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Antibody-mediated allograft rejection: The emerging role of endothelial cell signalling and transcription factors

Lookup NU author(s): Fatmah Naemi, Professor Simi Ali, Emeritus Professor John Kirby


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The presence of antibodies against class I human leukocyte antigens (HLA) can cause the development of chronic allograft rejection. Although endothelial cell activation has been identified as a main effector, the mechanisms mediating this process are not fully understood. Exposure of endothelium to antibodies against HLA antigens induces cell activation which promotes rejection. This activation process can be divided into two phases: an early response in which intracellular signalling proteins and transcription factors are activated, and a later change in protein expression and cell function. In this review, antibody-mediated endothelial signalling and the role of transcription factors in organ transplantation will be described with a particular focus on their potential to mediate some of the graft-damaging effects of anti-HLA class I antibodies. (C) 2011 Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Naemi FMA, Ali S, Kirby JA

Publication type: Article

Publication status: Published

Journal: Transplantation Immunology

Year: 2011

Volume: 25

Issue: 2-3

Pages: 96-103

Print publication date: 19/07/2011

ISSN (print): 0966-3274

ISSN (electronic): 1878-5492

Publisher: Elsevier BV


DOI: 10.1016/j.trim.2011.07.004


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