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Lookup NU author(s): Professor Miles Whittington,
Dr Anita Roopun
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Few common neurological illnesses trace back to single molecular disturbances. Many disparate putative causes may co-associate with a single disease state. However, uncovering functional, hierarchical networks of underlying mechanisms can provide a framework in which many primary pathologies converge on more complex, single higher level correlates of disease. This article focuses on cognitive deficits associated with schizophrenia to illustrate: a) How non-invasive EEG biomarkers of cognitive function constitute such a 'higher level correlate' of underlying pathologies. b) How derangement of multiple, cell-specific, molecular processes can converge on such EEG-visible, correlates of disrupted cognitive function. This approach suggests that evidence-based design of multitarget therapies may take advantage of hierarchical patterns of convergence to improve both efficacy and selectivity of disease-intervention.
Author(s): Whittington MA, Roopun AK, Traub RD, Davies CH
Publication type: Article
Publication status: Published
Journal: Current Opinion in Pharmacology
Print publication date: 07/05/2011
ISSN (print): 1471-4892
ISSN (electronic): 1471-4973
Publisher: Elsevier Ltd
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