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Lookup NU author(s): Dr Fiona Cuskin,
Dr Alexandra Solovyova,
Professor Rick Lewis,
Dr Paul Race
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The antibiotic bacillaene is biosynthesized in Bacillus subtilis by a hybrid type 1 modular polyketide synthase/nonribosomal peptide synthetase of the trans-acyltransferase (trans-AT) class. Within this system, the essential acyl-group loading activity is provided by the action of three free-standing trans-acting acyltransferases. Here, the recombinant expression, purification and crystallization of the bacillaene synthase trans-acting acyltransferase PksC are reported. A diffraction data set has been collected from a single PksC crystal to 1.44 A resolution and the crystal was found to belong to the orthorhombic space group P2(1)2(1)2(1).
Author(s): Cuskin F, Solovyova AS, Lewis RJ, Race PR
Publication type: Article
Publication status: Published
Journal: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online
Print publication date: 01/04/2011
ISSN (electronic): 1744-3091
Publisher: Wiley-Blackwell Publishing, Inc.
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