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Lookup NU author(s): Professor Olaf Heidenreich
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The NF-kappaB and NF-IL6 elements have previously been shown to play an important role in regulation of both the mouse and human interleukin-6 gene. Between these two elements lies a G/C-rich sequence, which contains three repeats of the element CCACC, protein binding to which has not been previously characterized. In this study we demonstrate that the transcription factor Sp1 binds to these repeats and plays an important role in basal and in inducible expression of the murine interleukin-6 gene.
Author(s): Kang SH, Brown DA, Kitajima I, Xu X, Heidenreich O, Gryaznov S, Nerenberg M
Publication type: Article
Publication status: Published
Journal: Journal of Biological Chemistry
Print publication date: 01/03/1996
ISSN (print): 0021-9258
ISSN (electronic): 1083-351X
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