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Lookup NU author(s): Professor Olaf Heidenreich
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Antisense oligonucleotides inhibit gene expression by binding in a sequence-specific manner to an RNA target. Modern nucleotide chemistry has enabled the synthesis of chemically modified oligonucleotides that are highly resistant to nuclease degradation. Among other applications, these agents are currently being evaluated as potential antiviral and anticancer drugs. However, several unsolved problems remain. Poor efficiency of delivery to cells, tissue toxicity and antisense-independent biological effects of oligonucleotides currently limit the widespread application of antisense oligonucleotides to human disease. This article reviews some of the applications of antisense oligonucleotides and discusses problems associated with these applications.
Author(s): Heidenreich O, Kang SH, Xu X, Nerenberg M
Publication type: Review
Publication status: Published
Journal: Molecular Medicine Today
ISSN (print): 1471-4914