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Browsing publications by Dr Malcolm Brodlie.

Newcastle AuthorsTitleYearFull text
Dr Hannah Tumelty
Dr Geoff Shenton
Dr Malcolm Brodlie
Are trough tobramycin concentrations taken from a central venous catheter accurate enough to safely use?2022
Dr Joanne Martin
Dr Jen Townshend
Dr Malcolm Brodlie
Diagnosis and management of asthma in children2022
Dr Carlos Echevarria
Dr Simon Doe
Dr Malcolm Brodlie
Professor Christopher Ward
Dr Stephen Bourke
et al.
Elexacaftor-Tezacaftor-Ivacaftor improve Gastro-Oesophageal reflux and Sinonasal symptoms in advanced cystic fibrosis2022
Dr Nicola Hall
David Hamilton
Professor John Simpson
Steven Powell
Dr Malcolm Brodlie
et al.
Impact of COVID-19 on carers of children with tracheostomies2022
Kim Keltie
Dr Andrew Sims
Dr Malcolm Brodlie
Steven Powell
National Cohort Study of Health Care Resource Use after Pediatric Tracheostomy2022
Dr Iram Haq
Maryam Almulhem
Simone Soars
Dr Malcolm Brodlie
Precision Medicine Based on CFTR Genotype for People with Cystic Fibrosis2022
Dr Matthew Thomas
Dr Noreen Zainal Abidin
Dr Malcolm Brodlie
Treating nontuberculous mycobacteria in children with cystic fibrosis: a multicentre retrospective study2022
JinHeng Lin
Professor Michael Taggart
Dr Lee Borthwick
Professor Andrew Fisher
Dr Malcolm Brodlie
et al.
Acute cigarette smoke or extract exposure rapidly activates TRPA1-mediated calcium influx in primary human airway smooth muscle cells2021
Dr Michael Grayling
Dr Ben Shillitoe
Dr Malcolm Brodlie
Dr Louise Michaelis
Characterising the allergic profile of children with cystic fibrosis2021
Dr Iram Haq
Dr Mike Althaus
Dr Vinciane Saint-Criq
Dr Bernard Verdon
Dr Jen Townshend
et al.
Clinical and molecular characterisation of the R751L-CFTR mutation2021
Dr Iram Haq
Dr Malcolm Brodlie
Clinical characteristics of SARS-CoV-2 infection in children with cystic fibrosis: An international observational study2021
Catherine Hatton
Dr Rachel Botting
Dr Maria Duenas Fadic
Dr Iram Haq
Dr Bernard Verdon
et al.
Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-22021
Aaron Gardner
Dr Iram Haq
Dr Malcolm Brodlie
Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis2021
Dr Malcolm Brodlie
Successful biodegradable stent insertion in an infant with severe bronchomalacia and cystic fibrosis2021
Jason Powell
Dr Rachel Agbeko
Dr Malcolm Brodlie
Steven Powell
Tracheostomy trends in paediatric intensive care2021
Dr Noreen Zainal Abidin
Aaron Gardner
Dr Iram Haq
Dr Matthew Thomas
Dr Malcolm Brodlie
et al.
Trends in nontuberculous mycobacteria infection in children and young people with cystic fibrosis2021
Dr Malcolm Brodlie
Developing a core outcome set for children with protracted bacterial bronchitis2020
Dr Joy Allen
Dr Andrea Gonzalez-Ciscar
Dr Clare Lendrem
Dr Jana Suklan
Dr Louise Johnston
et al.
Diagnostic and economic evaluation of a point-of-care test for respiratory syncytial virus2020
Dr Corey Chan
Bruce Jaffray
Dr Malcolm Brodlie
Hany Gabra
Lung biopsy in children: when is it useful?2020
Dr Malcolm Brodlie
Neutrophils in community-acquired pneumonia: parallels in dysfunction at the extremes of age2020
Dr Jessica Roberts
Jason Powell
Dr Jake Begbie
Dr Gerard Siou
Andrew Welch
et al.
