20460920

Share