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Philadelphia-positive metaphases in the marrow after bone marrow transplantation for chronic granulocytic leukemia

Lookup NU author(s): Professor Christine Harrison FRCPath FMedSci


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A 28-year-old man with Ph-positive chronic granulocytic leukemia (CGL) was treated by high-dose chemoradiotherapy and transplantation of marrow cells harvested from his HLA-identical brother. One year after bone marrow transplantation (BMT) examination of his marrow showed a minority population of Ph-positive cells; their proportion subsequently fell such that 2 years after transplant analysis of marrow cells showed only cytogenetically normal cells. The patient remains clinically normal with a persisting mild lymphocytosis but without hematological evidence of leukemia. We cannot in this patient distinguish between persisting leukemia that later could no longer be recognized and relapse of leukemia that is now suppressed, perhaps only temporarily. This case emphasizes the need for caution in interpreting chromosomal finding after BMT for CGL.

Publication metadata

Author(s): Apperley JF, Rassool F, Parreira A, Geary CG, Harrison CJ, Stansfield D, Goldman JM

Publication type: Article

Publication status: Published

Journal: American Journal of Hematology

Year: 1986

Volume: 22

Issue: 2

Pages: 199-204

ISSN (print): 0361-8609

ISSN (electronic): 1096-8652

Publisher: John Wiley & Sons, Inc.


DOI: 10.1002/ajh.2830220211

Notes: Case Reports Journal Article United states


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