Pediatric tracheostomy: A large single-center experience2020
Dr Aaron Ions Gardner
Dr Iram Haq
Professor John Simpson
Dr Vinciane Saint-Criq
Dr Bernard Verdon
et al.
Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis2020
Dr Ugo Offor
Dr Christopher Bacon
Dr Jessica Roberts
Jason Powell
Dr Malcolm Brodlie
et al.
Transplantation For Congenital Heart Disease Is Associated With An Increased Risk Of Epstein-Barr Virus-Related Post-Transplant Lymphoproliferative Disorder In Children2020
Dr Aaron Ions Gardner
Dr Malcolm Brodlie
Dr Matthew Thomas
Epidemiology of Nontuberculous Mycobacteria Infection in Children and Young People with Cystic Fibrosis: Analysis of UK Cystic Fibrosis Registry2019
Dr Iram Haq
Dr Noreen Zainal Abidin
Attaybenes Socas Rodríguez
Dr Andrea Gonzalez-Ciscar
Dr Aaron Ions Gardner
et al.
Modulator therapies for cystic fibrosis2019
Dr Zheyi Liew
Dr Alan Fenton
Dr Sundeep Harigopal
Dr Saikiran Gopalakaje
Dr Malcolm Brodlie
et al.
Physiological effects of high-flow nasal cannula therapy in preterm infants2019
Dr Vinciane Saint-Criq
Dr Iram Haq
Dr Aaron Ions Gardner
Professor Christopher Ward
Dr Malcolm Brodlie
et al.
Real-Time, Semi-Automated Fluorescent Measurement of the Airway Surface Liquid pH of Primary Human Airway Epithelial Cells2019
Patrizia Calella
Dr Malcolm Brodlie
Professor Lorenzo Donini
Dr Mario Siervo
Tools and Methods Used for the Assessment of Body Composition in Patients With Cystic Fibrosis: A Systematic Review2019
Dr Jessica Roberts
Jason Powell
Dr Michael Mather
Steven Powell
Dr Malcolm Brodlie
et al.
A review of adenotonsillar hypertrophy and adenotonsillectomy in children after solid organ transplantation2018
Patrizia Calella
Dr Matthew Thomas
Dr Malcolm Brodlie
Dr Mario Siervo
Association between body composition and pulmonary function in children and young people with cystic fibrosis2018
Patrizia Calella
Dr Malcolm Brodlie
Professor Lorenzo Donini
Dr Mario Siervo
Cystic fibrosis, body composition, and health outcomes: a systematic review2018
Dr Tom Altmann
Dr James Slack
Dr Mary Slatter
Professor Andrew Cant
Dr Matthew Thomas
et al.
Endothelial cell damage in idiopathic pneumonia syndrome2018
Dr Adrien Tissot
Dr Matthew Thomas
Emeritus Professor Nick Europe-Finner
Dr Malcolm Brodlie
NonTuberculous Mycobacteria infection and lung transplantation in cystic fibrosis: A worldwide survey of clinical practice2018
Rhys Jones
Amaran Krishnan
Dr Malcolm Brodlie
Professor Jeffrey Pearson
Professor Stephen Bourke
et al.
Risk factors for lung disease progression in children with cystic fibrosis2018
Dr Aaron Ions Gardner
Dr Malcolm Brodlie
Role of Sphingolipids in Bacterial Infections2018
Dr Aaron Ions Gardner
Dr Malcolm Brodlie
Sphingolipids as targets for inhalation treatment of cystic fibrosis2018
Dr Noreen Zainal Abidin
Dr Iram Haq
Dr Aaron Ions Gardner
Dr Malcolm Brodlie
Ataluren in cystic fibrosis: development, clinical studies and where are we now?2017
Dr Malcolm Brodlie
Characterisation of eppin function: expression and activity in the lung2017
Salam Ibrahim
Mark Turner
Dr Vinciane Saint-Criq
Dr James Garnett
Dr Iram Haq
et al.
