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Binding and functional effects of transcriptional factor Sp1 on the murine interleukin-6 promotor

Lookup NU author(s): Professor Olaf Heidenreich

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Abstract

The NF-kappaB and NF-IL6 elements have previously been shown to play an important role in regulation of both the mouse and human interleukin-6 gene. Between these two elements lies a G/C-rich sequence, which contains three repeats of the element CCACC, protein binding to which has not been previously characterized. In this study we demonstrate that the transcription factor Sp1 binds to these repeats and plays an important role in basal and in inducible expression of the murine interleukin-6 gene.

Publication metadata

Author(s): Kang SH, Brown DA, Kitajima I, Xu X, Heidenreich O, Gryaznov S, Nerenberg M

Publication type: Article

Publication status: Published

Journal: Journal of Biological Chemistry

Year: 1996

Volume: 271

Issue: 13

Pages: 7330-7335

Print publication date: 01/03/1996

ISSN (print): 0021-9258

ISSN (electronic): 1083-351X

URL: http://dx.doi.org/10.1074/jbc.271.13.7330

DOI: 10.1074/jbc.271.13.7330

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