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Allogeneic stem cell transplantation for rheumatic autoimmune diseases

Lookup NU author(s): Dr Thomas Huegle, Professor Jaap Van Laar


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Haematopoietic stem cell transplantation (HSCT) has evolved from an experimental concept to an effective treatment option for severe autoimmune diseases and has a unique ability to restore immune regulation. It is a complex multistep procedure involving the administration of high doses of immunosuppressive medication and transplantation of stem cells. Most HSCT procedures in autoimmune disease have involved autologous stem cells. In the case of allogeneic transplantation, stem cells are derived from peripheral blood or bone marrow of a healthy HLA-matched donor. Allogeneic HSCT has curative potential based on studies in experimental models of autoimmune disease, case reports, and a registry analysis but carries significant risks of rejection and graft-versushost disease. Unless these risks become manageable, allogeneic HSCT should be offered only if all alternative treatment options have failed, if a patient has a suitable donor, and if a patient still has a chance to benefit significantly from the procedure. © 2010 Medicine Reports Ltd.

Publication metadata

Author(s): Hügle T, Van Laar J

Publication type: Review

Publication status: Published

Journal: F1000 Medicine Reports

Year: 2010

Volume: 2

Issue: 1

Pages: 22

Print publication date: 25/03/2010

ISSN (print): 1757-5931

ISSN (electronic):


DOI: 10.3410/M2-22