CK2 is a key regulator of SLC4A2- mediated Cl-/HCO3- exchange in human airway epithelia2017
Dr Matthew Thomas
Nicholas Robertson
Dr Nicola Miller
Professor Judith Rankin
Dr Michael McKean
et al.
Congenital lung agenesis: incidence and outcome in the North of England2017
Dr Malcolm Brodlie
How to use nasal nitric oxide in a child with suspected primary ciliary dyskinesia2017
Dr Hafez Al-momani
Rhys Jones
Professor Stephen Bourke
Dr Simon Doe
Dr John Perry
et al.
Nontuberculous mycobacteria in gastrostomy fed patients with cystic fibrosis2017
Dr Iram Haq
Dr Michael McKean
Dr Malcolm Brodlie
Should we use montelukast in wheezy children?2017
Dr Zheyi Liew
Professor Kate Gould
Dr Su Bunn
Dr Matthew Thomas
Dr James Lordan
et al.
Successful outcome following pneumonectomy in a teenage boy with cystic fibrosis: a case report.2017
Dr Aaron Ions Gardner
Professor Christopher Ward
Dr Malcolm Brodlie
β1-integrin accumulates in cystic fibrosis luminal airway epithelial membranes and decreases sphingosine promoting bacterial infections2017
Dr Iram Haq
Dr Aaron Ions Gardner
Dr Malcolm Brodlie
A multifunctional bispecific antibody against Pseudomonas aeruginosa as a potential therapeutic strategy2016
Dr Alison Robb
Dr Matthew Thomas
Dr Malcolm Brodlie
Dr Stephen Bourke
Dr John Perry
et al.
A novel culture medium for isolation of rapidly-growing mycobacteria from the sputum of patients with cystic fibrosis2016
Dr Iram Haq
Dr Michael Gray
Dr James Garnett
Professor Christopher Ward
Dr Malcolm Brodlie
et al.
Airway surface liquid homeostasis in cystic fibrosis: pathophysiology and therapeutic targets2016
Dr James Garnett
Dr Georgina Carr
Jason Powell
Dr Malcolm Brodlie
Professor Christopher Ward
et al.
Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion2016
Professor Christopher Ward
Emeritus Professor Nick Europe-Finner
Dr Malcolm Brodlie
IL-22 exacerbates weight loss in a murine model of chronic pulmonary Pseudomonas aeruginosa infection2016
Nicholas Robertson
Professor Judith Rankin
Dr Michael McKean
Dr Malcolm Brodlie
Dr Matthew Thomas
et al.
Incidence and outcome of congenital lung agenesis in the north of England2016
Gemma Zeybel
Professor Jeffrey Pearson
Amaran Krishnan
Dr Stephen Bourke
Dr Simon Doe
et al.
Ivacaftor and symptoms of extra-oesophageal reflux in patients with cystic fibrosis and G551D mutation2016
Dr Malcolm Brodlie
Dr Michael McKean
Leukotriene receptor antagonists as maintenance or intermittent treatment in pre-school children with episodic viral wheeze2016
Dr Hafez Al-momani
Dr Christopher Stewart
Rhys Jones
Amaran Krishnan
Dr Andrew Robertson
et al.
Microbiological profiles of sputum and gastric juice aspirates in Cystic Fibrosis patients2016
Emily Ward-Booth
Dr David Spencer
Professor Stephen Rushton
Dr Malcolm Brodlie
Dr Matthew Thomas
et al.
Predictors of primary treatment failure in children with empyema2016
Dr Alice Wort
Professor John Simpson
Dr David Spencer
Dr Matthew Thomas
Dr Malcolm Brodlie
et al.
Viruses associated with community-acquired pneumonia in children – a large prospective study in the post-prevenar 13 era2016
Dr James Garnett
Dr Michael Gray
Dr Malcolm Brodlie
Professor Christopher Ward
Airway epithelial cells secrete bicarbonate in response to acidic by-products of pseudomonas aeruginosa metabolism2015
Dr Malcolm Brodlie
Ali Aseeri
Dr James Lordan
Dr Andrew Robertson
Dr Michael McKean
et al.
