Toggle Main Menu Toggle Search

Open Access padlockePrints

Delta-sarcoglycan-deficient muscular dystrophy: from discovery to therapeutic approaches

Lookup NU author(s): Dr Alison Blain, Professor Volker StraubORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Mutations in the δ-sarcoglycan gene cause limb-girdle muscular dystrophy 2F (LGMD2F), an autosomal recessive disease that causes progressive weakness and wasting of the proximal limb muscles and often has cardiac involvement. Here we review the clinical implications of LGMD2F and discuss the current understanding of the putative mechanisms underlying its pathogenesis. Preclinical research has benefited enormously from various animal models of δ-sarcoglycan deficiency, which have helped researchers to explore therapeutic approaches for both muscular dystrophy and cardiomyopathy.

Publication metadata

Author(s): Blain AM, Straub VW

Publication type: Review

Publication status: Published

Journal: Skeletal Muscle

Year: 2011

Volume: 1

Issue: 1

Pages: 13

Print publication date: 17/03/2011

ISSN (electronic): 2044-5040


DOI: 10.1186/2044-5040-1-13