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Structure, function and evolution of multidomain proteins

Lookup NU author(s): Dr Matthew BashtonORCiD


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Proteins are composed of evolutionary units called domains; the majority of proteins consist of at least two domains. These domains and nature of their interactions determine the function of the protein. The roles that combinations of domains play in the formation of the protein repertoire have been found by analysis of domain assignments to genome sequences. Additional findings on the geometry of domains have been gained from examination of three-dimensional protein structures. Future work will require a domain-centric functional classification scheme and efforts to determine structures of domain combinations.

Publication metadata

Author(s): Vogel C, Bashton M, Kerrison ND, Chothia C, Teichmann SA

Publication type: Article

Publication status: Published

Journal: Current Opinion in Structural Biology

Year: 2004

Volume: 14

Issue: 2

Pages: 208-216

ISSN (print): 0959-440X

ISSN (electronic): 1879-033X

Publisher: Elsevier Ltd


DOI: 10.1016/

PubMed id: 15093836


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