Bile acid aspiration in people with cystic fibrosis before and after lung transplantation2015
Dr Alison Robb
Dr Malcolm Brodlie
Dr Stephen Bourke
Dr John Perry
Comparison of various culture media for the isolation of non-tuberculous mycobacteria from respiratory samples from patients with cystic fibrosis2015
Dr Malcolm Brodlie
Dr Michael McKean
Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children2015
Dr Malcolm Brodlie
Dr Iram Haq
Keith Roberts
Targeted therapies to improve CFTR function in cystic fibrosis2015
Dr Iram Haq
Dr Saikiran Gopalakaje
Dr Alan Fenton
Dr Michael McKean
Dr Malcolm Brodlie
et al.
The evidence for high flow nasal cannula devices in infants2014
Dr Shruti Parikh
Dr Andrew Robertson
Dr Malcolm Brodlie
Emeritus Professor Nick Europe-Finner
Professor Christopher Ward
et al.
Are the enzymatic methods currently being used to measure bronchoalveolar lavage bile salt levels fit for purpose?2013
Professor Michael Griffin
Dr Andrew Robertson
Dr Iain Brownlee
Rachel Stovold
Dr Malcolm Brodlie
et al.
Aspiration and Allograft Injury Secondary to Gastroesophageal Reflux Occur in the Immediate Post-Lung Transplantation Period (Prospective Clinical Trial)2013
Dr James Garnett
Dr Michael Gray
Dr Malcolm Brodlie
Professor Christopher Ward
Erin Baker
et al.
Elevated Paracellular Glucose Flux across Cystic Fibrosis Airway Epithelial Monolayers Is an Important Factor for Pseudomonas aeruginosa Growth2013
Amaran Krishnan
Dr Malcolm Brodlie
Emeritus Professor Nick Europe-Finner
Professor Michael Griffin
Dr Ian Forrest
et al.
Identical Biofilm Forming Strains of Pseudomonas aeruginosa Occur in Lung Allograft BAL and Gastric Juice from CF Patients with Gastro Oesophageal Reflux2013
Dr Malcolm Brodlie
Professor Christopher Ward
Emeritus Professor Nick Europe-Finner
Novel T helper cell responses against Pseudomonas aeruginosa in healthy individuals and patients with cystic fibrosis2013
Dr Michael McKean
Dr Malcolm Brodlie
Oesophageal foreign body presenting with stridor associated with feeding2013
Dr Saikiran Gopalakaje
Dr Alan Fenton
Dr Michael McKean
Dr Malcolm Brodlie
The evidence for high flow nasal cannula devices in infants2013
Dr Lee Borthwick
Emeritus Professor Nick Europe-Finner
Dr Rahul Mahida
Andrew Walker
Aaron Gardner
et al.
TNFα From Classically Activated Macrophages Accentuates Epithelial to Mesenchymal Transition in Obliterative Bronchiolitis2013
Ali Aseeri
Dr Malcolm Brodlie
Dr James Lordan
Emeritus Professor Nick Europe-Finner
Professor Jeffrey Pearson
et al.
Bile Acids Are Present in the Lower Airways of People with Cystic Fibrosis2012
Dr Malcolm Brodlie
Claire Graham
Dr Michael McKean
Childhood cough2012
Dr Malcolm Brodlie
Emeritus Professor Nick Europe-Finner
Dr James Lordan
Professor Christopher Ward
Interleukin-17 and Cystic Fibrosis Lung Disease2012
Dr Matt Bates
Dr Victoria Nesbitt
Dr Langping He
Dr Charlotte Alston
Dr Malcolm Brodlie
et al.
Mitochondrial respiratory chain disease in children undergoing cardiac transplantation: A prospective study2012
Dr Malcolm Brodlie
Dr David Spencer
Omalizumab for the Treatment of Paediatric Asthma2012
Dr Aaron Ions Gardner
Professor Andrew Fisher
Christine Richter
Grace Johnson
Dr Elizabeth Moisey
et al.
