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Successful Simultaneous Liver-Kidney Transplant in an Adult With Atypical Hemolytic Uremic Syndrome Associated With a Mutation in Complement Factor H

Lookup NU author(s): Dr Colin Wilson, Dr Nicholas Torpey, Bryon Jaques, Dr Lisa Turnbull, David Talbot, Professor Derek Manas, Professor Tim Goodship


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Atypical hemolytic uremic syndrome was diagnosed in a 62-year-old man. Sequencing of the CFH gene, which encodes complement factor H, revealed a heterozygous adenine to guanine mutation at nucleotide 3550 of the complementary DNA, leading to a predicted substitution of alanine for threonine at amino acid position 1184 in the protein (c.3550A>G, p.Thr1184Ala). Three years later, he received a simultaneous liver-kidney transplant with plasmapheresis and intratransplant plasma infusion. The postoperative course was complicated by an anastomotic biliary stricture that was treated successfully using endoscopic stenting. One year later, he has excellent function of both transplants, emphasizing that simultaneous liver-kidney transplant is a valuable treatment option in the management of adult patients with atypical hemolytic uremic syndrome. Am J Kidney Dis. 58(1):109-112. (C) 2011 by the National Kidney Foundation, Inc.

Publication metadata

Author(s): Wilson C, Torpey N, Jaques B, Strain L, Talbot D, Manas D, Goodship T

Publication type: Article

Publication status: Published

Journal: American Journal of Kidney Diseases

Year: 2011

Volume: 58

Issue: 1

Pages: 109-112

Print publication date: 20/05/2011

ISSN (print): 0272-6386

ISSN (electronic): 1523-6838

Publisher: W.B. Saunders Co.


DOI: 10.1053/j.ajkd.2011.04.008


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Funder referenceFunder name
National Institute of Health Research of England
076113/C/04/ZWellcome Trust
G0701325UK Medical Research Council
WT061858Juvenile Diabetes Research Foundation