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HSP70-hom gene polymorphism as a risk factor of graft-versus-host disease

Lookup NU author(s): Dr Xiao Wang, Professor Anne Dickinson

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Abstract

Dimorphism with the heat shock protein-70 (HSP70-hom) gene was analysed in 232 donor-recipient pairs of haematopoctic stem cell transplants (HSCT) in relation to the incidence and severity of graft-versus-host disease (GvHD) and generation of graft-versus-host reactivity (GvHR) in an in vitro skin explant model. In addition to the previously reported associations of positive skin explant model. In addition to the previously reported associations of positive skin explant assay results and the recipient HSP70-hom (-2763) AA homozygous genotype with acute GvHD, the presence of the A allele in the recipient was found to be associated with positive GvHR while the donor A allele appreared as independent risk factor of chronic GvHD. HSP70-hom gene polymorphism associates with the development of post-transplant complications. Recipient and donor genotypes affect the risk of acute and chronic GvHD, respectively.


Publication metadata

Author(s): Kuzyk A, Bogunta-Kubik K, Jackson G, Cullin M, Wang XN, Dickinson A

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: 2nd European Congress of Immunology (ECI)

Year of Conference: 2009

Pages: 539-543

Publisher: Medimond SRL

Library holdings: Search Newcastle University Library for this item

ISBN: 9788875875237


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