The Critical Role of TAK1 in Accentuated Epithelial to Mesenchymal Transition in Obliterative Bronchiolitis after Lung Transplantation2012
Dr Malcolm Brodlie
Dr Terence Flood
Dr David Spencer
The importance of thorough investigation of children with wet cough2012
Dr Malcolm Brodlie
Dr Michael McKean
Dr Samantha Moss
Dr David Spencer
The oral corticosteroid-sparing effect of omalizumab in children with severe asthma2012
Dr Malcolm Brodlie
Dr David Spencer
Use of somatostatin analogues to treat chylothorax in a child with Generalised Lymphatic Dysplasia2012
Dr Malcolm Brodlie
Dr Matthew Thomas
Dr David Spencer
Vitamin D in children with cystic fibrosis2012
Dr Lee Borthwick
Dr John Perry
Dr Malcolm Brodlie
Professor Christopher Ward
Katherine Gould
et al.
Pseudomonas aeruginosa accentuates epithelial-to-mesenchymal transition in the airway2011
Dr Malcolm Brodlie
Dr James Lordan
Professor Christopher Ward
Can cells other than Th17 lymphocytes be important sources of IL-17 in the lungs?2011
Dr Malcolm Brodlie
Dr James Lordan
Professor Christopher Ward
Ceramide and cystic fibrosis lung disease2011
Dr Malcolm Brodlie
Dr Michael McKean
Andrew Welch
Inflammatory myofibroblastic tumours of the respiratory tract: paediatric case series with varying clinical presentations2011
Dr Lee Borthwick
Phil Botha
Dr Malcolm Brodlie
Aaron Gardner
Dr David Bourn
et al.
Is CFTR-delF508 Really Absent from the Apical Membrane of the Airway Epithelium?2011
Dr Malcolm Brodlie
Dr Michael McKean
Dr Amy Anderson
Dr Catharien Hilkens
Professor Andrew Fisher
et al.
Raised interleukin-17 is immunolocalised to neutrophils in cystic fibrosis lung disease2011
Dr Malcolm Brodlie
Dr Michael McKean
Dr Joseph Gray
Professor Andrew Fisher
Emeritus Professor Nick Europe-Finner
et al.
Ceramide is Increased in the Lower Airway Epithelium of People with Advanced Cystic Fibrosis Lung Disease2010
Dr Malcolm Brodlie
Exhaled nitric oxide in the diagnosis of childhood asthma2010
Dr Lee Borthwick
Marta Gorowiec
Dr Malcolm Brodlie
Professor Christopher Ward
Dr James Lordan
et al.
Inflammation and Epithelial to Mesenchymal Transition in Lung Transplant Recipients: Role in Dysregulated Epithelial Wound Repair2010
Dr Malcolm Brodlie
Dr Michael McKean
Dr John Perry
Dr Burns Verdon
Dr Michael Gray
et al.
Primary bronchial epithelial cell culture from explanted cystic fibrosis lungs2010
Dr Lee Borthwick
Dr Malcolm Brodlie
Professor Christopher Ward
Dr John Perry
Emeritus Professor Nick Europe-Finner
et al.
The M1 macrophage phenotype accentuates TGF-beta 1 driven epithelial to mesenchymal transition (EMT) via the secretion of TNF alpha2010
Dr Aaron Ions Gardner
Dr Malcolm Brodlie
Professor Derek Mann
Dr Lee Borthwick
Professor Andrew Fisher
et al.
The role of transforming growth factor-beta activated kinase-1 (TAK-1) in the development of airway fibrosis2010
Dr Malcolm Brodlie
Dr Catharien Hilkens
Professor Christopher Ward
Airway epithelial cells as guardians of immune homeostasis?2009
Professor Christopher Ward
Julie Diboll
Professor Andrew Fisher
Dr Malcolm Brodlie
Dr James Lordan
et al.
