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Lookup NU author(s): Dr Colin Wilson,
Dr Nicholas Torpey,
Dr Lisa Turnbull,
Professor Derek Manas,
Professor Tim Goodship
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Atypical hemolytic uremic syndrome was diagnosed in a 62-year-old man. Sequencing of the CFH gene, which encodes complement factor H, revealed a heterozygous adenine to guanine mutation at nucleotide 3550 of the complementary DNA, leading to a predicted substitution of alanine for threonine at amino acid position 1184 in the protein (c.3550A>G, p.Thr1184Ala). Three years later, he received a simultaneous liver-kidney transplant with plasmapheresis and intratransplant plasma infusion. The postoperative course was complicated by an anastomotic biliary stricture that was treated successfully using endoscopic stenting. One year later, he has excellent function of both transplants, emphasizing that simultaneous liver-kidney transplant is a valuable treatment option in the management of adult patients with atypical hemolytic uremic syndrome. Am J Kidney Dis. 58(1):109-112. (C) 2011 by the National Kidney Foundation, Inc.
Author(s): Wilson C, Torpey N, Jaques B, Strain L, Talbot D, Manas D, Goodship T
Publication type: Article
Publication status: Published
Journal: American Journal of Kidney Diseases
Print publication date: 20/05/2011
ISSN (print): 0272-6386
ISSN (electronic): 1523-6838
Publisher: W.B. Saunders Co.
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