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SAFB1 and SAFB2 mediated transcriptional repression: relevance in cancer

Lookup NU author(s): Elaine Hong, Dr Hannah Gautrey, Professor David Elliott, Professor Alison Tyson-Capper


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Scaffold attachment factor B1 (SAFB1) and a second family member, SAFB2 are multifunctional proteins implicated in a variety of cellular processes including cell growth, apoptosis and stress response. Their potential function as tumour suppressors have been put forward based on well-described roles in transcriptional repression. This review summarises the current knowledge of SAFB1 and SAFB2 in transcriptional repression with relevance to cancer.

Publication metadata

Author(s): Hong EA, Gautrey HL, Elliott DJ, Tyson-Capper AJ

Publication type: Review

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2012

Volume: 40

Issue: 4

Pages: 826-830

Print publication date: 01/08/2012

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752


DOI: 10.1042/BST20120030