Bronchial epithelial cells cultured from clinically stable lung allograft patients promote the development of macrophages from monocytes rather than dendritic cells2009
Dr Malcolm Brodlie
Dr David Spencer
Bronchomalacia occurring in monozygotic twins - Further information about its inheritance2009
Dr Malcolm Brodlie
Dr David Spencer
Bronchomalacia occurring in monozygotic twins - further information about its inheritance2009
Dr Malcolm Brodlie
Dr Michael McKean
Professor Andrew Fisher
Emeritus Professor Nick Europe-Finner
Dr James Lordan
et al.
Ceramide is increased and associated with neutrophilic inflammation in the lower airway epithelium of people with cystic fibrosis2009
Dr Malcolm Brodlie
Dr Michael McKean
Exhaled nitric oxide in the diagnosis of childhood asthma2009
Dr Malcolm Brodlie
Dr Terence Flood
Dr David Spencer
Heterogeneity in the clinical manifestations of mannose-binding lectin deficiency2009
Dr Malcolm Brodlie
Dr Terence Flood
Dr Fiona Black
Dr David Spencer
Lymphoid bronchiolitis presenting at birth in an immunocompetent child: Chronic interstitial lung disease of unknown aetiology2009
Dr Malcolm Brodlie
Dr Michael McKean
Picture quiz: Dyspnoea and cough in a toddler2009
Dr Lee Borthwick
Dr Malcolm Brodlie
Professor Christopher Ward
Dr James Lordan
Professor John Kirby
et al.
Pro-inflammatory Cytokines IL-1 beta and TNT alpha, but Not IL-8, Cause Aberrant Lung Epithelial Wound Repair Via TGF-beta 1 Driven Epithelial to Mesenchymal Transition (EMT)2009
Dr Malcolm Brodlie
Dr Michael McKean
Professor Andrew Fisher
Emeritus Professor Nick Europe-Finner
Dr James Lordan
et al.
Reticular basement membrane thickening in end-stage cystic fibrosis lung disease2009
Dr Malcolm Brodlie
Dr David Spencer
Growth recovery after withdrawal of inappropriate inhaled fluticasone proprionate2008
Dr Malcolm Brodlie
Dr Michelle Muller
Dr Leslie Mitchell
Dr David Spencer
High-resolution computed tomography in children with confirmed post-infectious obliterative bronchiolitis2008
Dr Malcolm Brodlie
Hypertrophic cardiomyopathy and transposition of great arteries associated with maternal diabetes and presumed gestational diabetes2008
Dr Malcolm Brodlie
Prostaglandin therapy for ductal patency: how long is too long?2008
Dr Malcolm Brodlie
Dr Michael McKean
Strategies to screen for adrenal suppression in children with asthma: there is no consensus among UK centres2008
Dr Malcolm Brodlie
Dr Michael McKean
Dr John Perry
Anne Nicholson
Professor Jeffrey Pearson
et al.
The culture of primary bronchial epithelial cells from the lungs of people with cystic fibrosis removed at the time of transplantation: a model to study cystic fibrosis lung disease2008
Dr Malcolm Brodlie
Compliance with inhaled corticosteroids is important when considering adrenal suppression2007
Dr Malcolm Brodlie
Dr Jonathan Wyllie
Interference of electrocardiographic recordings by a mobile telephone2007
Dr Malcolm Brodlie
Strategies to screen for adrenal suppression in children with asthma should take account of compliance with inhaled corticosteroids2007
Dr Christian Harkensee
Dr Malcolm Brodlie
Professor Nicholas Embleton
Dr Michael McKean
Passive immunisation of preterm infants with palivizumab against RSV infection2006
Dr Malcolm Brodlie
Ten years of neonatal autopsies in tertiary referral centre: retrospective study2002
Dr Malcolm Brodlie
Characterization of Strains of Mycoplasma mycoides subsp. mycoides Small Colony Type Isolated from Recent Outbreaks of Contagious Bovine Pleuropneumonia in Botswana and Tanzania: Evidence for a New Biotype.2000
Dr Malcolm Brodlie
Comparison of the virulence of European and African isolates of Mycoplasma mycoides subspecies mycoides small colony type2000