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Prostaglandin therapy for ductal patency: how long is too long?

Lookup NU author(s): Dr Malcolm Brodlie


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The management of neonates born with duct-dependent congenital heart defects in association with prematurity or low birth weight is challenging. We describe two preterm and low birth weight infants with duct-dependent congenital heart disease where cardiac surgery was successfully delayed by maintaining ductal patency using a prolonged prostaglandin infusion. This allowed time for growth and maturation and therefore reduced the risks associated with surgery and cardiopulmonary bypass.Conclusion: Maintenance of ductal patency by a prolonged prostaglandin infusion in low birth weight or preterm infants with duct-dependent congenital heart disease is a viable option that allows cardiac surgery to be delayed whilst awaiting further growth and development.

Publication metadata

Author(s): Brodlie M, Chaudhari M, Hasan A

Publication type: Article

Publication status: Published

Journal: Acta Paediatrica, International Journal of Paediatrics

Year: 2008

Volume: 97

Issue: 9

Pages: 1303-1304

ISSN (print): 0803-5253

ISSN (electronic): 1651-2227

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/j.1651-2227.2008.00872.x


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